Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.

Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.

A neurosurgical apparatus includes a guide device and a neurosurgical instrument is disclosed. The guide device includes a tube for insertion into the brain and a head attached to the proximal end of the tube for affixing the guide device to a hole formed in the skull. The head has a passageway therethrough in communication with the bore of the tube such that the bore of the tube and the passageway through the head define an internal channel through which a neurosurgical instrument can be passed into the brain of the subject. The neurosurgical instrument is for insertion to a desired brain target through the internal channel of the guide device. The apparatus includes one or more sealing elements for providing a fluid tight seal between the internal channel of the guide device and the exterior of the neurosurgical instrument to prevent fluid leakage from guide tube.

Endovascular drug delivery systems and methods are disclosed herein for delivering a therapeutic agent to the intracranial subarachnoid space of a patient, and/or deploying an endovascular drug delivery device distal portion in the intracranial subarachnoid space and a portion of the drug delivery device body in a dural venous sinus such that a therapeutic agent is delivered from the deployed drug delivery device into the intracranial subarachnoid space.

An implantable intracranial pulse pressure modulator for treating hydrocephalus in patients of all ages is disclosed as well as a system and method for use of the same. In one embodiment of the implantable intracranial pulse pressure modulator, two one-way valves are interposed in parallel, opposing orientations between a vestibule and a chamber. One of the one-way valves, in response to systole, provides fluid communication from the vestibule to the chamber such that a small aliquot of cerebrospinal fluid (CSF) is displaced from a cerebral ventricle into a ventricular catheter, thereby reducing intraventricular systolic pressure. The other one-way valve, in response to diastole, provides fluid communication from the chamber to the vestibule such that the same volume of CSF is reintroduced into a cerebral ventricle, thereby increasing intraventricular diastolic pressure. Together, both processes work synergistically to reduce intraventricular pulse pressure in order to treat hydrocephalus.

Methods and apparatuses for transdermal electrical stimulation. Described herein are single-use or limited-use TES apparatuses and methods of using them that include an integrated (e.g., flex-circuit) electrode assembly and controller apparatus including a waveform generator and power supply. Also described herein are TES apparatuses including a cord or wire having current control circuitry and configured to connect a mobile computing device (e.g., smartphone or wearable electronics) to an electrode assembly. Finally, also described herein are intermediate apparatuses including a flex-circuit electrode assembly including a waveform generator but receiving power from a cable connected to a mobile computing device.

An implantable intracranial pulse pressure modulator for treating hydrocephalus in patients of all ages is disclosed as well as a system and method for use of the same. In one embodiment of the implantable intracranial pulse pressure modulator, two one-way valves are interposed in parallel, opposing orientations between a vestibule and a chamber. One of the one-way valves, in response to systole, provides fluid communication from the vestibule to the chamber such that a small aliquot of cerebrospinal fluid (CSF) is displaced from a cerebral ventricle into a ventricular catheter, thereby reducing intraventricular systolic pressure. The other one-way valve, in response to diastole, provides fluid communication from the chamber to the vestibule such that the same volume of CSF is reintroduced into a cerebral ventricle, thereby increasing intraventricular diastolic pressure. Together, both processes work synergistically to reduce intraventricular pulse pressure in order to treat hydrocephalus.

In some examples, a burr hole cap assembly includes one or more markers that indicate a rotational orientation of a therapy delivery member relative to the burr hole cap assembly, where the therapy delivery member extends through an opening defined by the burr hole cap assembly. In addition, in some examples, the burr hole cap assembly includes a feature that indicates the rotational orientation of the therapy delivery member after the therapy delivery member is implanted in the patient. The feature can include the one or more markers in some examples.

Endovascular drug delivery systems and methods are disclosed herein for delivering a therapeutic agent to the intracranial subarachnoid space of a patient, and/or deploying an endovascular drug delivery device distal portion in the intracranial subarachnoid space and a portion of the drug delivery device body in a dural venous sinus such that a therapeutic agent is delivered from the deployed drug delivery device into the intracranial subarachnoid space.

The present invention provides a skull implant-type automatic fluid drain device comprising: a body having a first port to be connected to a catheter, a second port provided opposite the first port, and a flow passage connecting the first port and the second port; a separation member for separating the flow passage into first and second sub-channels; a first valve fixed to the separation member and provided to allow the movement of a fluid that moves from the first port to the second port in the first sub-channel; and a second valve fixed to the separation member and provided to allow the movement of a fluid that moves from the second port to the first port in the second sub-channel, wherein each of the first valve and the second valve has an inflow end portion that is open and a discharge end portion provided in a closed state such that the same is selectively opened at an allowed opening pressure or higher; each of the first valve and the second valve is configured such that the inner flow sectional area decreases along the direction of allowed movement of the fluid passing through each of the inflow end portion and the discharge end portion; and the allowed opening pressures of the first valve and the second valve are set to differ from each other.