Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.

Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.

The present invention relates to a device for the administration of substances onto the epicardial surface of the heart. The device comprises a frame structure which is able to assume shaping, positioning, guiding and stabilizing functions. The frame structure may contain at least one sleeve. The device comprises a substance carrier which is able to accommodate the substance to be administered.

A pericardial drainage device for draining a fluid from the pericardium of a patient is provided. The drainage device comprises a conduit, said conduit comprising a first and second section. At least a portion of said first section is adapted to receive a fluid inside of said pericardium. The second section of said conduit is adapted to be positioned outside of the pericardium of a patient and enable the exhaust of said fluid received from said pericardium through at least a portion of said second section.

The present invention provides a novel design for sheaths intended for medical procedures. The sheath includes structures that anchor the sheath in a cavity or space when deployed but are at the same time retractable such that the sheath can be removed without tearing the tissue defining the space.

A safe, reliable, reproducible system and method for entry into the pericardial sac. The method and system described generally includes penetration of the subcutaneous tissue with a guide sheath or a relatively blunt stylet contained within a sheath. The stylet is removed from the sheath and a vacuum mechanism is installed. Once in contact with the pericardium, the sheath is engaged with the pericardial tissue, allowing the vacuum mechanism to draw the pericardium away from the heart to create a greater space between the heart and pericardium allowing needle insertion onto the pericardial cavity in a much safer and controlled manner.

Embodiments include methods for draining fluids from a body organ, such as pericardiocentesis. Embodiments include inserting a large diameter outer needle through the chest wall towards an organ, inserting a smaller diameter microneedle through the outer needle and into the organ, threading a microwire through the lumen of the inner microneedle into the organ, removing the outer needle and inner microneedle, threading a guide sheath over the microwire into the organ, removing the inner dilator and microwire from the guide sheath, inserting a stiffer guide wire through the guide sheath into the organ, removing the guide sheath, threading a drain sheath over the stiffer guide wire into the organ, removing the stiffer guide wire, securing the drain sheath to the patient using a stay fix device, and connecting a suction device to the proximal end of the drain sheath and creating negative pressure to facilitate fluid drainage.