Devices, systems for localized delivery of a chemotherapy, hormonal therapy or targeted drug/biologic therapy to a target tissue area of an internal body organ of a patient. A catheter 10 forms a sealed treatment chamber in a natural lumen extending through the target tissue area. Air is purged from the chamber, which is then filled with a liquid drug solution for an adequate treatment session time, solution volume and drug concentration to saturate the target tissue area, thereby providing the treatment. The liquid drug solution may be circulated or recirculated through the chamber or maintained stationary therewithin. The drug may saturate the target tissue area and pass therethrough into the lymphatic system or interstitial space, which may serve as a reservoir of the drug for continued therapeutic treatment after withdrawal of the catheter. The chamber is evacuated at the end of the treatment session.

A fully implantable intracorporeal blood purifier for patients with impaired, missing, or normal kidneys overwhelmed by a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia, primary myelofibrosis, or chronic myelogenous leukemia. Functioning continuously or intermittently around the clock, the patient is spared the need to visit the clinic as frequently for treatment, and less severe renal dysfunction may allow the intervals between visits to be considerably extended if not eliminated. The intracorporeal blood purifier represents the extractive or negative component in a prosthetic disorder response system of which the positive component detects the need for and releases medication such as tyrosine-kinase inhibitorsimatinib, and interferon alfa-2b, and cooperates with the purifier to accomplish kidney functions not simply extractive, such as releasing hormones, calcitriol, sodium, and potassium into the blood, maintaining electrolyte, acid-base, and fluid balance, and furnishing small molecule amino acids and glucose by directly targeting the gut.

Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

An apparatus for performing a balloon dilation procedure at the site of a stenosis or for deploying a stent in a patient, the apparatus including a single lumen catheter having a proximal end and a distal end, and a high pressure balloon attached to the distal end of the catheter. The high pressure balloon is fabricated from a semi-compliant material that has an average rated burst pressure of between about 15 and about 27 atmospheres of pressure and exhibits a dumbbell-shaped outer periphery when inflated to a first atmospheric pressure and a substantially linear outer periphery when inflated to a second atmospheric pressure.

Disclosed is a method including establishing a first communication link between a surgical visualization system outside a sterile field in an operating room and a primary display inside the sterile field, transmitting an image frame from the surgical visualization system to the primary display, establishing a second communication link between a surgical robotic hub in the operating room and the primary display, and transmitting another image frame from the surgical robotic hub to the primary display.

A device, a process and a computer program, pertaining to a determination of situations during breathing or during a ventilation are described. Concepts for obtaining, detecting or determining information are described. The information, for example, is information concerning the respiratory muscles of the patient, concerning a load-bearing capacity of a patient, concerning a need for breathing assistance and also concerning the possibilities of adequately assisting the breathing by stimulation are very valuable in the treatment and therapy of living beings or patients.

A method and device for forming a sensor, the method including winding a desired length of wire from a first spool to a second spool, transferring the second spool to a spindle mounted in axial alignment with a substrate, securing the wire to a substrate, rotating the substrate about its axis such that the wire is drawn from the first spool to form a wound region, transferring the second spool to a twist former on which the first spool is mounted, and rotating the first spool and the second spool relative to each other to form a twist pair from the wire.

A dilation assembly includes a shaft and a dilator coupled with the distal end of the shaft. The dilator includes a proximal end, a distal end, and a center portion positioned between the proximal end and the distal end. The center portion dilates from a first configuration to a second configuration. The center portion has a larger diameter than the proximal end and the distal end when the center portion is in the second configuration. At least one gripping feature is positioned on at least a portion of the exterior surface of the center portion. The gripping feature provides friction between the center portion and a bodily lumen when the center portion is in the second configuration.

A method of managing a medical suction device through a network may be embodied by the management server through the steps of: storing operation information of at least one medical suction device in a storage unit provided in the management server, generating an operation start determination reference value of the medical suction device based on the operation information, receiving information on conditions of a patient from a medical suction device installed at an outside, and determining whether to start an operation of the medical suction device that has transmitted the information on conditions of the patient based on the operation start determination reference value and the information on conditions of the patient.

There is provided system for monitoring spontaneous breathing of a mechanically ventilated target individual, comprising: a feeding tube for insertion into a distal end of an esophagus of the individual, sensor(s) disposed on the feeding tube at a location such that the sensor(s) is located at the distal end of the esophagus of the individual when the feeding tube is in use, wherein the sensor(s) is positioned for sensing values by contact with the tissue of the esophagus including a lower esophageal sphincter (LES) and/or tissue in proximity to the LES, and code for computing an indication of a frequency band of diaphragm movement of the individual according to an analysis of values sensed by the sensor(s), and for adjustment of parameter(s) of a mechanical ventilator for mechanically ventilating the individual, wherein the instructions for adjustment are computed while the feeding tube is in use.