Systems and methods for reducing pathogens near an implant are discussed. In some cases, the methods include reducing contaminants in a portion of a patient that has an implant and that is disposed interior to a closed surface of skin of the patient. The method can further include placing a conduit in the closed surface of skin and flowing an antimicrobial fluid into that portion of the patient to contact the antimicrobial fluid with a surface of the implant and tissue adjacent to the implant. In some cases, the antimicrobial fluid is then removed from the portion of the patient having the implant. As part of this method, biofilm near the implant can be mechanically, ultrasonically, electrically, chemically, enzymatically, or otherwise disrupted. Other implementations are described.

An infusion pump system is disclosed. The infusion pump system includes an infusion pump and a controller device in wireless communication with the infusion pump, wherein the controller including instructions for controlling the infusion pump, wherein the instructions may be synchronized with a secure web portal.

A system for warming intravenous fluids is provided including a positioning holder configured to receive and support a tube for providing at least one intravenous fluid to a patient and a plurality of elongate heating fingers, wherein each elongate heating finger is configured to be independently manipulated such that said elongate heating finger contacts the tube to transfer heat to the at least one intravenous fluid provided via the tube.

An at least partly implantable system for injecting a substance into a patient's body. The system comprises at least one flexibly bendable infusion needle with a tip end of each of said at least one infusion needle arranged in at least one first housing for penetrating the first housing's outer wall in at least one penetration area and having the respective other end arranged in at least one second housing, the first and second housings being adapted for implantation inside the patient's body, wherein the at least one second housing is provided for implantation inside the patient's body remote from the at least one first housing and wherein the injection needle is sufficiently long to bridge the distance from the at least one second housing for remote implantation to the at least one first housing and further through the first housing up to the outer wall of the first housing. The system further comprises at least one drive unit adapted for being coupled to the at least one infusion needle and arranged at least for advancing the tip end of the at least one infusion needle so that the at least one infusion needle penetrates with the tip end or ends thereof said at least one first housing's outer wall in said at least one penetration area.

The mouthpiece for an aerosol-generating article comprises a housing with an inlet end, configured to allow an aerosol to flow into the mouthpiece, an outlet end, configured to allow the aerosol to flow out of the mouthpiece, and an aerosol flow path extending between the inlet and the outlet end. The mouthpiece is formed such that the flow direction of the aerosol is reversed at least once between the inlet and the outlet end. The invention also concerns an aerosol-generating system comprising an aerosol-generating device and the mouthpiece, as well as a method for assembling the mouthpiece.

The invention is a cooling unit for a heat exchanger, which preferably is a heat exchanger integrated in an oxygenator for the purpose of controlling the temperature of blood conveyed in an extracorporeal blood circuit. The cooling unit has a reservoir in which a liquid is stored, a reaction vessel comprises a reactant and which, in conjunction with the liquid, is able to initiate an endothermal reaction. A fluidic access is generated between the reservoir and the reaction vessel. A fluid line extends at least in part inside the reaction vessel which has an inlet line and outlet line, which are each connectable or connected in a fluid-tight manner to a hose system of the heat exchanger, which together with the hose system of the heat exchanger, provides least part of a fluid circuit.

The invention relates to a microneedle array having a heat-generating element and its use for the intradermal application of active ingredients, particularly active pharmaceutical ingredients (API) and drugs, wherein this microneedle array is suitable for skin penetration on humans or animals and the microneedles consist of a water-soluble formulation, which contains at least one active ingredient.

A system for applying a lavage fluid to a surface, the system having a body configured to house a lavage fluid, an application member in fluid communication with the body, the application member being configured to dispense the lavage fluid, and a warming component configured to communicate with the body so as to transfer energy from the warming component to the body sufficient to warm the lavage fluid housed in the body.

There is provided in accordance with an exemplary embodiment of the invention, a device and a method for controlled extraction of at least one active substance from at least one type of plant matter by application of heat, the device comprising: a heating element adapted to apply heat to an area of the plant matter to extract the substance; and a mechanism adapted for moving the plant matter relative to the heating element. Optionally, the active substance is a restricted substance. There is also provided in accordance with an exemplary embodiment of the invention, a method of monitoring and controlling inhalation of a restricted substance. There is provided in accordance with an exemplary embodiment of the invention, a method of manufacturing a tape of plant matter comprising an active substance.

The present invention provides a thermo-controlled smell generating device with an active cooling mechanism to allow a user thereof to control on/off of the device in a relatively short response time absent any temperature fluctuations even after a significant number of heating and cooling cycles. The present invention is ideal for generating olfaction in highly interactive or fast-changing environments such as virtual immersive environments.