A pain relief device and method or system to aid in the resolution of pain in a body including at least one layer of PVDF film and at least one other layer for directional purposes, as well as a polarizing layer. The device can be packaged in various ways. Also described is a device that uses a combination of LED bulbs, polymer based materials and a near field accelerator to provide pain relief.

The invention relates to a device (17) for treatment of body tissue, in particular for the permanent occlusion of varicose veins, preferably in the lower limbs, of varicocele and/or of vascular malformations and/or for the use in aesthetic surgeries, preferably laser assisted lipolysis, and/or for tumor treatment by means of laser induced thermotherapy and/or photodynamic therapy, by means of a light diffuser (13) circumferentially and endoluminally irradiating said tissue by laser light energy, said diffuser (13) being connected at its proximal end to a source (10) of laser light energy via a flexible wave guide (12) comprising a fiber optic core (1) covered by an optical cladding (2) having a refractive index smaller than that of the core (1), wherein in the cladding (2) and/or in the core (1) imperfections (18) are provided, designed as recesses and adapted to direct the light, preferably to refract and/or reflect the light propagating within the core (1) and/or its optical cladding (2) in generally radial directions, wherein a cap (7) transparent to the laser light enclosing the distal end of the core (1) and its optical cladding (2) in a fluid tight and/or liquid tight manner is provided. According to the invention the device (17) is characterized in that the outer surface (19) of said optical cladding (2) is fused in the region (A) between said imperfections (18) to the inner surface (21), preferably the inner diameter, of the cap (7) and/or in that the outer surface (19) of said optical cladding (2) extending over a distance in front and/or behind the region (A) provided with the imperfections (18) is fused to the inner surface (21), preferably the inner diameter, of the cap (7).

The invention relates to a device (17) for treatment of body tissue, in particular for the permanent occlusion of varicose veins, preferably in the lower limbs, of varicocele and/or of vascular malformations and/or for the use in aesthetic surgeries, preferably laser assisted lipolysis, and/or for tumor treatment by means of laser induced thermotherapy and/or photodynamic therapy, by means of a light diffuser (13) circumferentially and endoluminally irradiating said tissue by laser light energy, said diffuser (13) being connected at its proximal end to a source (10) of laser light energy via a flexible wave guide (12) comprising a fiber optic core (1) covered by an optical cladding (2) having a refractive index smaller than that of the core (1), wherein in the cladding (2) and/or in the core (1) imperfections (18) are provided, designed as recesses and adapted to direct the light, preferably to refract and/or reflect the light propagating within the core (1) and/or its optical cladding (2) in generally radial directions, wherein a cap (7) transparent to the laser light enclosing the distal end of the core (1) and its optical cladding (2) in a fluid tight and/or liquid tight manner is provided. According to the invention the device (17) is characterized in that the outer surface (19) of said optical cladding (2) is fused in the region (A) between said imperfections (18) to the inner surface (21), preferably the inner diameter, of the cap (7) and/or in that the outer surface (19) of said optical cladding (2) extending over a distance in front and/or behind the region (A) provided with the imperfections (18) is fused to the inner surface (21), preferably the inner diameter, of the cap (7).

In one aspect, an example handheld device for providing a spectrochrome output includes (a) an enclosed chamber containing one or more substances; (b) a light source; (c) an electromagnetic coil; (d) one or more magnets; and (e) a housing, wherein the housing is configured to: (i) secure the enclosed chamber; (ii) secure the light source such that an output of the light source is substantially aligned to pass through the enclosed chamber in one or more directions; and (iii) secure the electromagnetic coil around the enclosed chamber such that an electromagnetic field is created in a substantially same direction of the output of the light source through the enclosed chamber.

The invention is method comprising the use of an external photic stimulator treat and/or prevent pain in a subject, such as migraine headache, dental pain, and/or other sources of cranial pain. The presently disclosed method includes treating the pain externally through the cheek, over the zygomatic arch and area of the trigeminal ganglion. The external photic stimulation is believed to inhibit excessive firing of trigeminal ganglion circuits, preventing the excessive expression of calcitonin gene-related peptides and/or other inflammatory manifestations of the pain.

A laser irradiation device for performing treatment on human skin includes a casing that includes a grip part and a barrel part; a laser oscillator that is accommodated in the casing and configured to generate a laser beam to be irradiated through the barrel part; a contact sensor unit that includes electrodes exposed at the end of the barrel part and a contact sensing unit configured to sense an electric current flowing through the electrodes; and a skin treatment unit that is detachably connected to the barrel part and is operated based on electric signals transmitted through the electrodes of the contact sensor unit.

A laser irradiation device for performing treatment on human skin includes a casing that includes a grip part and a barrel part; a laser oscillator that is accommodated in the casing and configured to generate a laser beam to be irradiated through the barrel part; a contact sensor unit that includes electrodes exposed at the end of the barrel part and a contact sensing unit configured to sense an electric current flowing through the electrodes; and a skin treatment unit that is detachably connected to the barrel part and is operated based on electric signals transmitted through the electrodes of the contact sensor unit.

Systems are provided for compact implantable multi-site optical stimulation and/or combined electrical and optical stimulation of spinal cord, brain, dorsal root ganglion, peripheral nerve, or other tissue. High-power LEDs or other light-emitting elements are provided at the site of stimulation, avoiding complex fiber optics or other means for coupling light from a distant laser along a stimulator to target tissue. Colocation of electrical stimulation contacts and light emitters allows the same tissue to be stimulated electrically and optically, at the same time or according to an alternating or other pattern of combined electrical and optical stimulation. These stimulators can be used as part of permanently implanted systems and/or as part of temporary, percutaneous stimulator systems. Optical and/or combined electrical and optical stimulation can be provided for pain relief, to encourage wound healing in nervous or non-nervous tissue, or to provide other clinical benefits.

A transcranial stimulator includes a main body formed in a shape that covers part or all of a head surrounding a skull, a light emission module configured in the main body to transmit light energy to a brain, and a controller configured to control an operation of the light emission module, wherein the light emission module includes a first optical device emitting light in a wavelength band of 630 nm to 680 nm toward the skull and a second optical device emitting light in a wavelength band of 780 nm to 990 nm toward the skull.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.