Systems and methods for reducing pathogens near an implant are discussed. In some cases, the methods include reducing contaminants in a portion of a patient that has an implant and that is disposed interior to a closed surface of skin of the patient. The method can further include placing a conduit in the closed surface of skin and flowing an antimicrobial fluid into that portion of the patient to contact the antimicrobial fluid with a surface of the implant and tissue adjacent to the implant. In some cases, the antimicrobial fluid is then removed from the portion of the patient having the implant. As part of this method, biofilm near the implant can be mechanically, ultrasonically, electrically, chemically, enzymatically, or otherwise disrupted. Other implementations are described.

The present invention relates to a method of replenishing a system for injecting a substance into the patient's body, when the system is implanted in the patient's body. The method involves replenishing the implanted reservoir by a replenishing needle penetrating the patient's skin and injecting infusion liquid comprising the substance through the replenishing needle directly or indirectly into the reservoir.

An apparatus and method for aspirating, irrigating and/or cleansing wounds is provided. The apparatus and method include one or more of the following: simultaneous aspiration and irrigation of the wound, supplying of thermal energy to fluid circulated through the wound; supplying physiologically active agents to the wound; a biodegradable scaffold in contact with the wound bed; and application of stress or flow stress to the wound bed.

A method of treating a patient by implanting a system comprising an infusion device for injecting a substance, at least one reservoir comprising at least one compartment which accommodates and preserves the substance to be injected, and an active cooling device adapted to cool the reservoir and thereby keep the substance within said at least one compartment of the reservoir at a temperature below 37 C. The method comprises the steps of: cutting the skin, dissecting free at least one area within the patient's body, placing the infusion device and the at least one reservoir inside the patient's body along with the cooling device, such that the at least one reservoir is in fluid connection with the infusion device to supply to the infusion device the substance to be injected into the patient's body, and closing at least the skin after implantation of at least parts of the system.

An auto-injector device comprises a stopper for expelling a medicament out of a medicament reservoir; a driving element which has a first configuration and a second configuration and is configured to change shape from the first configuration to the second configuration when the temperature of the driving element is raised above a shape change temperature, so as to drive the stopper of the syringe mechanism through the medicament reservoir; and a heating mechanism configured to actively heat the driving element. The heating mechanism is a chemical heating element configured to generate heat through an exothermic process or comprises a fluid reservoir for retaining a fluid; a heater configured to heat the fluid in the fluid reservoir; a pump configured to expel the fluid out of the fluid reservoir; and a connecting conduit arranged to carry the fluid from the fluid reservoir to the driving element.

A system includes a nasal cannula having a flexible tube configured to transmit oxygen gas to a user, an optical fiber coupled to the nasal cannula and configured to transmit light having a frequency spectrum range at least including that of light resulting from combustion of the nasal cannula while transmitting the oxygen gas to the user, a detector operatively coupled to the optical fiber and configured to detect the light transmitted through the optical fiber, and a valve. The valve is configured to be actuated to interrupt the transmission of the oxygen gas to the user through the nasal cannula in response to a signal from the detector.

A lip conditioning device for providing enhanced tissue therapy to lip tissue of a user, the device including a mouthpiece having a chamber with a distal end configured to create a seal with a portion of lip tissue of a user; a base portion, connected to the mouthpiece, including a controller in communication with a power source, and a suction device configured to remove air within the chamber; and a set of controls, in communication with the controller, configured to control a mode of operation of the tissue therapy.

The invention discloses a micro-negative pressure foam dressing and a manufacturing method thereof, the dressing comprises a exothermic agent layer, an isolation component covering on the exothermic agent layer, an elastic memory piece disposed under the exothermic agent layer, a liquid absorbing negative pressure pad disposed under the elastic memory piece, a contact layer disposed under the liquid absorbing negative pressure pad, a sealing film disposed between the liquid absorbing negative pressure pad and the contact layer, and a bottom release film disposed under the contact layer; and in this invention, heat generated by a exothermic agent layer causes an elastic memory piece to expand downward to compress a foam layer, and after the heat dissipates completely, a micro-negative pressure is generated since a sealed environment is formed by a sealing film, a contact layer and a wound surface without a need for the VSD negative pressure technology, which is simple to operate, simple in structure, low in cost, small in volume and portable.

The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

A device is provided that humidifies breathing gas. The device has a chamber with an inlet and an outlet. A chemical heater is positioned within the chamber and a trigger activates the heater. The chamber can be a conduit with an inner wall and an outer wall with a reservoir defined therebetween. The chemical heater can be positioned within the reservoir.