Hydrophilic infusion tubes and infusion components are provided. A fluid pathway connects a first fluid port and a second fluid port, the fluid pathway formed of a base material suitable for fluid infusion and a hydrophilic fluid interfacing surface disposed on an inner surface of the fluid pathway. The hydrophilic fluid interfacing surface provides a water wetting contact angle that is less than a water wetting contact angle provided by the base material. Infusion sets are also provided.

The invention concerns a reservoir (1) for storing a liquid medicament. The reservoir (1) comprises a flexible container (10) which includes one folding layer (12), wherein the folding layer (12) includes a seam (13) which provides for a sealing of the flexible container (1). The reservoir comprises a rigid part (20) which is connected to the flexible container (10) and which includes a support (25) extending into the flexible container (10) and which includes one or more ports (21, 22) providing fluidic access to the flexible container (10). The reservoir comprises a porous hydrophilic membrane (26) which is connected to the support (25) of the rigid part (20). The invention further concerns a method for producing of a reservoir (1). The method comprises: providing a flexible tube (30) and a movable opening device (40) located inside the flexible tube (30), moving (S1) the moveable opening device (40) inside the flexible tube (30) by a distance in a longitudinal direction of the flexible tube (30), providing a rigid part (20), and bonding (S2) the flexible tube (30) to the rigid part (20) and providing a folding layer (12) included in the flexible container (10).

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

A hollow fiber membrane and methods of making the hollow fiber membrane are described. The membrane includes a hydrophobic polymer such as polysulfone, a hydrophilic polymer such as polyvinylpyrrolidone (PVP), and a fluropolymer additive, and optionally a stabilizer, for instance, to stabilize the fluoropolymer additive in the membrane, particularly during conditioning or E-beam sterilization or both. Further conditioning improvements to membrane manufacturing are disclosed. The membrane may be incorporated into a dialysis filter for use in hemodialysis and related applications. The membrane has improved hemocompatibility, charge stability, or middle molecule clearance compared to conventional membranes. Also disclosed is a method of evaluating membrane charge stability.

Systems, devices, and method for gas removal from a wearable device are provided. The systems comprise a gas removal filter having an inlet, a fluid outlet, and a vent port. The gas removal filter comprises a filter mesh between the inlet and outlet, the filter mesh configured to allow only liquid phase material through the filter mesh. The systems also comprises a gas detector for detecting gas in the gas removal filter; a orientation sensor for determining an orientation of the gas removal filter; a transducer protector filter having a first side and a second side, the transducer protector filter on fluid communication with the vent port of the gas removal filter; a pressure transducer in fluid communication with the second side of the transducer protector filter; and an gas removal pump in fluid communication with the second side of the transducer protector filter.

A system for applying a lavage fluid to a surface, the system having a body for housing a lavage fluid, an application member in fluid communication with the body, the application member being configured to dispense the lavage fluid along a flow path, and a venting component, the venting component having a fluid channel configured to provide fluid communication between the body and an external environment, and at least one filter provided relative to the fluid channel sufficient to filter gas, such as air, passing through the fluid channel, at least a portion of the fluid channel being separate from the flow path.

The present invention provides infusion devices, such as intravascular (IV) devices, comprising a hydrophilic sintered porous plastic filter or a hydrophilic porous fiber filter which are effective at stopping or greatly reducing transmission of air through the filter.

Systems, apparatuses, and methods for providing negative pressure to a tissue site are closed. Illustrative embodiments may include a system comprising a dressing having tissue interface in fluid communication with the tissue site. Such system may also comprise a canister having a fluid inlet fluidly coupled to the canister and an ambient inlet fluidly coupled to ambient air outside the collection chamber. Such system may further comprise a first outlet fluidly coupled to the canister and adapted to receive negative pressure from a source of negative pressure, and a second outlet. Such system also may comprise a fluid conductor fluidly coupled between the second outlet and the tissue interface, wherein the fluid conductor may be adapted to deliver ambient air to the tissue site. In some embodiments, such system may also comprise a regulator fluidly coupled between the second outlet and the ambient inlet, wherein the regulator is adapted to provide ambient air through the fluid conductor to the tissue site in a controlled fashion.

Provided herein are systems and methods for monitoring one or more health or physiological parameters in a subject. The systems and methods may comprise a patch coupled to an injector. Data may be transmitted to a mobile device or remote server, where the data may be processed. Processed data may be used to inform a subject on a health or physiological condition.

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.