Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.

Devices and methods that provide minimally-invasive approaches to performing treatments on soft tissue, such as that found in the bladder using various natural access paths such as transvaginal and transurethral. Treatments include the application of energy to nerves found in, under and around the trigone region of the bladder.

An intraluminal system for aspirating biological material from a lumen of a patient includes a disposable intraluminal device having a proximal portion and a distal portion. The system includes a disposable pump configured to aspirate the biological material from the lumen of the patient. The disposable pump is coupled to the proximal portion of the intraluminal device. The disposable pump comprises a pump chassis that houses: an inlet port configured to sealably attach to the proximal portion of the intraluminal device; an outlet port configured to expel the aspirated biological from the pump; and a flow controller configured to adjust a fluid flow through the pump, wherein the pump chassis is sized and shaped to be manually supported by a user.

Ureteral bypass devices and procedures for performing internalized urinary diversions within patients. Such a procedure includes implanting a first catheter and securing a distal end of the first catheter within the renal pelvis or ureter of a patient, implanting a cystostomy catheter through and securing a distal end of the cystostomy catheter within the urinary bladder of the patient, fluidically connecting proximal ends of the first and cystostomy catheters to an adapter, and then subcutaneously implanting a sampling/flushing port and fluidically connecting a proximal end of the sampling/flushing port to the adapter via a third catheter to yield an artificial ureteral bypass device, in which the first and cystostomy catheters are fluidically connected together and fluidically connected to the subcutaneously-placed sampling/flushing port.

An implantable device for treating hypervolemia includes an expandable chamber, a rigid chamber coupled to the expandable chamber, a first valve in fluid communication with both the expandable chamber and the rigid chamber, a second valve in fluid communication with the rigid chamber and an exterior of the implantable device, and an osmotic fluid. The expandable chamber includes a first semipermeable membrane. The rigid chamber includes a piston. The first valve has an open position to permit fluid flow between the expandable chamber and the rigid chamber. The second valve has an open position to permit fluid flow from the rigid chamber to the exterior of the implantable device. The osmotic fluid has a higher osmotic concentration than bodily fluid. The osmotic fluid is designed to absorb water from the bodily fluid through the first semipermeable membrane.

A ureteral catheter structure, comprising a catheter body (1). The catheter body (1) comprises a stepped braided tube (2), a bending tube (3), and a plastic catheter tip (14) which are spliced with each other. A first stainless steel outer tube (4) supports and connects the stepped braided tube (2) and the bending tube (3) at a splice therebetween, and a first PET heat-shrinkable film (5) is coated on the first stainless steel outer tube (4). A second stainless steel outer tube (6) supports and connects the bending tube (3) and the plastic catheter tip (14) at a position therebetween, and a second PET heat-shrinkable film (7) is coated on the second stainless steel outer tube (6). A traction wire (8) is provided within the catheter body (1), an end of the traction wire (8) being fixed on the bending tube (3), while the other end passing through the stepped braided tube (2). A heat-shrinkable sleeve (9) is provided outside the bending tube (3). An end of the ureteral catheter may be independently bent in multiple sections, thereby achieving a good detection effect, and solving the technical problem of instability when an end of the ureteral catheter is deflected.

Sensor electrodes are fabricated in situ within or on a surface of a medical device. For example, a catheter can have a lumen extending between first and second longitudinal ends of the catheter. A patterning mold can be inserted into the lumen via the first longitudinal end of the catheter such that first and second surface portions of the lumen are exposed from the patterning mold and remaining surface portions of the lumen are covered by and in contact with the patterning mold. A first electrode layer can be formed on the first and second surface portions exposed from the patterning mold using electroless deposition. After the forming, the patterning mold can be removed from the lumen. Additional electrode layers can be formed on the first electrode layer, for example, via electroplating. In some embodiments, the electrode layers can be used for detection of bacterial biofilm growth.

An apparatus for treating a urinary retention of a patient by discharging urine from a mammal urinary bladder through a mammal urethra. The apparatus comprises an expandable member adapted to be implanted inside the urinary bladder of the patient, a control device adapted to control the volume of the expandable member for emptying the mammal urinary bladder, and an implantable restriction devices adapted to close each ureter of a patient when discharging urine from the urinary bladder.

Devices, systems for localized delivery of a chemotherapy, hormonal therapy or targeted drug/biologic therapy to a target tissue area of an internal body organ of a patient. A catheter 10 forms a sealed treatment chamber in a natural lumen extending through the target tissue area. Air is purged from the chamber, which is then filled with a liquid drug solution for an adequate treatment session time, solution volume and drug concentration to saturate the target tissue area, thereby providing the treatment. The liquid drug solution may be circulated or recirculated through the chamber or maintained stationary therewithin. The drug may saturate the target tissue area and pass therethrough into the lymphatic system or interstitial space, which may serve as a reservoir of the drug for continued therapeutic treatment after withdrawal of the catheter. The chamber is evacuated at the end of the treatment session.

A system for retrieving material from a cavity in a patient may include a tube having a proximal end and a distal end, the scope configured to be inserted into the cavity, and a filter assembly disposed between the tube and a vacuum source configured to apply negative pressure through the tube to cause the material to flow through the tube from the distal end to the proximal end, the filter assembly including a filter configured to trap the material in the filter assembly, and allow liquid and gases to pass through the filter assembly.