Methods of performing targeted alpha therapy of a cancer patient utilizing actinium-225, methods of preparing a targeted alpha therapy drug that includes actinium-225, methods of preparing actinium-225 from radium-226, and methods of recovering radium-226 from an aqueous produced material stream generated from a natural resource extraction process. The methods of recovering radium-226 include separating the radium-226 from the produced material stream to generate recovered radium-226. The methods of preparing actinium-225 include converting the recovered radium-226 into actinium-225. The methods of preparing the targeted alpha therapy drug include incorporating the actinium-225 into the targeted alpha therapy drug. The methods of performing targeted alpha therapy include treating the cancer patient with the targeted alpha therapy drug.

The present invention relates to a thermoplastic composition suitable for manufacturing a thermoplastic sheet for producing a medical cast, such as a radiation mask. The composition has a polymeric component comprising a mixture of a styrene acrylonitrile copolymer and polycaprolactone, optionally together with a cross-linker and/or a filler, wherein the polymeric component comprises, 20 to 40 weight % of a styrene acrylonitrile copolymer and 80 to 60 weight % of a polycaprolactone, expressed in weight % of the polymeric component, wherein the thermoplastic composition has a glass transition temperature of 35° C.-80° C. The invention further relates to a thermoplastic sheet and to a medical cast, in particular a radiation mask, obtainable from said composition. In a final aspect, the invention relates to a method for producing said sheet and said radiation mask.

A processing device (1) and method for determining a position and/or orientation for a multi-hole grid template in a medical interventional procedure is disclosed. An anatomical spatial information processing unit (2) receives and/or processes data representative of a target spatial volume in the body, and a grid position sampler (4) generates candidate positions of the grid template. A quality calculator (5) calculates, for each candidate, a quality metric indicating the suitability of the candidate position of the grid template for the interventional procedure. A position selector (6) selects the position and/or orientation from the candidates based on the quality metric. For each candidate, an spatial relationship between each grid hole trajectory and the target volume is determined, and the quality metric takes, at least, this spatial relationship into account.

A locator for the placement of a fiducial support device for brachytherapy may be used to perform a brachytherapy treatment in which one or more radioactive seeds are implanted into a treatment region of a patient.

Apparatus for planning a diffusing alpha-emitter radiation therapy (DaRT) treatment session. The apparatus includes an output interface and a memory configured with a plurality of tables which provide an accumulated measure of radiation over a specific time period, due to one or more types of DaRT radiotherapy sources which emit daughter radionuclides from the source, for a plurality of different distances and angles relative to the DaRT radiotherapy source. In addition, a processor is configured to receive a description of a layout of a plurality of DaRT radiotherapy sources in a tumor, to calculate a radiation dose distribution in the tumor responsive to the layout, using the tables in the memory, and to output feedback for the treatment responsive to the radiation dose distribution, through the output interface.

Disclosed is a bore based medical system comprising a camera carrier configured to be mounted in the bore based medical system and configured to monitor and/or track patient motion within said bore based medical system during radiotherapy, the bore based medical system comprising a rotatable ring-gantry configured to emit a radiotherapy beam focused at an iso-center of the bore based medical system, wherein the ring-gantry is configured to rotate at least partly around a through-going bore having a front side and a back side, configured to receive from said front side, a movable couch configured to be moved into and out from the through-going bore, wherein further the through-going bore comprises an inner side facing an inside of the bore, and wherein the camera carrier is configured to be mounted inside the bore in connection with the inner side of the through-going bore.

A process for treating highly localized carcinoma cells that provides precise positioning of a therapeutic source of highly ionizing but weakly penetrating radiation, which can be shaped so that it irradiates essentially only the volume of the tumor. The intensity and duration of the radiation produced by the source can be activated and deactivated by controlling the neutron flux generated by an array of electrically controlled neutron generators positioned outside the body being treated. The energy of the neutrons that interact with the source element can be adjusted to optimize the reaction rate of the ionized radiation production by utilizing neutron moderating material between the neutron generator array and the body. The source device may be left in place and reactivated as needed to ensure the tumor is eradicated without exposing the patient to any additional radiation between treatments. The source device may be removed once treatment is completed.

The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. The radiation detector is configured to provide real-time information indicative of ionizing radiation emitted by a radiation source. A controller may perform operations including receiving, from the radiation detector, real-time information indicative of at least one of: a particle flux rate, an energy fluence, or an absorbed dose of ionizing radiation emitted from the radiation source. The operations may also include determining, based on the received information, at least one of: a location of the radiation source or a dwell time of the radiation source.

The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to Trop-2 or CEACAM5 and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 16 mg/kg, preferably 4, 6, 8, 9, 10, 12, or 16 mg/kg. When administered at specified dosages and schedules, the immunoconjugate can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Surprisingly, the immunoconjugate is effective to treat cancers that are refractory to or relapsed from irinotecan.

The invention described herein pertains to the use of oxazolidinone antibiotics, alone or in combination, in the treatment of cancer. In particular, the invention pertains to the treatment of malignant gliomas, thyroid cancer or melanoma, or borderline forms of malignant glioma, thyroid cancer or melanoma.