Disclosed are hemodialysis and similar dialysis systems including fluid flow circuits. Hemodialysis systems may include a blood flow path, and a dialysate flow path including balancing, mixing, and/or a directing circuits. Preparation of dialysate may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit and/or the various fluid flow paths may be isolated from electrical components. A gas supply may be provided that, when activated, is able to urge dialysate through the dialyzer and blood back to the patient. Such a system may be useful during a power failure. The hemodialysis system may also include fluid handling devices, such as pumps, valves, mixers, etc., actuated using a control fluid. The control fluid may be delivered to the fluid handling devices using a detachable external pump. The fluid handling devices may have a spheroid shape with a diaphragm dividing it into two compartments.

A vaccination device can be used to vaccinate day-old chicks. To vaccinate the day-old chicks safely while ensuring vaccination efficacy, the vaccination device can include a vaccination needle configured to extend from the vaccination device at a vaccination delivery location and an action plate. The action plate can be coupled to the vaccination device such that the action plate is positioned next to the vaccination delivery location. The action plate can include an action button, wherein the action button is configured to receive a day-old chick presented to the action plate in a predetermined loading position, receive a press of the action button, and in response to pressing the action button, cause the vaccination needle to extend from the vaccination device at the vaccination delivery location to deliver a subcutaneous injection to the day-old chick.

An apparatus includes a housing, a medicament container, an actuator, and a biasing member. The actuator is configured to move the medicament container within the housing when the actuator is moved from a first configuration to a second configuration. The actuator includes a gas container and a puncturer. When the actuator is in the first configuration, a portion of the puncturer is disposed apart from the gas container. When the actuator is in the second configuration, the portion of the puncturer is disposed within the gas container. The gas container has a longitudinal axis offset from a longitudinal axis of the medicament container. The biasing member is configured to bias the actuator toward the second configuration.

Ingestible devices with a relatively large payload volume or sample volume, as well as related components, systems and methods, are disclosed.

An orientation independent delivery device. The delivery device includes a gas chamber, a delivery chamber, a gas cell, and a delivery aperture. The gas chamber includes a gas-side rigid portion and a gas-side flexible barrier. The gas-side flexible barrier is sealed to the gas-side rigid portion. The delivery chamber includes a delivery-side rigid portion and a delivery-side flexible barrier. The delivery-side flexible barrier is sealed to the delivery-side rigid portion and is oriented adjacent to the gas-side flexible barrier. The gas cell is coupled to the gas-side rigid portion of the gas chamber. The gas cell increases a gas pressure within the gas chamber to expand the gas-side flexible barrier. Expansion of the gas-side flexible barrier applies a compressive force to the delivery-side flexible barrier allowing a delivery material to escape from the delivery chamber.

An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70 and 90 with respect to the injection axis (B).

A drug delivery device configured to provide a dose of medicament is disclosed. The drug delivery device includes a main housing, a syringe arranged in the main housing, and a pneumatic power pack arranged in the main housing. The pneumatic power pack includes a pressurized gas source storing pressurized gas, a valve for the pressurized gas source, a sleeve having an inner wall, and a plunger. The sleeve is configured to receive pressurized gas released from the pressurized gas source. The plunger is in sliding gas-tight engagement with the inner wall of the sleeve. Upon activation of the valve, the valve releases the pressurized gas, and the released pressurized gas flows into the sleeve and propels the plunger in a distal direction with respect to the sleeve and the syringe, so as to eject medicament from the syringe.

An apparatus includes a housing, a medicament container, an actuator, and a biasing member. The actuator is configured to move the medicament container within the housing when the actuator is moved from a first configuration to a second configuration. The actuator includes a gas container and a puncturer. When the actuator is in the first configuration, a portion of the puncturer is disposed apart from the gas container. When the actuator is in the second configuration, the portion of the puncturer is disposed within the gas container. The gas container has a longitudinal axis offset from a longitudinal axis of the medicament container. The biasing member is configured to bias the actuator toward the second configuration.

Devices that allow serially controlled delivery of room air for practice inhalation and breath-hold procedures and a different (image contrast) gas for inhalation for a medical procedure include an actuator that is controllably, pneumatically operated by a user via a length of conduit.

A pneumatic needle-free injection device restores pressured air in a pressure room to deliver high pressure air instantaneously, so as to inject a dose subcutaneously, intradermally, and intramuscularly, accelerating an absorption process of skins. The device can be further linked to a high-pressured air container for portable usage.