A method may include producing, in a solution, microbubbles of nitric oxide having a targeted size; and directing the solution to a right side of a patient's heart, such that the microbubbles are directed to the patient's pulmonary arteries prior to being circulated through the patient's body. The solution may include saline or dextrose. Directing the solution to the right side of the patient's heart may include delivering the solution via a catheter, during a right-heart catheterization procedure. Directing the solution to the right side of the patient's heart may include injecting the solution into a median cubital vein of the patient. Directing the solution to the right side of the patient's heart comprises injecting the solution into an internal jugular vein, an external jugular vein or a femoral vein of the patient. The targeted size may correspond to a diameter of a specific branch of the patient's pulmonary arteries.

A system and method for delivering a therapeutic agent such as filler materials, biocompatible gels, and other substances through a catheter. The therapeutic agent can be a single component or multiple components that are delivered separately or mixed just prior to delivery or at the delivery site. The system and method use an automated delivery mechanism to maximize delivery of the therapeutic agent to the target tissue and minimize loss of the therapeutic agent within the catheter. The system and method are particularly useful for interventional approaches that deliver therapeutic agents to the wall of the heart.

A sensor implant device includes a shunt structure comprising a flow path conduit and a plurality of arms configured to secure the shunt structure to a tissue wall, and a pressure sensor device attached to one of the plurality of arms of the shunt structure. The pressure sensor device comprises one or more sensor elements, an antenna, control circuitry electrically coupled to the one or more sensor elements and the antenna, and a housing that houses the control circuitry.

A medical device comprises a catheter and an aspiration pump. The catheter has a hybrid reinforcement to improve performance characteristics. The aspiration pump is cycled to improve aspiration efficacy.

The invention relates to a method for determining a flow rate of a fluid flowing through an implanted vascular assist system (1), said method comprising the following steps: a) carrying out a first pulsed Doppler measurement at a first pulse repetition rate by means of an ultrasonic sensor (2) of the assist system (1); b) carrying out a second pulsed Doppler measurement at a second pulse repetition rate by means of the ultrasonic sensor (2) of the assist system (1), wherein the second pulse repetition rate differs from the first pulse repetition rate; c) determining the flow rate using measurement results of the first pulsed Doppler measurement and the second pulsed Doppler measurement.

A snare-integrated myocardial electrical signal-detecting catheter is proposed. The snare-integrated myocardial electrical signal-detecting catheter enables a cerclage wire to pass through the His bundle by way of detecting an electrical signal from the myocardium, and safely guides the cerclage wire into a patient's body by capturing the cerclage wire, which has passed through the His bundle, with a snare built in the catheter. The snare-integrated myocardial electrical signal-detecting catheter includes: a catheter having a hollow space to insert a guidewire thereinto, and having a distal part thereof coupled to at least one or more electrodes to detect an electrical signal of the myocardium; a snare lumen built along a longitudinal direction in a sidewall of the catheter, and having a hollow space therein; and a snare inserted into the snare lumen and having one end thereof provided with at least one or more annular wires.

A system configured to cut leaflet tissue at a cardiac valve may comprise a guide catheter and a cutting mechanism routable through the guide catheter. The cutting mechanism includes a cutting arm and a plurality of grasping arms rotatably coupled to the cutting arm. The grasping arms are connected to the cutting arm via a central hinge and are actuatable between a closed position against the cutting arm and an open position where the grasping arms extend laterally away from the cutting arm by rotating about the hinge. Targeted cardiac leaflet tissue may be grasped between the cutting arm and the grasping arms and cut by a cutting element that is attached to or extends through the cutting arm.

A system configured to cut leaflet tissue at a cardiac valve may comprise a guide catheter having a proximal end and a distal end, wherein the distal end of the guide catheter is steerable to a position above a cardiac valve. The system may also include a hook catheter having a proximal end and a distal end, the hook catheter configured to extend from the distal end of the guide catheter through a first orifice of the cardiac valve. Further, the system may comprise a cutting mechanism extending from the hook catheter, the cutting mechanism configured to cut a portion of leaflet tissue of the cardiac valve. Finally, the system may include a handle coupled to the proximal end of the guide catheter, the handle comprising at least one control operatively connected to the cutting mechanism.

A medicine injection catheter includes: a catheter main body formed with a medicine supply lumen; a tubular body connected to the distal end of the catheter main body and having a lumen communicating with the medicine supply lumen; an injection needle connected to the tubular body; a tubular cover member that accommodates the tubular body and that is configured to be advanced and retracted in the axial direction of the catheter main body between a first position where a distal end of the injection needle is accommodated in the tubular cover and a second position where the distal end of the injection needle protrudes forward from the inside space; a closing member to close and open the lumen of the tubular body, a motion conversion mechanism which converts advancing/retracting motion of the cover member into movement of the closing member to close the lumen of the tubular body.

Controllers and methods for heart treatments are disclosed herein. The controller can include a communication module that can send and receive data from heart therapy devices. The controller can include memory including stored instruction. The controller can include a processor. The processor can receive a signal of an impending electrical treatment at a processor. The processor can determine a current operating parameter of a blood pump communicatingly coupled with the processor. The processor can determine an adjustment to the operating parameter of the blood pump to affect an impedance of heart tissue to be affected by the impending electrical treatment. The processor can control the blood pump according to the adjustment to the operating parameter of the blood pump.