A bone implant includes a bore extending entirely through the bone implant. The bone implant also includes a light source to emit light onto bone adjacent the bone implant to stimulate bone growth and/or reduce bone loss.

System and methods for treating and shaping a keratin fiber are provided. A light-based system includes an activation system configured with one or more light source. The light source is configured to apply electromagnetic radiation at a target region including the keratin fiber. The light-based system applies the electromagnetic radiation to the target region to effectuate photocrosslinking with the assistance of a photosensitizer on the keratin fiber and transition the keratin fiber from a first physical state to a second physical state.

A light-based dental treatment system includes a handle generator having a generator housing and at least one light element configured to generate therapeutic light. The handle generator includes an alignment collet having a light passage extending along a movable interior collet profile. At least one delivery shaft assembly is selectively coupled with the handle generator. The at least one delivery shaft assembly includes a delivery shaft having proximal and distal shaft profile and a proximal light port. A distal light port of the delivery shaft is configured to deliver therapeutic light from the delivery shaft to a treatment location. The interior collet profile of the alignment collet is configured to grasp the delivery shaft and align the proximal light port with the at least one light element.

The present disclosure provides topical biophotonic materials and methods useful in phototherapy. In particular, the topical biophotonic materials of the present disclosure include a cohesive matrix, and at least one chromophore which can absorb and emit light from within the topical biophotonic material, wherein the topical biophotonic material is elastic. The topical biophotonic materials and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various other skin disorders.

A device includes light sources, electromagnetic field generators, and vibration components to apply a variety of treatment regimens to a living animal organism, including a human person or a body part of a person. The light and electromagnetic therapy are applied at frequencies which have physiological effects, and which can be combined to induce lipolysis, stimulate muscle, and achieve other effects. Feedback is used to dynamically adjust the intensity, duration, and other parameters of the light, electromagnetic, and vibration treatment modalities.

Bistable type II opsins are provided. Accordingly, there is provided a polypeptide comprising a bistable type II opsin and a heterologous ER export signal and/or membrane trafficking signal. Also provided are polynucleotides encoding same, cells expressing same and methods of use thereof.

A portable, personal therapy chamber for provision of radiation therapy. The therapy chamber includes a pair of telescopically positionable units that are lightweight and easily portable by a single user. The therapy chamber is configured for use by a single person lying generally prone on a surface. The units are formed from a plurality of pivotably coupled panels that are foldable in a first direction to a rolled up, tube-like storage configuration and unfoldable in a second direction to an arched formation or use configuration. The units, in the use configuration, are disposed to overlie the user and include a plurality of emitters that direct infrared energy toward the user's body.

The device for stimulating the Meibomian glands comprises a cap (2) and a plurality of light-emitting diodes (3) arranged on the inner surface of said cap (2). The light emitting diodes (3) are electrically connected to an external control and/or supply unit (4), provided with a control interface (6). The cap (2) comprises at least one matrix (30) of light-emitting diodes (3) arranged in areas of the inner surface of the cap (2) suitable for facing, in use, the eyelids and the periocular areas of the user.

Modulation of foreign body responses in living tissue, and more particularly, devices and related methods for light-based modulation of foreign body responses in living tissue are disclosed. Light sources are disclosed that provide light with characteristics for modulation of foreign body responses that may be elicited by percutaneous and/or subcutaneous devices, including medical devices and other consumer electronic devices. Light delivery structures are disclosed that propagate light from the light sources to irradiate associated subcutaneous tissues. Modulation of foreign body responses may include inhibiting collagen and fibrous tissue generation, modulating inflammation and healing, and/or increasing nitric oxide production and/or release. By modulating foreign body responses associated with percutaneous and/or subcutaneous devices, performance characteristics and lifetimes of such devices may be improved.

An ocular light therapy arrangement for treating a user having a neurologic disorder includes a light emitting device the emits a light having a flicker rate of less than or equal to about 2 Hz and/or greater than or equal to about 85,000 Hz at a wavelength of within a first range of from about 500 nm to about 565 nm, wherein the light is effective to reduce neurologic disorder symptoms by reducing stimulation of the user's retina and brain cortex.