An oxygen concentrator may have a compressor to feed a feed gas for sieve bed(s) via a first manifold, an accumulator to receive enriched air from the bed(s) via a second manifold. It may include an outer housing for the manifolds, the compressor, and the accumulator. The housing may include an access portal to a compartment therein, for removably receiving the bed(s) as a canister assembly. The first manifold may be adjacent to the compartment and have inlet coupling(s) for removably coupling respectively with inlet(s) of the canister assembly. The inlet coupling(s) may each have a first central axis. The second manifold may be adjacent to the compartment and have outlet coupling(s) for removably coupling respectively with outlet(s) of the canister assembly. The outlet coupling(s) may each having a second central axis. The first and second central axes may form any one of an obtuse, acute, or right angle.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.

Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on the injector device, or on a portion of the injection device housing, or on a drug reservoir. Some devices may be removably attached to a drug reservoir, for example, through a luer connector. Other devices may comprise internal luer seal for securely connecting a drug conduit of the device to the luer cavity of a drug reservoir. Yet other devices may comprise a priming-enabling element to facilitate the drug priming of a shielded needle. Related methods and systems comprising the devices are also described.

Embodiments of the present disclosure provide a method and apparatus for filtering and surgical procedures. An exemplary apparatus includes an evacuation tube having a filter, a long axis and a hollow conduit extending through the long axis, the hollow conduit fluidly connecting a tube inlet and a tube outlet, the filter located within the hollow conduit operable to remove particles from a flow passing through the hollow conduit from the tube inlet to the tube outlet.

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

The operational parameters of a respiratory apparatus can be controlled through the use of a user interface located on a separate or separable mobile computing device. Sensors or features located on the mobile computing apparatus can be used to adjust the operation parameters or therapy of the respiratory apparatus or otherwise improve the compliance of a patient utilizing the respiratory apparatus.

An oxygen concentrator (100) may have a moisture conditioning system. In some implementations, the concentrator includes a compressor to induce feed gas into the concentrator. A first pathway may receive the feed gas from the compression system. The first pathway may be configured to draw moisture to produce moisture reduced feed gas. The first pathway may lead the moisture reduced feed gas to sieve bed(s) which produce oxygen enriched air with the moisture reduced feed gas. An accumulator may be configured to receive the produced oxygen enriched air from the sieve bed(s). A second pathway from the accumulator may apply the drawn-out moisture to the produced enriched air to produce humidified enriched air. A third pathway may transfer the drawn-out moisture from the first pathway to the second pathway. An outlet coupled with the second pathway may release the humidified enriched air from the concentrator for a user.

Embodiments of a canister for a negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, the canister includes a receptacle for receiving wound exudate. A filter stack is interposed between the receptacle and the pump assembly and provides a fluid flow path therebetween. The flow path is more easily navigable by gas than by liquid, thereby allowing the pump assembly to apply a negative pressure to the canister without aspirating wound exudate into filters housed within the filter stack.

A patient interface including a seal-forming structure having a mouth portion that forms at least part of the mouth plenum and is configured to seal around the patient's mouth and a nasal portion that is configured to seal with the patient's nares. The nasal portion includes a nasal plenum positioned to receive pressurized gas from the mouth plenum. The seal-forming structure also includes a clip configured to connect the mouth plenum to the nasal plenum and act as a conduit for the flow of the pressurized gas from the mouth plenum to the nasal plenum. The clip includes a mouth portion end configured to engage the mouth portion, a nasal portion end configured to engage the nasal portion, and a pair of wings protruding from the nasal portion end into an interior of the nasal plenum so that the wings engage an interior surface of the nasal plenum.

A protective membrane for a medical luer connector may include a cover having an upper surface, a lower surface having a mating portion for coupling to a mating surface of the medical luer connector, and an outer perimetal surface. The protective membrane may further include a flexible pull tab extending from the outer perimetal surface of the cover, and an adhesive overlaying the mating portion of the lower surface for adhering to the mating surface of the medical luer connector.