A biosensor includes an optical circuit that obtains a plurality of photoplethysmography (PPG) signals from light at different wavelengths that is reflected from or transmitted through tissue of a user. A processing circuit determines a measurement value for a nitric oxide (NO) level in blood flow using first and second PPG signals and determines an insulin response from caloric intake using the measurement value for the NO level in blood flow. The first PPG signal is obtained from light at a wavelength having a high absorption coefficient for NO in blood flow and the second PPG signal is obtained from light at a second wavelength having a low absorption coefficient for NO in blood flow. The processing circuit also determines one or more phases of digestion using at least one or more of the plurality of PPG signals.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.

An electronic cigarette includes a liquid supply including liquid material, a heater operable to heat the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol, a wick in communication with the liquid material and in communication with the heater such that the wick delivers the liquid material to the heater, at least one air inlet operable to deliver air to a central air passage upstream of the heater, and a mouth end insert having at least two diverging outlets. The electronic cigarette can also include an air flow diverter which directs incoming air away from a heating zone of the heater.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.

Drug supply units are disclosed which comprise substrates having a plurality of holes formed therein.

Drug supply units are disclosed which comprise substrates having a plurality of holes formed therein.

An aerosol generating device is provided, including a storage portion to store an aerosol-forming substrate and having an outer housing and an internal passageway, the portion forming a reservoir for the substrate between the housing and the passageway; a vaporizer including an electric heater to heat the substrate to form an aerosol, the vaporizer at least partially inside the passageway; and a porous interface at least partially lining the passageway to convey the substrate towards the vaporizer, the device being electrically operated, the heater including first and second electrical connection portions, and a heating filament therebetween, a cylindrical shape of the connection portions and the filament define a cylindrical bore, an air flow route is defined through the bore, and the first connection portion being a first cylindrical electrical connection portion, the second connection portion being a second cylindrical electrical connection portion, and the filament being a cylindrical heating element.

An electronic cigarette includes a liquid supply including liquid material, a heater operable to heat the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol, a wick in communication with the liquid material and in communication with the heater such that the wick delivers the liquid material to the heater, at least one air inlet operable to deliver air to a central air passage upstream of the heater, and a mouth end insert having at least two diverging outlets. The electronic cigarette can also include an air flow diverter which directs incoming air away from a heating zone of the heater.

In one embodiment, the electronic vaping device includes a cartridge and a battery section. The cartridge and the battery section are connectable so as to define an air inlet between a portion of the cartridge and a portion of the battery section.

The present invention provides a device for delivering a predetermined amount of at least one substance to a body orifice of a subject; comprising: a. a container for containing said at least one substance; b. a delivery end for placement in proximity to said orifice, said delivery end being in fluid communication with said container; c. a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d. a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; e. a fluid tight chamber.