A dispensing device which disperses medicate through a needle across a zone within a body. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a reservoir in fluid communication with the needle, positioned within the housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with the reservoir-connecting conduit, and a linear drive attached to the needle or to the needle-receiving member. The fluid drive impel fluids from the second reservoir to the reservoir-connecting conduit and thus drives the therapeutic agent from the reservoir during the linear displacement of the needle towards the housing. Fluid communication from the therapeutic agent reservoir to the needle is maintained by the tubing during operation of the linear drive.

A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.

An electronic cigarette or vaporizer may include a shell and a cartomizer receivable within a chamber within a portion of the shell. A basin may be included in the cartomizer to hold a vaporizable fluid, dry substance, or other vaporizable substance such as a wax. A heating element may be provided within the basin which may have a flexible non-conductive material and a flexible conductive material.

The Bone Dust Trap for collecting bone dust during various surgical procedures for subsequent bone graft implantation. The device includes cylindrical housing unit covered with the lid, attached to the central pipe with the porous tip. The pipe connects the cyclone forming mechanism and filtrating membrane, located at the lower part of the central pipe. The membrane interlinks with the plurality of porous plates located along the walls of the cylinder. The cyclone forming mechanism, consisting of the inlet port with conical jet and the spiral helix, creates spiral movement of the incoming fluid. The liquid is further directed towards the 2-stage filtrating system with the said porous plates, where larger bone particles are accumulated, and then to the filtrating membrane, which collects smaller particles. The fluid is extracted through the central pipe. The lid can be removed to collect the bone particles from plates and membrane.

A device for delivering a compound to the olfactory region of the nasal cavity includes an actuator body and a tip that removably couples to the actuator body. The actuator body includes a propellant channel in fluid communication with a propellant canister. The tip includes an exit channel, an inlet interface, one or more grooves, and an outlet orifice. The exit channel extends between a proximal end and a distal end of the tip. The inlet interface is positioned about a distal end of the exit channel, and the inlet interface couples to a compound container containing the compound. The grooves are positioned about the inlet interface and direct propellant from the propellant channel into the compound container, thereby agitating and entraining the compound in the compound container with the released propellant. The compound and the propellant then travel through the exit channel and out the outlet orifice.

Various spirometer-inhaler systems and devices are disclosed. The spirometer-inhaler system may estimate physiological parameters of a user based on the user's inhaled and/or exhaled breaths received by the spirometer-inhaler device. The spirometer-inhaler device may comprise one or more flow paths. A first flow path may direct medication from a medicine canister to an opening of the device. A second flow path may direct a user's exhaled breath from the opening of the device to one or more flow measurement devices.

Methods and systems for delivery of pulsated air to a user using a device including a flow generator to generate a continuous air flow, a first actuator comprising a pulsated flow delivery mechanism configured to generate a pulsated air flow from the continuous air flow based on a pre-determined duty cycle to vary a frequency of the pulsated air flow, a user interface configured to generate and deliver vortices of pulsated air to the user at the frequency of the pulsated air flow, and a set of tubing to couple the flow generator, the first actuator, and the user interface.

The present invention provides a dry powder inhaler comprising: a reservoir containing a dry powder formulation and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator for breaking up agglomerates of the dry powder medicament; and a delivery passageway for directing an inhalation-induced air flow through a mouthpiece, the delivery passageway extending to the metered dose of medicament, wherein the formulation comprises an inhalable β.sub.2-agonist having a particle size distribution of d1O<1 μπ.Math.=1-3 μπ.Math., d90=3.5-6 μm and NLT 99% 10 μm and a lactose carrier.

An apparatus for suctioning matter expelled during treatments involving an orifice of a patient; the apparatus includes a suction head, a conduit attached to the suction head and a suction device for attaching the conduit thereto, thereby putting the suction head in communication with the suction device. The conduit includes a flexible and bendable body that is easily manipulated into different positions and supports the suction head about the orifice of the patient during treatment. Preferably, the orifice is a mouth, and the treatment is a dental treatment. In this embodiment, the apparatus provides for the hands-free suction of aerosols and/or saliva and blood splatter produced from the mouth of the patient during the dental treatment.

Concurrent treatment of obstructive sleep apnea and hypertension in a patient, via a pressure generating device, includes providing a flow of treatment gas to an airway of a patient in accordance with an initial set of flow parameters with respect to an obstructive sleep apnea mode. Responsive to determining that the patient has achieved stable breathing while receiving the flow of treatment gas, the flow parameters are increased above the initial set of flow parameters with respect to a hyper-ventilation mode. The flow of treatment gas is then provided to the airway of the patient in accordance with the increased flow parameters for a predetermined period of time. The increased flow parameters are configured to bring the patient's breath into accordance with target patient breath parameters configured to inflate the patient's lungs beyond a threshold for activating pulmonary stretch receptors of the airway of the patient.