A stimulation application apparatus includes a substrate, a stimulation application member provided on one surface of the substrate to apply a stimulation to a site, and a stimulation imposition layer provided on another surface of the substrate opposed to the first surface to impose the stimulation. The site includes at least one area selected from a group of (F) site that intersects the perpendicular line of the medial malleolus on an extension line of the medial margin on os metatarsale primam 1 and 2 in foot sole, and (L) incisurasive foramen supraorbitalis site, and (K) site where the lintersection of the line connecting an augulus oculi medialis of eye and L site, and perpendicular of an augulus oculi lateralis of eye is located, and (M) site of augulus oculi lateralis located above 1 horizontal finger from center of the line where connect the inner end of left and right eyebrow.

In a method for diagnosing, validating and treating a patient having lesions in both arteries of left and right lower limbs. By determining that a harder lesion to be treated first, catheters and an operation time can be reduced is to be treated first on a priority basis based on diagnostic data, deciding that a softer lesion is to be treated next, then treating the lesions substantially continuously.

For treatment of a patient who has a lesion in each of left lower limb artery and right lower limb artery, lesions at both sides can be rather easily and completely treated. A catheter is introduced from an artery of an arm of the patient, and an atherectomy catheter is used for a lesion at one side and continuously used for a lesion at the other side without being extracted to the outside of a human body, and thus damage of an excision portion of the atherectomy catheter and an unexpected situation such as no passage through twisted blood vessels are avoided so that a burden on the patient can be reduced, the treatment can be completed within a short time, and cost reduction can be achieved by reducing the number of catheter to be used.

Apparatuses (including devices, kits, and systems) and methods to non-invasively and chemically (rather than thermally) activate thermoreceptors to modulate sleep. For example, described herein are apparatuses including topical compositions that stimulate thermoreceptors on the subject's skin (e.g., forehead, hands, and/or feet) for a period of time to induce a sensation of temperature (heat or cold) without significantly altering the person's actual skin temperature to improve sleep quality, including reducing sleep-onset latency, enhancing depth of sleep, and/or extending the amount of time a subject sleeps. The subject may be suffering from insomnia or some other sleep disorder.

A method of providing and/or injecting octreotide acetate to a subject in need thereof includes storing the octreotide acetate in a cartridge of a multi-use multi-dose injector provided with a variable dose setter and actuator. The injector includes a needle configured for subcutaneous administration of the octreotide acetate, the octreotide acetate having a concentration of 2,500 μg/mL. The method further includes providing, on the injector, a plurality of indicia only at prescribed doses of 50 μg, 100 μg, 150 μg and 200 μg settable via the dose setter without indicia between said prescribed doses; and permitting setting of a dose of the octreotide acetate by rotation of the variable dose setter, wherein the injector is configured to provide at least one audible feedback during the rotation.

Apparatus and methods are provided for applying negative pressure to tissues of a patient that are transmitted to the vertebral venous system of the patient and thereby lowering intracranial pressure. Intracranial pressure is thus lowered easily without increasing the work of breathing, without needing to be intubated, and without breathing through a valve in patients with elevated increased intracranial pressure.

Systems and methods for reducing pathogens near an implant are discussed. In some cases, the methods include reducing contaminants in a portion of a patient that has an implant and that is disposed interior to a closed surface of skin of the patient. The method can further include placing a conduit in the closed surface of skin and flowing an antimicrobial fluid into that portion of the patient to contact the antimicrobial fluid with a surface of the implant and tissue adjacent to the implant. In some cases, the antimicrobial fluid is then removed from the portion of the patient having the implant. As part of this method, biofilm near the implant can be mechanically, ultrasonically, electrically, chemically, enzymatically, or otherwise disrupted. Other implementations are described.

Devices and methods for controlling intracompartmental pressure in muscle compartments and, potentially, reducing the incidence of compartment syndrome are disclosed. A device according the invention is a thin, elongate member with an outer layer. The device has a proximal end, which has a coupling constructed and adapted to connect with tubing, and a distal end. The outer layer is at least somewhat permeable to liquids and to cells, either by way of perforations along its length or because of its natural properties. Within and encased by the outer layer lies a core, also porous, and typically an open-celled foam. The core is compressible under the range of suction pressures typically applied in medical contexts. A guide wire may initially be present in the device to aid in its placement. Methods for making such devices, especially on an ad hoc basis, are also disclosed.

A baby monitor system comprises: a memory; and a processor coupled to the memory and configured to: obtain a sleep schedule of a baby; obtain vitals of the baby, wherein the vitals are based on pulse oximetry, Doppler monitoring, or temperature sensing; and cause a first sound or a first light to emit in response to the sleep schedule and the vitals. A method comprises: obtaining a sleep schedule of a baby; obtaining vitals of the baby, wherein the vitals are based on pulse oximetry; and causing a first sound or a first light to emit in response to the sleep schedule and the vitals.

The present invention relates to an apparatus that provides therapeutic effects and a source of hydration. The apparatus includes a garment that has one or more compartments for storing a therapeutic element. The therapeutic element may include one or more herbs, essential oils, and combinations thereof. The apparatus also includes a portable drinking apparatus attached to the garment. The portable drinking apparatus includes a pouch having a liquid reservoir inserted therein and a drinking tube having a first end in fluid communication with the liquid reservoir and a second end having a mouth operated valve. Methods of use are also disclosed.