The present invention improves control of currents in a multi-site direct current neurostimulation system. Precise control incorporates three constant current sources in a system consisting of spinal, polarizing and peripheral circuits. Constant current sources (sinks) are placed on the high side of the peripheral circuit and one sink in series on the low side of the spinal circuit in a four electrode configuration, for maintaining both predetermined currents, and current ratios, as the electrode/skin impedance and body impedance vary over the course of a treatment. Resistive steering is also implemented.

The present invention improves control of currents in a multi-site direct current neurostimulation system. Precise control incorporates three constant current sources in a system consisting of spinal, polarizing and peripheral circuits. Constant current sources (sinks) are placed on the high side of the peripheral circuit and one sink in series on the low side of the spinal circuit in a four electrode configuration, for maintaining both predetermined currents, and current ratios, as the electrode/skin impedance and body impedance vary over the course of a treatment. Resistive steering is also implemented.

A power supply unit for a direct-current galvanic electrolysis device has a housing configured to be held in a hand of a patient and having a conductive outer surface forming a first electrode that is adapted to make electrical contact with the hand of the patient while the housing is being held. In addition, the power supply unit has an electrical power source, an electrical connector supported for detachably coupling to a second electrode in the form of a needle handpiece, a regulating circuit coupled to the power source and having positive and negative output nodes. The regulating circuit positive output node is electrically coupled to the first electrode and the negative output node is electrically coupled to the connector and thereby, in use, to the second electrode of the needle handpiece.

A power supply unit for a direct-current galvanic electrolysis device has a housing configured to be held in a hand of a patient and having a conductive outer surface forming a first electrode that is adapted to make electrical contact with the hand of the patient while the housing is being held. In addition, the power supply unit has an electrical power source, an electrical connector supported for detachably coupling to a second electrode in the form of a needle handpiece, a regulating circuit coupled to the power source and having positive and negative output nodes. The regulating circuit positive output node is electrically coupled to the first electrode and the negative output node is electrically coupled to the connector and thereby, in use, to the second electrode of the needle handpiece.

Bacteria, cancer cells, fungus and other harmful cells located beneath the surface of a mammal body can be effectively destroyed by passing an electrical current through the area to be treated. Electrodes are positioned on either side of the area to be treated, for example, gums, fingers, arms, legs, feet and torso, and an electric current is caused to flow between the electrodes and through the area to be treated. The electric current will destroy the bacteria, cancer cells, fungus or other harmful cells.

Stimulation using EA of LI-4, LI-11, GV-14 and GV-20 in humans, horses, and rodents results in mobilization of MSCs into systemic circulation. Methods are provided for increasing mesenchymal stem cells in the circulating blood of a mammal by contacting acupuncture points LI-4, LI-11, GV-14, and GV-20 of the mammal with a therapeutically effective amount of EA stimulation to mobilize MSCs into the circulating blood of the mammal. Methods for treating damaged tissue, specifically damaged tendons are also provided. Isolated mesenchymal stem cells made according to these methods, methods of isolated them, and stem cell banks that store them are also provided.

Stimulation using EA of LI-4, LI-11, GV-14 and GV-20 in humans, horses, and rodents results in mobilization of MSCs into systemic circulation. Methods are provided for increasing mesenchymal stem cells in the circulating blood of a mammal by contacting acupuncture points LI-4, LI-11, GV-14, and GV-20 of the mammal with a therapeutically effective amount of EA stimulation to mobilize MSCs into the circulating blood of the mammal. Methods for treating damaged tissue, specifically damaged tendons are also provided. Isolated mesenchymal stem cells made according to these methods, methods of isolated them, and stem cell banks that store them are also provided.

Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

There is provided a neural interface device for unidirectional stimulation of a nerve including at least one A-type nerve fiber or at least one at least partially myelinated nerve fiber. The device includes an electrode arrangement for placing on or around the nerve. The electrode arrangement includes a first electrode configured to be positively charged and a second electrode configured to be negatively charged, where the surface area of the second electrode is larger than the surface area of first electrode.

A biogalvanic battery therapeutic appliance that can effectively pass electric current even at a negative electrode with an extended length and a high resistance value, achieving excellent current stimulation effect with comfortable touch, is configured such that a negative electrode component and a positive electrode component are connected to a conductive member and are brought into contact with a skin forming an energized circuit in the skin. The conductive member connects the negative electrode component and the positive electrode component between a surface of the negative electrode component and a surface of the positive electrode component on the opposite side from a skin contact surface. The conductive member and the positive electrode component are both made of the same carbon material.