Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.

A system and method for controlling a pump in a drilling system, of which the method includes determining a plurality of baseline behaviors for one or more valves of the pump, determining a plurality of in-use behaviors for the one or more valves of the pump. Each of the plurality of in-use behaviors are determined based on one or more measurements from one or more sensors. The method also includes comparing the in-use behaviors and the baseline behaviors, and forecasting, based on the comparison of the in-use behaviors and the baseline behaviors, a remaining useful life of the at least one of the one or more valves.

A system and method for controlling a pump in a drilling system, of which the method includes determining a plurality of baseline behaviors for one or more valves of the pump, determining a plurality of in-use behaviors for the one or more valves of the pump. Each of the plurality of in-use behaviors are determined based on one or more measurements from one or more sensors. The method also includes comparing the in-use behaviors and the baseline behaviors, and forecasting, based on the comparison of the in-use behaviors and the baseline behaviors, a remaining useful life of the at least one of the one or more valves.

There is described a patch pump comprising a cartridge, a power source, a pump system, a drug delivery device and a control system configured to operate in particular the pump system and the drug delivery device. The pump system comprises, on the one hand, a pump having a pump housing containing a pump piston and a valve piston and, on the other hand, a pump drive comprising a piston motor and a valve motor for driving the pump piston and the valve piston independently from each other through a first and a second transmission. The drug delivery device comprises a transdermal delivery system having a needle actuation mechanism configured for transdermal insertion of a cannula.

A pump draws fluid from a reservoir and drives the fluid downstream to a spray tip where the fluid is applied to a surface. A piston is driven in a reciprocating manner to pump the fluid. A check valve is disposed downstream of the piston to regulate a flow of the fluid downstream from the piston. The pump is initially dry and is primed with fluid prior to operation. To facilitate priming, the piston is dimensioned to impact the ball and unseat a valve member of the check valve during a priming stroke, thereby ejecting any air from the pump through the check valve. With the air ejected from the pump, a vacuum is formed during a suction stroke of the piston, which draws fluid downstream from the reservoir to prime the pump.

A pump draws fluid from a reservoir and drives the fluid downstream to a spray tip where the fluid is applied to a surface. A piston is driven in a reciprocating manner to pump the fluid. A check valve is disposed downstream of the piston to regulate a flow of the fluid downstream from the piston. The pump is initially dry and is primed with fluid prior to operation. To facilitate priming, the piston is dimensioned to impact the ball and unseat a valve member of the check valve during a priming stroke, thereby ejecting any air from the pump through the check valve. With the air ejected from the pump, a vacuum is formed during a suction stroke of the piston, which draws fluid downstream from the reservoir to prime the pump.

In order to provide a system allowing an improved and facilitated preparation of a sample for an appropriate analysis, a device for preparing a patient's sample before analysis is provided. The device comprises a housing (10, 30) and an actuator (50). The housing includes a receiving chamber (32). The receiving chamber is configured for receiving a liquid. The actuator is movable relative to the housing. The actuator is configured for extracting a predetermined amount of the liquid received in the receiving chamber and for supplying the extracted liquid to a reagent chamber, so that the reagent is suspended in the liquid. The actuator comprises a metering chamber (52) configured for receiving the predetermined amount of the liquid and for supplying the predetermined amount of the liquid to the reagent chamber.

In order to provide a system allowing an improved and facilitated preparation of a sample for an appropriate analysis, a device for preparing a patient's sample before analysis is provided. The device comprises a housing (10, 30) and an actuator (50). The housing includes a receiving chamber (32). The receiving chamber is configured for receiving a liquid. The actuator is movable relative to the housing. The actuator is configured for extracting a predetermined amount of the liquid received in the receiving chamber and for supplying the extracted liquid to a reagent chamber, so that the reagent is suspended in the liquid. The actuator comprises a metering chamber (52) configured for receiving the predetermined amount of the liquid and for supplying the predetermined amount of the liquid to the reagent chamber.

A pump includes a pair of valves, coupled to a camshaft that selectively opens and closes the valves such that when one valve opens the other valve closes. The valves are in fluid communication with a piston chamber. A crankshaft operates a piston in a piston cylinder with the opening and closing of the valves such that as the piston is drawn from the piston chamber, the inlet valve is open and the outlet valve is closed and when the piston is forced into the chamber, the outlet valve is open and the inlet valve is closed. The camshaft and crankshaft are coupled together to cause synchronous operation of the valves and piston.

A pump includes a pair of valves, coupled to a camshaft that selectively opens and closes the valves such that when one valve opens the other valve closes. The valves are in fluid communication with a piston chamber. A crankshaft operates a piston in a piston cylinder with the opening and closing of the valves such that as the piston is drawn from the piston chamber, the inlet valve is open and the outlet valve is closed and when the piston is forced into the chamber, the outlet valve is open and the inlet valve is closed. The camshaft and crankshaft are coupled together to cause synchronous operation of the valves and piston.