The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (<50 kDa) protein or peptide or a small molecule that is conjugated to a phthalocyanine dye, such as IRDye 700DX.

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

The invention provides a laser system and method for administering multiple beams of laser energy in tissue treatment applications. The system administers the beams simultaneously in a distribution pattern of spatially separated overlapping and non-overlapping regions on a tissue. The simultaneous administration and distribution pattern permit the beams to propagate within a tissue without producing the light scattering effects that characterize the sequential application of multiple laser beams to a tissue.

A bone implant includes a rod having an aperture extending entirely through the rod. The aperture is to receive a fastener to couple the rod to a bone of a patient. The bone implant also includes a light source disposed on the rod. The light source is to emit light onto a portion of the bone adjacent the rod to at least one of stimulate bone growth or reduce bone loss.

A device combining laser technology with ozone and its use in a method to treat fungal infections is provided. The invention relates to a device to apply laser technology at different wavelengths in combination with ozone in a gaseous state. To do so it uses a plurality of laser emitters arranged in an electronic board, the light from which is radiated on a treatment chamber where a sealed bag containing the affected limb is introduced, and which is pumped with a pre-established concentration of ozone by means of an ozone generating system. The device is used as an effective method to treat fungal infections.

A light-emitting module includes a carrier, a plurality of light-emitting units, and a protection layer. The carrier has a lighting portion and an extending portion. The plurality of light-emitting units is disposed on the lighting portion. The protection layer covers the plurality of light-emitting units and the lighting portion, and exposes the extending portion.

The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (<50 kDa) protein or peptide or a small molecule that is conjugated to a phthalocyanine dye, such as IRDye 700DX.

A radiation device is for the radiation of human skin, preferably the face of a user, in particular at least with radiation in the red light range, with a source of radiation and a filtering device for filtering the radiation emitted by the source of radiation. The filtering device is configured in such a way that the radiation device emits radiation in a wavelength range from 280 to 400 nm and beyond that radiation in a wavelength range of 600 to 700 nm, and that the radiation device emits at least zonally radiation in a wavelength range of a visible color shade of the visible light spectrum and filters further radiation of the visible light spectrum.

A stimulation device includes an energy source; an electronics unit; an actuator that is coupled with the electronics unit and/or the energy source. The electronics unit includes a controller. The energy source, the electronics unit and the actuator are arranged in a housing. A fixing unit which is coupled with the housing and affixes the stimulation device on a heart or in a heart. The actuator emits electromagnetic waves for the stimulation of genetically manipulated tissue, and the controller controls the stimulation of the tissue by way of the electromagnetic waves of the actuator.

An implantable device for implantation in a human body or animal body. The device includes an energy source, an energy storage device, and an electronics unit. Further, an actuator is coupled with the energy storage device and it is configured to emit electromagnetic waves by discharging the energy storage device.