This system for in-body-cavity liquid perfusion of a circulating type which circulates a liquid such as an isotonic solution perfused within the body cavity, suppresses an excessive increase in internal pressure that would lead to breakage of a hollow fiber membrane module. A drain valve is connected to a drain port of the hollow fiber membrane module. A pressure sensor measures the internal pressure of the hollow fiber membrane module. A control unit opens the drain valve on the basis of the internal pressure of the hollow fiber membrane module measured by the pressure sensor, draining foreign matter from the hollow fiber membrane.

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized.

Various types of a medical device are described which is used as an implantable renal replacement therapy (an implantable artificial kidney). This device removes toxins and excess water from blood of patients with kidney failure or end stage renal disease. Additionally, other configurations of the device can be used as an external (extracorporeal) device.

A filter device includes a distal housing comprising a distal inner port and a distal outer port; a proximal housing comprising a proximal inner port and a proximal outer port, the proximal housing being sealingly affixed to the distal housing to form an inspiratory pathway between the distal inner port and the proximal inner port and to form an expiratory pathway between the distal outer port and the proximal outer port that is fluidly sealed from the inspiratory pathway, the inspiratory pathway being laterally adjacent the expiratory pathway; and a first filter in the inspiratory pathway or in the expiratory pathway to filter gases flowing through the inspiratory pathway or the expiratory pathway.

The invention relates to a method for venting a dialyzer which has a dialyzate chamber, a blood chamber and a semi-permeable dialyzer membrane separating these two chambers, wherein an overpressure is generated in the dialyzate chamber with respect to the blood chamber for removing air inclusions lying at the surface of the membrane at the dialyzate chamber side after a filling of the dialyzate chamber and before a filling of the blood chamber.

A method is presented for checking the integrity of a hollow-fibre fluid filter, in particular a hollow-fibre dialyzer (1), which is constructed from a plurality of hollow fibres (15) enclosed by a membrane, with the steps of: perfusing the inside or outside of the hollow fibres (15) with a fluid, supplying the outside or inside of the hollow fibres (15) with a gas, wherein the gas has a higher pressure than the fluid, and determining a quantity of the gas which penetrates into the fluid through holes in the membrane. The method is characterized in that, after flowing through the hollow-fibre fluid filter (1), the fluid is channelled through a bubble trap (30), and in that a volume of gas (41) collecting in the bubble trap (30) during a predefined or predefinable reference period is determined. Furthermore, equipment for checking the integrity of a hollow-fibre fluid filter (1) is presented.

Disclosed herein is a disposable set for operation with first and second concentrate containers in fluid communication with first and second concentrate container connectors. The disposable set includes a pumping cassette comprising at least a first concentrate port and a second concentrate port. The disposable cassette also includes a first concentrate line in fluid communication with the first concentrate port and a second concentrate line in fluid communication with the second concentrate port. The first concentrate line terminates at a first concentrate line connector having a first configuration for mating with the first concentrate container connector. The second concentrate line terminates at a second concentrate line connector having a second, different configuration for mating with the second concentrate container connector, such that the first concentrate line connector cannot mate with the second concentrate container connector and the second concentrate line connector cannot mate with the first concentrate container connector.

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized.

Provided herein are a control arrangement, a solution generation apparatus, and a method for evaluating an integrity of a forward osmosis (FO) membrane of a FO-device in a dialysis solution generation apparatus. The FO-device is configured to be used in a FO session for diluting a dialysis concentrate in a process for producing a dialysis solution. The FO-membrane separates a first side from a second side of a FO-device. The method comprises passing electrolyte solution at the first side and passing low-electrolyte solution at the second side. The method further comprises measuring conductivity of a solution generated from the second side and evaluating the integrity of the FO-membrane based on whether the measured conductivity meets conductivity criteria. The conductivity criteria include a conductivity of a solution generated from the second side with an equivalent electrolyte solution and an equivalent low-electrolyte solution using a FO-membrane that is intact or has integrity.

Provided herein are a control arrangement and a method for determining a water permeability status of a forward osmosis (FO) membrane of a FO device in a dialysis fluid generation apparatus. The FO-membrane separates a feed side and a draw side of the FO device. The FO-device comprises a feed inlet port and a feed outlet port in fluid communication with the feed side, and a draw inlet port and a draw outlet port in fluid communication with the draw side. The method comprises providing a flow of pure water at the feed side and providing a flow of pure water at the draw side. The method further comprises monitoring one or more pressures indicative of a transmembrane pressure between the feed side and the draw side.