Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

A medical tool includes, a deflectable distal end, at least a pull wire, and a coupling element. The at least pull wire has a first end coupled to the distal end of the medical tool, and configured to be moved for deflecting the distal end. The coupling element is coupled to a second end of the pull wire and having at least two boreholes configured to receive at least two respective rods traversing therethrough. The coupling element is configured to be moved along a rotation axis of a rotatable element coupled thereto, and the boreholes and the respective rods are configured to prevent rotation of the coupling element.

A shunt device for shunting cerebrospinal fluid (CSF) from a CSF containing space to a sinus system cavity comprises a tubular inlet element, a flow restricting part, and a tubular outlet element having an outlet end with an outlet opening for insertion in the sinus system cavity, and a one-way valve preventing flow in a direction from the outlet opening to the inlet opening. The shunt device further comprises a distancer, said distancer being provided at the outlet end of the tubular outlet element.

Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat.

The present invention relates to a dual-body drug administration device which administers drugs and removes mucus from the paranasal sinus through the nostrils in order to prevent or treat a paranasal sinus disease and, more specifically, to a device in which two injectors having adapters coupled thereto are integrally fixed by a fixing holder, the adapters of the fixed injectors are simultaneously brought into contact with both the nostrils, and then negative pressure is generated in the nasal cavity to pull out mucus from the paranasal sinus or administer a drug to the paranasal sinus.

The present disclosure provides a balloon dilation catheter that includes a handle (102), a substantially rigid inner guide member (108) coupled to the handle, a shaft (118) arranged over the inner guide member, a balloon (120) coupled to the inner guide member, and a polymer ball tip (122) positioned at a distal end of the balloon. To treat a sinus drainage pathway of a subject using the balloon dilation catheter, the substantially rigid inner guide member is positioned into the drainage pathway of the sinus of the subject via a nasal passageway. The balloon is then inflated to expand or otherwise remodel the drainage pathway.

A system includes a medical probe and a position-tracking system. The medical probe includes a distal end, and one or more distal magnetic position sensors. The medical probe further includes a proximal-end assembly, and one or more proximal magnetic position sensors. The position-tracking system includes a memory, which is configured to hold values indicative of known relative positions between the distal magnetic position sensors and the proximal magnetic position sensors. The position-tracking system includes a processor, which is configured to receive one or more signals indicative of estimated positions of the proximal magnetic position sensors and of the distal magnetic position sensors, as measured by the position-tracking system, and to initiate a responsive action in response to detecting a discrepancy between the known relative positions and the estimated positions.

In another example, a bioresorbable implant for use in a nasal region includes one or more bioresorbable polymers, and a pharmaceutical composition coupled to the one or more bioresorbable polymers. A release rate of the pharmaceutical composition is related to a degradation rate of the one or more bioresorbable polymers.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

A surgical system comprising a catheter comprising an irrigation tube, a suction tube, an occlusion balloon disposed about the irrigation tube and suction tube, and a console in operative communication with the irrigation tube and the suction tube. The surgical system also comprising a remote operations unit in communication with the console via a connector, wherein an input to the remote operations unit is communicated to the console, which in turn acts to operate the irrigation tube and suction tube in a manner corresponding to the input.