Devices and methods for wound treatment are disclosed. A chamber may define a treatment space having an interior engineered surface including a plurality of structures configured to provide pathways for the distribution of negative pressure and to exert mechanical stress on a wound. One or more tubes may be in fluid communication with the treatment space to facilitate the application of negative pressure, the introduction of therapeutic agents, and the removal of wound material. Therapeutic agents may be formulated with a gel, for example, a hydrogel, a hydrocolloid, alginate, methyl cellulose, gelatin or any other gels for sustained-release and enhanced usability. A wound fluid collection device including an absorbable material may interface with the wound treatment device to facilitate the collection and disposal of wound material.

Apparatus and methods detect sleep disordering events. The apparatus may be configured to access one or more physiological signals generated by one or more sensors. The apparatus may be configured to detect, from the one or more physiological signals, seed events suggestive of sleep disordering events. The apparatus may be configured to compute features indicative of patterns within portions of the one or more physiological signals that are associated with the detected seed events. The apparatus may be configured to apply to a classifier, the computed features indicative of patterns of the seed events. The classifier may be trained to compute a degree of fit of the computed features to learned repetitive patterns of sleep disordering events. The apparatus may be configured to output an identification of sleep disordering event(s) corresponding with the seed events based on the computed degree of fit determined by the classifier.

A system for facial remodeling, including a device and methods of use, is provided. The system combines a topical composition configured to restore elastin, hyaluronan, or both to the skin and subcutaneous soft tissues of the face and neck with a facial mask to support and, in some embodiment, compress the tissue, to enhance and preserve the tissue remodeling effects of the composition. Some versions of the facial mask device include a means for electrically grounding the skin and soft tissues of the face, neck, and head, wherein the user receives local tissue benefits of earthing. In some versions, the facial mask is formed by combining different elements and configurations to compress skin and underlying soft tissue, bias areas of skin and soft tissue in a cranial direction, and ground the face, head, and neck tissues.

A nose vent plug, and a nasal mask for anesthesia. The nose vent plug comprises a base (1) and two nasal plugs (2) symmetrically provided on the base (1); the inner edges of the two nasal plugs (2) form a gap (3) into which a nasal septum is embedded; each nasal plug (2) comprises an insertion portion (4) and a pressing portion (5); the outer diameter of the pressing portion (5) is larger than that of the insertion portion (4); the bottom end of the pressing portion (5) is integrally formed on the base (1); the insertion portion (4) is integrally formed on the top of the pressing portion (5); an air hole (6) passing through the pressing portion (5) and the base (1) is provided in the insertion portion (4). The insertion portion (4) of the nose vent plug is shorter, and has fewer parts entering a nostril compared with an existing structure, such that human comfort is improved; moreover, the inner-outer contour shape of the nose vent plug is improved, the inner contour of the nose vent plug is used to fit the nasal septum, the pressing portion (5) is used to plug the nostril, and pressing the base (1) against a nasal cavity can strengthen the air tightness of the nasal cavity, such that on the premise of ensuring human comfort, the air tightness between a ventilation structure and nostrils is improved, thereby avoiding air leakage.

An arousal level control apparatus calculates a setting value of a control device under a constraint condition using an arousal level optimization model so that a value of an objective function is maximized. The control device affects a physical quantity of a surrounding environment that affects arousal level of a subject. The arousal level optimization model includes the constraint condition and the objective function. The constraint condition includes a physical quantity prediction model, an arousal level prediction model, and a setting value range condition that the setting value is within a predetermined range. The physical quantity prediction model is an explicit function that includes the physical quantity and the setting value as explanatory variables and has a predicted value of the physical quantity as an explained variable.

Provided herein is an injectable composition including, in some embodiments, a soft-tissue augmenting agent and a vehicle for the soft-tissue augmenting agent formulated for augmenting one or more soft tissues of a human or animal. Also provided herein is a soft-tissue augmenting kit including, in some embodiments, a syringe and the injectable composition formulated for augmenting one or more soft tissues of a human or animal. Also provided herein is a method for augmenting one or more soft tissues of a human or animal including, in some embodiments, injecting the injectable composition into the one or more soft tissues of the human or animal.

A patient interface includes a first body that rests on a first portion of a patient's face, a second body that rests on a second portion of the patient's face, and a bridge linking the first and second bodies. The patient interface includes an attachment structure that couples with a complementary fixation structure positioned on the patient's face to secure the patient interface to the patient's face. The complementary fixation structure can be configured to assist in retaining a feeding tube in position relative to the patient's face or to the patient interface.

A patient interface includes a plenum chamber pressurizable to a therapeutic pressure, a seal-forming structure configured to form a seal against the patient's face, and a positioning and stabilising structure configured to provide a force for maintaining the seal-forming structure in a therapeutically effective position. The patient interface also includes an RPT device connected directly to the plenum chamber. The PRT device includes an electric blower for providing airflow at the therapeutic pressure. The positioning and stabilising structure supports at least part of the weight of the RPT device. The patient interface may also include an electrical power source electrically connected to the RPT device.

The invention relates to a positioning and stabilising structure for a patient interface, wherein the positioning and stabilising structure comprises a headgear structure with a pre-defined shape, and a patient interface comprising the positioning and stabilising structure. The invention also relates to methods of manufacturing the headgear structure with a pre-defined shape.

A system comprising a handpiece and drive system configured to removably couple to a proximal end of a housing. A scalpet assembly is configured to removeably couple to the housing, and includes a scalpet array comprising at least one scalpet configured for rotation. The scalpet array is configured to harvest dermal plugs via fractional resection. A collection chamber is configured to collect the dermal plugs, and to house formation of an injectable filler by mincing the dermal plugs, and mixing the dermal plugs with a carrier. The injectable filler is configured for bulk fill. The collection chamber includes a loading port, and a cannular syringe is configured to mate with the loading port to receive the injectable filler, and to deliver the injectable filler for the bulk fill.