A ventricular assist device for a mammalian heart is disclosed that includes an aortic lumen member, the aortic member communicating with the interior of the aorta, an indwelling pump mechanism and a cardiac lumen member. The cardiac lumen member has at least one lumen tube that is connected to at least one intraventricular clamp that is connected to the inter chamber septum when the ventricular assist device is in the use position and is connected to at least one vertical septal clamp, the ventricular septal clamp is connected to the exterior facing myocardial tissue when the ventricular assist device is in the use position and at least a portion of the cardiac lumen tube extends through one of the cardiac chambers and a portion of the cardiac lumen extends from the ventricular septal clamp to the indwelling pump mechanism.

An injection device is described including a detection unit that includes an electrode that detects electrical characteristics of a biological tissue, a follow-up mechanism that follows motions of the biological tissue, and a puncture unit capable of puncturing the biological tissue. The injection device is configured to administer a predetermined substance to the biological tissue through a hollow portion defined in the puncture unit. A position of the puncture unit is specified based on a position of the electrode. The follow-up mechanism includes a spiral portion spirally extending around the puncture unit, and being stretchable and compressible along an extending direction of the puncture unit. Electrodes are disposed on an annular distal-end projected plane of the spiral portion, as seen from a distal end side of the puncture unit, along a circumferential direction of the puncture unit.

A venous drainage cannula, catheter, or other device is in certain embodiments convertible or adjustable for application in cardiac surgery procedures involving cardiopulmonary bypass. Such a convertible cannula device can be modified, for example, for use as both a multi-stage cannula and a bi-caval cannula, so that the same device can be used in multiple different procedures where one or the other cannula type is needed. Such convertible cannula or other device can simplify and reduce a number of parts needed for a bypass procedure, by providing one adjustable and versatile device to serve multiple functions where different cannulae are traditionally required. Various embodiments further provide cannula devices where a variety of different hole or opening arrangements and configurations can be achieved, to adapt to various different procedures.

Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.

A medical device comprises a catheter and an aspiration pump. The catheter has a hybrid reinforcement to improve performance characteristics. The aspiration pump is cycled to improve aspiration efficacy.

The present disclosure provides unique products and methods for accessing the vasculature of a patient. The catheter arrangements disclosed herein include a distal segment having a first substantially straight portion, a laterally extending portion, a tip-opposing portion, a tip-deflecting portion and a distal tip. The first substantially straight portion has a longitudinal axis that extends between the tip-opposing portion and the distal tip. The tip-deflecting portion extends transverse to and passes or crosses through the longitudinal axis and deflectably supports the distal tip such that the distal tip can deflect towards the tip-opposing portion upon an external force.

A ventricular assist device includes a stent for placement within a cardiac artery and arranged for placement, the stent arranged to have an open configuration defining a flow path, a rotor sized to fit within the stent and arranged for percutaneous placement the flow path, the rotor including a surface disposed about a central portion and angled with respect to the flow path and having a first plurality of magnets. A collar is sized for placement about the cardiac artery and includes a stator. A power source is coupled to the stator, and the stator and the rotor are arranged to rotate the rotor about an axis. A timing control module controls a rotational speed of the rotor. Accordingly, the surface of the rotor is arranged to move blood along the flow path in response to rotation of the rotor.

Described herein are devices, methods and kits for assessing and/or enhancing the accessibility of a subvalvular space of a heart, accessing the subvalvular space of the heart (e.g., to provide access for one or more other devices), and/or positioning one or more devices in the subvalvular space of the heart. The devices described herein may, for example, comprise catheters that may be used to manipulate one or more chordae tendineae, diagnostic catheters having different sizes and/or shapes (e.g., different curvatures), guide catheters having different sizes and/or shapes (e.g., different curvatures), and visualization catheters. In some variations, the devices, methods, and/or kits may be used to visualize a target site, such as a subannular groove of a heart valve. In certain variations, the devices, methods, and/or kits may be used to manipulate chordae tendineae to provide additional space in a ventricle of a heart (e.g., enhancing the accessibility of the ventricle).

Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.