Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition. The methods can include intravascularly positioning a neuromodulation catheter within a blood vessel proximate to neural fibers innervating an immune system organ of the patient. The method also includes reducing sympathetic neural activity in the patient by delivering energy to the neural fibers innervating the immune system organ via the neuromodulation catheter. Reducing sympathetic neural activity improves a measurable physiological parameter corresponding to the immune system condition of the patient.

A quantum wave therapy apparatus includes a quantum wave generator and a quantum wave irradiator. The quantum wave irradiator includes an oscillation plate, and a resin panel that is formed by kneading semiconductor powder, which reflects quantum waves, into resin. The quantum wave generator includes an AC adaptor, and a coil that is connected in series to the negative electrode side of an output smoothing capacitor in the AC adaptor, and that constitutes a serial resonance circuit. An electromotive voltage induced in the serial resonance circuit by extraneous electromagnetic waves is superimposed on a negative potential output from the AC adaptor, and a resulting voltage is applied to the oscillation plate, whereby quantum waves are generated. The quantum waves are applied to a diseased portion. The quantum waves reflected from surroundings are reflected again by the semiconductor powder in the resin panel and are applied to the diseased portion repeatedly.

The present invention relates to a visualization apparatus (1) comprising a signal processor (2) for processing measurement signals from an ultrasound measurement (3) and a rendering device (4) coupled to a processor for rendering a representation for discerning a region of tissue with changed property (42) upon energy application to the tissue from a region with unchanged property (41) within two extremities (44,47) of the representation indicative of two boundaries defining the tissue thickness. The rendering of the tissue with changed property (42) and the tissue with unchanged property (41) with different visual aspects is readily absorbable by a person who applies energy to the tissue.

Embodiments provide for systems and methods for modulating activity of a live neuronal circuit within the brain of a mammal. In one example, a method comprises applying a focused microwave pulse to a focal spot corresponding to the live neuronal circuit, while simultaneously monitoring a brain image produced by a brain imaging system. In this way, the focused microwave pulse may be used to transiently modulate the function of the live neuronal circuit, as guided by anatomical and functional information provided via the brain imaging system, useful for both research purposes and for treating psychiatric, neurological and neuroendocrine disorders.

Embodiments provide for systems and methods for modulating activity of a live neuronal circuit within the brain of a mammal. In one example, a method comprises applying a focused microwave pulse to a focal spot corresponding to the live neuronal circuit, while simultaneously monitoring a brain image produced by a brain imaging system. In this way, the focused microwave pulse may be used to transiently modulate the function of the live neuronal circuit, as guided by anatomical and functional information provided via the brain imaging system, useful for both research purposes and for treating psychiatric, neurological and neuroendocrine disorders.

A subcutaneous implant, including: (a) a circuitry unit having a first end, a second end, a conducting lateral side, and an opposing lateral side; (b) a first electrode, disposed on an outer surface of the circuitry unit and laterally circumscribing the circuitry unit at the first end; (c) a second electrode, disposed on the outer surface of the circuitry unit and laterally circumscribing the circuitry unit at the second end; (d) circuitry, disposed within the circuitry unit, and configured to be wirelessly powered to drive an electrical current between the electrodes; and (e) an insulating member, disposed on the opposing lateral side such that, on the opposing lateral side, each electrode is sandwiched between the insulating member and the circuitry unit, and the insulating member inhibits electrical conduction from the electrodes into the tissue. Other embodiments are also described.

A subcutaneous implant, including: (a) a circuitry unit having a first end, a second end, a conducting lateral side, and an opposing lateral side; (b) a first electrode, disposed on an outer surface of the circuitry unit and laterally circumscribing the circuitry unit at the first end; (c) a second electrode, disposed on the outer surface of the circuitry unit and laterally circumscribing the circuitry unit at the second end; (d) circuitry, disposed within the circuitry unit, and configured to be wirelessly powered to drive an electrical current between the electrodes; and (e) an insulating member, disposed on the opposing lateral side such that, on the opposing lateral side, each electrode is sandwiched between the insulating member and the circuitry unit, and the insulating member inhibits electrical conduction from the electrodes into the tissue. Other embodiments are also described.

Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. Each radioluminescent light source includes an interior chamber coated with phosphor material, such as zinc sulfide, and containing a radioisotope material, such as gaseous tritium. The volume, shape, phosphor material, and radioisotope material are selected for emission of light at a particular wavelength and delivering a particular irradiance on the retina (when implanted in an eyeball). The wavelength is in the range of 400 to 600 nm and the irradiance is substantially 10.sup.9 to 10.sup.11 photons per second per cm.sup.2.

This invention provides block copolymer (BCP) encapsulated nanoparticles. The BCP-encapsulated nanoparticles are used in methods for targeting a tumor, in methods of imaging a tumor and in methods of treating cancer including hyperthermia of tumors. This invention further provides processes for preparation of BCP-encapsulated nanoparticles.

This invention provides block copolymer (BCP) encapsulated nanoparticles. The BCP-encapsulated nanoparticles are used in methods for targeting a tumor, in methods of imaging a tumor and in methods of treating cancer including hyperthermia of tumors. This invention further provides processes for preparation of BCP-encapsulated nanoparticles.