A device for delivering a predetermined amount of at least one substance to a body orifice of a subject includes a) a container for containing said at least one substance; b) a delivery end for placement in proximity to the orifice, the delivery end being in fluid communication with the container; c) a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d) a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; and e) a fluid tight chamber.

A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial. The system also includes a vial adapter assembly including a first needle configured to penetrate a septum of the fluid vial for fluidly coupling the pump mechanism to the fluid vial and a second needle having a first end configured to penetrate the septum of the fluid vial and a second end configured to penetrate a septum of the reservoir of the infusion pump assembly to allow transfer of fluid from the fluid vial to the reservoir of the infusion pump assembly in response to air being pumped into the fluid vial and a needle carriage adapted to carry the first needle and the second needle, wherein the needle carriage slidably attached to the interior of the vial adapter assembly, wherein the needle carriage adapted to slide from a vial end of the vial adapter to a receptacle end of the vial adapter.

Described herein are systems and methods for performing peritoneal dialysis. According to one aspect, the disclosure provides a sterile interface connection for connecting a water purification system to a disposable source of dialysate concentrates. The sterile interface connection can include a chamber comprising an inlet adapted to be connected to the water purification system on a proximal end and a valve on a distal end. The sterile interface connection can also include spring-loaded needle disposed in the chamber. The spring-loaded needle can move between a retracted configuration in which the spring-loaded needle is fully retracted into the chamber and the valve is closed and sealed, and an extended configuration in which the spring-loaded needle extends through the valve into the disposable source of dialysate concentrates.

Method and device for controlling the quantity of liquid contained in a cartridge for an aerosol generating device, wherein the cartridge has a container and a liquid contained in the container and wherein, according to which is measured the quantity of liquid contained in the cartridge; and compared the quantity of liquid with a reference quantity of liquid.

A reservoir refill system for an electronic vaping device includes a refill container and a reservoir. The refill container contains a pre-vapor formulation. The refill container includes a body, an opening in the body, and a first interlocking ring including at least one groove or at least one protrusion therein. The reservoir is configured to contain a pre-vapor formulation and includes a reservoir body, an opening in the reservoir body, and a second interlocking ring including at least one groove or at least one protrusion therein at an opening of the reservoir. The first interlocking ring is configured to mate with the second interlocking ring so as to release the pre-vapor formulation from the refill container to the reservoir.

A system for sterilizing a drug delivery device includes a drug delivery device having a first self-healing seal configured to seal a fluid reservoir disposed within the drug delivery device. A sealable container is configured to receive the drug delivery device therein. The sealable container has a base portion and a cover portion. The cover portion has a second self-healing seal positioned to align with the first self-healing seal when the drug delivery device is disposed within the sealable container. A fill port includes a fill path, the fill path being configured to pass through the first and second self-healing seals to fluidly couple the fill port to the reservoir of the drug delivery device. Other systems, methods, and devices of sterilization are also disclosed.

A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.

A filling head (20) for filling a container (22) includes a receptacle (24). The receptacle (24) includes an interior surface (26) configured to receive a powder (28) and having a plurality of openings (34) disposed therein to allow passage of the powder (28); and an exterior surface (52). The exterior surface (52) of the receptacle (24) has a plurality of raised surfaces (54), each of the plurality of raised surfaces having a plurality of openings (56) aligned with at least one of the plurality of openings (34) of the interior surface (26) to allow passage of the powder (28) from the receptacle (24) to the container (22). Methods of filling a container (22) are also provided.

A syringe-shaped spraying device includes: a syringe-shaped spraying device main body including a barrel that stores a liquid medicine, a plunger having a front end inserted in the barrel with a gasket being attached to the front end, and a nozzle that is provided with a spraying hole for spraying the liquid medicine and that is connected to a front end of the barrel; a vial adapter having a transfer needle to pierce a vial that stores a liquid medicine so as to suction the liquid medicine; and a connection adapter that is attached to the syringe-shaped spraying device main body and that connects the vial adapter to the syringe-shaped spraying device main body.

A contained liquid system for use with a refillable aerosol delivery device is provided. The contained liquid system includes an aerosol delivery device having an adapter therein for receiving aerosol precursor composition within a reservoir of the aerosol delivery device, and a container of aerosol precursor composition having a corresponding adapter therein for transferring aerosol precursor composition from the container. The adapter and the corresponding adapter are removably, sealably connectable for refilling the aerosol delivery device with aerosol precursor composition. The adapter engages a valve of the corresponding adapter and includes a body defining separate and distinct filling airflow ports. The filling port transfers aerosol precursor composition from the container into the aerosol delivery device. The airflow port enables a flow of air through at least the portion of the aerosol delivery device when the adapter and valve are disengaged.