Systems and methods are provided for controlled infusion, effusion, and/or perfusion of biological/biocompatible liquid to and from a body cavity of a subject, and for continuous control of body cavity parameters, for example in neuro-intensive care. Systems and methods may relate to estimating compliance and pressure/volume changes within a body cavity. A bio-liquid replacement system may include a sensor for continuously measuring at least one parameter associated with the cavity, a pump for infusing the liquid into and aspirating the liquid out of the cavity, a processing unit continuously calculating at least one physiological parameter based on the measured parameter, and defining a target parameter slightly offset from the physiological parameter, and a flow controller controlling said pump unit based on the target parameter and the induced offset such that continuous compensatory changes are induced in the liquid volume. The processing unit continuously estimates the body cavity compliance.

The present disclosure provides an apparatus for intracranial drug injection including a body unit having a through-hole extending between a first opening in a topmost surface and a second opening in a bottommost surface, a cap unit having a shape corresponding to at least a part of an inner surface of the through-hole and being inserted into the first opening to cover the first opening, and a tube unit having one end coupled to the second opening and another end extending toward an affected brain lesion.

A system and method of accurately measuring a pressure (Pp) within a human brain using totally-implanted or partially-external hardware. The system includes a first pressure transducer configured to measure a cerebrospinal fluid pressure (Pcsf) within a ventricle of a brain, a second pressure transducer configured to indirectly measure a second pressure (Pp) within a space of the brain, and an adjustable implanted valve controller configured to calculate the effective differential pressure (Pei=Pcsf−Pp) between the measured pressures Pcsf and the Pp and determine whether the effective differential pressure measurement represents a true secondary pressure.

The METHODS, APPARATUSES AND SYSTEMS FOR INSTILLING STEM CELLS AND PHARMACEUTICALS INTO THE HUMAN VENTRICULAR SYSTEM (hereinafter “Ventricular Stem Cell System” or “VSCS”) disclosed herein provide safe and effective techniques for obtaining stem cells and instilling any type of stem cell or pharmaceutical agents into the human ventricular system for treatment of various diseases, including neurodegenerative diseases such as Parkinson's, Alzheimer's, Multiple Sclerosis, and others.

The present disclosure describes for at least two zones of selective thermal therapy of the body. Three-port extracorporeal circuits are described that can be used to establish at least two zones of selective thermal therapy of the body. The example three-port extracorporeal circuit includes a branching section that provides for setting the temperature of blood injected into two different portions of the body at differing temperature levels, to provide. at least two zones of selective thermal therapy.

A minimally invasive system for monitoring and treating high intracranial pressure levels resulting from traumatic brain injury comprises an intravenous access device, an elongate member, a console, and an aspiration and injection catheter. The system is capable of monitoring pressure levels and relocating fluid from the brain to another part of the patient's body to sustain overall constant fluid volume. The method of using the minimally invasive system is also described.

An integrated guidewire includes a wire and a flexible tube. The wire is sized and shaped to move in an anatomical material transportation system of a patient. The flexible tube is sized and shaped to move in the anatomical material transportation system, having proximal and distal ends, the proximal-end is coupled to a device external to the patient, the flexible tube is configured to transfer fluids between the distal-end and the device, and the wire and the flexible tube are intertwined with respect to one another.

Described are methods, systems, devices for facilitation of intraluminal medical procedures within the neurovasculature. A catheter advancement device includes a flexible elongate body having a proximal portion coupled to a proximal end region of the flexible elongate body and extending proximally to a proximal-most end of the catheter advancement element. A hardness of the flexible elongate body transitions proximally towards increasingly harder materials up to the proximal portion forming a first plurality of material transitions. At least a portion of the flexible elongate body is formed of a plurality of layers including a reinforcement layer. An outer diameter of the flexible elongate body is sized to be positioned coaxially within a lumen of a catheter such that a distal tip portion of the flexible elongate body extends distally beyond a distal end of the catheter to aid in delivery of the catheter to an intracranial vessel.

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and/or regulate a temperature of the bodily fluid flowing therethrough.

An irrigation function-equipped suction device including a suction device body, a suction path, an irrigation path and a flexible tube. With communication or closing of the suction path and the flexible tube by a first switch mechanism, the irrigation path and the flexible tube are caused to be closed off from each other or to communicate with each other by a second switch mechanism. The first switch mechanism is provided in a first section inside the suction device body, and the second switch mechanism is provided inside the irrigation path between the conversion mechanism and the flexible tube. The closing valve included in the second switch mechanism is disposed at a position on a side opposite to the flexible tube relative to the first switch mechanism and the conversion mechanism.