A method for optogenetics experiments, based on wavefront shaping and including: calculating the transmission matrix between an input end and an output end of the multimode fiber under a fixed shape; implanting the output end into an intracranial space of an experimental subject; and performing wavefront compensation to a light to be input into the input end, according to the spatial position of the optical stimulation and the transmission matrix of the multimode fiber, to form a compensated expanded light, and inputting the compensated expanded light from the input end into the multimode fiber, such that the compensated expanded light, after being transmitted by the multimode fiber to the output end and output from the output end, is capable of focusing at the spatial position of the optical stimulation.

A balloon catheter (1) comprising: a first shaft (10) having a first lumen (11) and a second lumen (12); a second shaft (20) located distal to the first shaft (10); a balloon (30) located distal to the second shaft (20); and an optical fiber (40) disposed inside the balloon (30); wherein: the first shaft (10) is made of a resin; a cross-sectional area of the resin forming the first shaft (10) is larger than a cross-sectional area of either the first lumen (11) or the second lumen (12), which has a larger cross-sectional area, in a cross section perpendicular to a longitudinal direction; the optical fiber (40) is joined to a distal end (11d) of the first lumen (11); a proximal end (30p) of the balloon (30) is joined to the second shaft (20); and a distal end (30d) of the balloon (30) is joined to the optical fiber (40).

An ingestible gastrointestinal phototherapy device has a spherocylindrical body of non-digestible material having a cylindrical midsection and transparent light portals at ends thereof. The cylindrical midsection has control circuitry and a power source therein and each light portal is transparent and comprises an array of bioactive light source elements therein emitting bioactive light therefrom and being operably coupled to the control circuitry and power source.

A photobiomodulation system includes a) a control module having electronic subassembly disposed in a housing, a connector coupled to the housing and defining a connector lumen, and at least one light source to produce light in response to signals from the electronic subassembly; b) a lead coupled or coupleable to the control module and having a lead body defining a lead lumen and at least one opening along a distal portion of the lead, light emitters arranged along the distal portion of the lead, and optical fibers extending along the lead body and coupled to the light emitters; and c) a catheter assembly having a tube coupleable to a catheter pump, and a distal connector attached to the end of the tube and coupled or coupleable to the connector of the control module.

Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.

An implant system for photodynamic therapy with a light source for radiating light which is implantable in a resection cavity, and with an autonomous control unit which is connectable via a supply line to the light source.

A collagen cross-linking system for treating a tissue of a patient, the system including: a catheter having a flexible shaft and a conforming member, the flexible shaft having distal and proximal ends, a shaft body extending between the distal end and the proximal end, the shaft body defining a lumen, the conforming member being fixed to the catheter shaft near the distal end, the conforming member comprising a membrane defining a cavity in fluid communication with the lumen; a fluid source coupled to the proximal end of the catheter, the flexible shaft of the catheter being configured so that a flow of photosensitizing fluid provided by the fluid source flows through the membrane of the conforming member; and a light source coupled to the proximal end of the catheter, the catheter being configured so that photo-activating light generated by the light source passes through the membrane of the conforming member.

A light applicator (1) executes a transcutaneous photodynamic therapy (PDT), in tissue (25) of an organic body (23) and includes a needle section (5), extending longitudinally along an insertion axis (L), and at least one light-emitting element (7) at the distal end (3) of the needle section (5). An at least partially light-transparent applicator tip (9) extends at least distally from the at least one light-emitting element (7), for insertion of the needle section (5) into the tissue (25) of the organic body (23) along the insertion axis (L). A handgrip element (19) is arranged proximally with respect to the needle section (5) for manual positioning of the light applicator (1). The handgrip element (19) can be coupled to the needle section (5) for positioning and/or insertion, and is configured to be detachable from the needle section (5) for the execution of the PDT.

A system, for transcutaneous photodynamic therapy in an organ or organ segment of an organic body, includes a plurality of light applicators (9), a supply unit (23) and a placement template (39) placeable relative to the organic body for defined orientation of the light applicators. The light applicators include a needle-shaped insertion portion (15) for transcutaneous piercing along a piercing axis (E), a light-emitting applicator tip (19) at the distal end (13) of the insertion portion, and a fixing point (43) at a proximal distance d from the applicator tip. The placement template defines a plurality of fixing point receptacles (51) for fixing the light applicators with a defined fixing point and includes a first and second template parts (71, 75) defining first and second subsets (73, 77) of fixing point receptacles. The first template part is guidingly displaceable relative to the second template part along the piercing axis.

A system, for transcutaneous photodynamic therapy in an organ or organ segment of an organic body, includes a plurality of light applicators, a supply unit and a placement template placeable relative to the organic body for defined orientation of the light applicators. The light applicators include a needle-shaped insertion portion for transcutaneous piercing along a piercing axis, a light-emitting applicator tip at the distal end of the insertion portion, and a fixing point at a proximal distance from the applicator tip. The placement template defines fixing point receptacles for fixing the light applicators with a defined fixing point wherein the receptacles are arranged in accordance with a three-dimensional fixing point grid structure, that corresponds to a virtual organ-specific target point grid structure for the light-emitting applicator tips in the organ that is arranged parallel-displaced relative to the target point grid structure by the distance d along the piercing axis.