The disclosure relates to a method and a device for obtaining a breath sample of a test person, wherein the test person inhales a droplet mist which is preferably colder than the ambient temperature. The material exhaled and/or ejected by the test person is collected as a breath sample in one or more collection vessels.

A stand-alone chamber or multi-chamber inhalation system has at least two alternative vaporized test liquid supply systems for passive or self-administered delivery of vaporized test fluid and air to one or more test chambers, which can be passive or restraint chambers, based on operator selection of delivery on and off times in a passive mode or actuation of an actuator in the chamber by a test animal in a self-administered mode. In one case, a multiple inhalation chamber system has two or more separate test fluid delivery systems and provides options for selective passive uniform drug delivery to multiple chambers or selective delivery of two or more different drugs to different groups of chambers from different delivery systems so that two different drugs or different concentrations of delivered drugs can be tested simultaneously.

A method for controlling the delivery of a breathing gas to a patient. The method comprises: delivering a flow of breathing gas to a patient, the breathing gas having a breathing gas flowrate and a fraction of inspired oxygen; measuring an oxygen saturation level of the patient; determining a respiratory rate of the patient; automatically adjusting the fraction of inspired oxygen of the breathing gas based on the measured oxygen saturation level of the patient and a breathing gas flowrate set-point; and automatically adjusting the breathing gas flowrate set-point based on the determined respiratory rate of the patient.

A method of aspiration detection and intubation placement verification for an endotracheal tube comprises: Attempting to intubate the patient with an endotracheal tube; Providing a multimodal aspiration detection and intubation placement verification system for an endotracheal tube having a housing and sensors within the housing, wherein the sensors include at least i) a sensor for a first gastric acid, and ii) a sensor for a second gastric acid different from the first gastric acid; Coupling the housing to the endotracheal tube whereby patient exhalation can flow through an internal passage of the housing, wherein the sensors within the housing come into contact with the patient exhalation; and Utilizing the sensor output for at least one of Detecting aspiration and to verification of intubation placement. The sensors include an electric chemical sensor array which can detect odor molecules at concentrations of less than 10 parts per billion in the gas phase.

Nebulizer systems, adapters, methods, and apparatuses are described for a nebulizer adapter that includes a body, an inlet for aerosolized respiratory medications and/or medical marijuana and/or other pharmaceuticals, a breathing gas inlet tube and outlet tube, a barrier or body, and a drain lumen port that passes from the bottom of the barrier or body of the apparatus to the exterior into a port drain. The port drain would be in fluid communication with a receptacle removably attached to the annular lid that is attached to the bottom of the adapter body for collecting condensed moisture, wherein the receptacle comprise an actuator member configured to actuate the airtight seal of the annular lid upon attachment. The adapter includes a sensory system and temperature regulating system that continuously detects and regulates the temperature within an adapter to minimize condensates from forming and interfering with patient care. A computation device also stores individual patient outcomes and corresponding sensory information and accesses stored aggregate individual patient outcomes and corresponding sensory information from other sensory systems, wherein a machine learning algorithm utilizing quantum computing compares current individual patient sensory information, stored aggregate patient outcomes, and corresponding sensory information from other sensory systems to automatically predict statistical likelihoods of patient outcomes and automatically generate possible treatments and suggested diagnosis, wherein said display screen can access and display said statistical likelihoods of similar patient outcomes and automatically generated possible treatments and suggested diagnosis. An optional drainage system suctions condensate into a drainage port using mechanical energy produced by the internal force of a spring. There is a display screen where hospital workers and telemetry units can access the sensory information, alert notifications to hospital personnel, and manually override if necessary.

Methods and systems for targeting, accessing and diagnosing diseased lung compartments are disclosed. The method comprises introducing a diagnostic catheter with an occluding member at its distal end into a lung segment via an assisted ventilation device; inflating the occluding member to isolate the lung segment; and performing a diagnostic procedure with the catheter while the patient is ventilated. The proximal end of the diagnostic catheter is configured to be attached to a console. The method may also comprise introducing the diagnostic catheter into the lung segment; inflating the occluding member to isolate the lung segment; and monitoring blood oxygen saturation. The method may further comprise introducing the diagnostic catheter into the lung segment; determining tidal flow volume in the lung segment; determining total lung capacity of the patient; and determining a flow rank value based on the tidal flow volume of the lung segment and the total lung capacity.

An attachment device for a sample collection device for obtaining samples from exhaled respiratory air includes an inlet tube, a dip tube for discharging the respiratory air from the sample collection device, and at least a portion of a spiral path. The portion runs into an outlet opening which is designed to conduct the respiratory air to the sample collection device.

The present disclosure pertains to a system and method for monitoring lung disease in a patient that is based on information that is derivable from home therapy devices including a ventilation therapy device and an oxygen saturation monitor such as a pulse oximeter. The measured parameters are used to model shunt fraction and a volume of dead space. Based on changes in gas exchange and results of a nitrogen washout test, a change in gas exchange impairment in the patient is observed and is then used to determine progression of a disease, identify a cause of the impairment, and/or to guide treatment of the patient.

A system includes a control unit configured to be worn by a subject, and having a wireless transceiver configured to receive and transmit signals and a processor coupled to a memory, at least one respiratory volume sensor mountable to the chest or abdomen of the subject and at least one secondary sensor mountable relative to the subject. The respiratory volume sensor is configured to operably generate one or more volumetric signals representative of a respiratory volume of the subject and communicate the one or more volumetric signals to the wireless transceiver of the control unit. The at least one secondary sensor is configured to operably generate one or more secondary signals and representative of at least one of a physiological, a cardiopulmonary or a metabolic condition of the subject, and communicate the one or more secondary signals to the wireless transceiver of the control unit.

A stand-alone chamber or multi-chamber inhalation system has at least two alternative vaporized test liquid supply systems for passive or self-administered delivery of vaporized test fluid and air to one or more test chambers, which can be passive or restraint chambers, based on operator selection of delivery on and off times in a passive mode or actuation of an actuator in the chamber by a test animal in a self-administered mode. In one case, a multiple inhalation chamber system has two or more separate test fluid delivery systems and provides options for selective passive uniform drug delivery to multiple chambers or selective delivery of two or more different drugs to different groups of chambers from different delivery systems so that two different drugs or different concentrations of delivered drugs can be tested simultaneously.