A method of providing repetitive motion therapy comprising providing access to audio content; selecting audio content for delivery to a patient; performing an analysis on the selected audio content, the analysis identifying audio features of the selected audio content, and extracting rhythmic and structural features of the selected audio content; performing an entrainment suitability analysis on the selected audio content; generating entrainment assistance cue(s) to the selected audio content, the assistance cue(s) including a sound added to the audio content; applying the assistance cues to the audio content simultaneously with playing the selected audio content; evaluating a therapeutic effect on the patient, wherein the selected audio content continues to play when a therapeutic threshold is detected, and a second audio content is selected for delivery to the patient when a therapeutic threshold is not detected.

System and methods for stimulating cartilage formation at a first tissue site through a second tissue site is presented. The system includes a fluid source for supplying a therapeutic solution, a reduced pressure source for supplying reduced pressure, a fluid delivery manifold for deploying adjacent the first tissue site, and a vacuum manifold for deploying within the second tissue site. The fluid delivery manifold extends between a proximal end fluidly coupled to the fluid supply and a distal end having at least one aperture for delivering the therapeutic solution to the defect adjacent the articulating surface of the first tissue site. The vacuum manifold extends between a proximal end fluidly coupled to the reduced pressure source and a distal end having at least one aperture for delivering the reduced pressure to the first tissue site adjacent the opposing surface of the first tissue site.

Described herein are noninvasive electrical stimulation devices, systems and methods for stimulation of the Vagus nerve through its auricular branch to provide beneficial physiological responses in subjects, including alleviation, mitigation or elimination of symptoms of various disorders, including metabolic and inflammatory disorders.

A narrow-orifice foreign body extraction device configured as a unitary article comprises a volumetric enclosure bounded by a frustoconical cone, which has inner and outer surfaces and an intermediate section positioned between an apertured cap section and an apertured base section. The inner surface defines a boundary of an interior chamber of the volumetric enclosure, and the inner and outer surfaces define between them a cone wall. An adhesive material is secured to at least part of the inner or outer surfaces at the cap section and comprises an apertured portion and a tail portion. The apertured portion has one or more adhesive apertures and adhesive-covered opposing inner and outer side surfaces, and the tail portion has an adhesive-covered inner tail surface extending along and bonding to at least part of the outer surface at the cap section to secure the adhesive material to the cap section.

A system for reducing a kinetosis effect in at least one passenger of a vehicle comprises at least one set of headphones having two loudspeakers and at least one first ear bud, wherein the at least one set of headphones is designed, at least by means of a sensor device integrated in the first ear bud, to detect the kinetosis effect in the auditory canal of the respective passenger via measurement of the body temperature and to provide acoustic signals by means of the two loudspeakers in order to reduce the kinetosis effect of the passenger depending on the kinetosis effect detected. Forces acting on the passenger and their countenance can also be measured.

An earplug (1) for administering a fluid agent into an ear canal is provided. The earplug (1) comprises a first part (10) adapted for insertion in the ear canal. The first part comprises an elongated member (11) having a chamber (12) for containing the fluid agent, the chamber (12) having at least one outlet (13) at a proximal end (14) of the elongated member (11); and a malleable member (17) disposed laterally of the elongated member (11). The earplug (1) further comprises a second part (20) comprising a piston (21). The piston (21) has a first end (22) which is insertable in the elongated member (11), and a second end (23) which has a push member (24). The piston (21) is displaceable from a first position (A) distally of the chamber (12) to a second position (B) within the chamber (12), such that the fluid agent is injected from the chamber (12) through the outlet (13) into the ear canal.

Presented herein are techniques for localized release of systemically circulating therapeutic substances, which combine many of the advantages of systematic and localized administration, while eliminating many of the associated drawbacks. More specifically, in accordance with the techniques presented herein, an electro-responsive biomaterial is systemically administered to a recipient of an electrically-stimulating implantable medical device. The electro-responsive biomaterial comprises a therapeutic substance that is only activated (e.g., released) in the presence of an electromagnetic field generated by the electrically-stimulating implantable medical device.

An ear canal medication applicator including a tympanogram ear canal occlusion earpiece operatively connected to a bulb insufflator through a body, and a syringe operatively connected to an IV line, wherein the syringe is operatively attached to the body and the IV line is threaded through a portion of the tympanogram ear canal occlusion earpiece. A method of treating the ear canal, by providing a dual application of medication at two different locations in the ear canal of an individual and treating the ear canal.

A method of neurostimulation may include delivering an electrical signal to a plurality of electrodes connected to a patient. The electrical signal may include an amplitude and a carrier frequency. The method may include modulating the electrical signal based on an audio waveform. In some embodiments, the modulating may include modulating at least one of the amplitude and the carrier frequency based on the audio waveform to modulate the electrical signal.

In one embodiment, a fluid storage device includes a rigid outer housing that defines a septum cavity, a reservoir cavity, and a channel that extends between the two cavities, the outer housing further defining an outlet in fluid communication with the reservoir cavity, a septum provided within the septum cavity, the septum being made of an elastic polymer and facilitating refilling of the fluid storage device, and a thin, collapsible membrane that does not generate significant restoring forces when it is deformed as fluid is drawn from the reservoir cavity and, therefore, does not completely or partially return to its initial non-deformed shape even if the outlet of the device remains open after doses are administered.