A neutron activator for neutron activation of a material, the neutron activator being configured to produce neutrons from an interaction with a proton beam (7), the neutron activator comprising: a neutron source comprising a metallic target (1), and a Beryllium first reflector-moderator (4) peripheral to the neutron source and comprising a neutron activation-area (10) configured to accommodate the neutron source and the material to be activated, the neutron activation area (10) of the first reflector-moderator (4) comprising a bore configured to accommodate the neutron source.

A system and method of using machine learning to predict the pharmacokinetics of a therapeutic radiopharmaceutical on a subject patient using the biodistribution data of the patient in order to dynamically treat the patient using the radiopharmaceutical.

Disclosed example gamma radiography sources include an encapsulated quantity of at least 10 Ci of Hafnium-175 (Hf-175). Disclosed example gamma radiation exposure devices include: a gamma radiation source comprising a quantity of Hf-175; and a shielding device configured to attenuate gamma radiation emitted by the gamma radiation source while the gamma radiation source is in a stored position, and configured to allow the gamma radiation source to be moved to an exposed position for gamma radiation exposure.

A device includes an ultrasound probe including an elongated neck insertable in a patient and rotatable around a first longitudinal axis, an ultrasound transducer, and an elongated body rotatable around a second longitudinal axis that is parallel to and offset from the first longitudinal axis. The elongated body is removably attached to a probe mounting structure. A shaft is attached to the probe mounting structure, where rotation of the shaft causes corresponding rotation of the probe mounting structure and the attached elongated body of the ultrasound probe. The shaft defines a longitudinal shaft channel in an interior portion and a longitudinal shaft groove extending from a surface of the shaft to the longitudinal shaft channel. A cable is insertable into the longitudinal shaft channel through the longitudinal shaft groove, and enters an internal channel of the ultrasound probe through the longitudinal shaft channel enabling electrical connection with the ultrasound transducer.

Measuring and tracking energy emitted by a radiation source. A system includes an image sensor for sensing electromagnetic radiation and a scintillator. The scintillator absorbs energy emitted by a radiation source and scintillates the absorbed energy. The system is such that the image sensor senses an image frame depicting at least a portion of the scintillator when the radiation source emits the energy. The image frame comprises an indication of where the energy is absorbed by the scintillator.

The present invention provides an immunomodulator for use in the treatment and/or control of a neoplastic disease in a patient intended to undergo immunogenic cell death therapy simultaneously, separately or sequentially with administration of the immunomodulator. The therapy can be selected from microwave irradiation, targeted radiotherapy, embolization, cryotherapy, ultrasound, high intensity focused ultrasound, cyberknife, hyperthermia, radiofrequency ablation, cryoablation, electrotome heating, hot water injection, alcohol injection, embolization, radiation exposure, photodynamic therapy, laser beam irradiation, and combinations thereof.

A system and method for planning surgical procedure including a treatment zone setting view presenting at least one slice of a 3D reconstruction generated from CT image data including a target. The treatment zone setting view presenting a treatment zone marker defining a location and a size of a treatment zone and configured to adjust the treatment zone marker in response to a received user input. The system and method further including a volumetric view presenting a 3D volume derived from the 3D reconstruction and a 3D representation of the treatment zone marker relative to structures depicted in the 3D volume.

Disclosed herein are methods of treating a patient in need of therapy for prostate cancer comprising delivering a β-radiation-emitting composition into the prostatic vasculature. In some embodiments, an absorbed dose of 60 Gy to 200 Gy is delivered to the prostate. In some embodiments, the β-radiation-emitting composition is delivered into the arterial vasculature of the prostate via a catheter. In some embodiments, the β-radiation-emitting composition comprises a suspension of the β-radiation-emitting particles in an aqueous liquid.

An x-ray treatment system includes an electron beam generator configured to generate an electron beam and an x-ray treatment head comprising an array of pixel source cells including side walls defining an x-ray transmissive interior. The side walls include an x-ray absorptive material. A target element is positioned to, when impacted by the electron beam, generate x-ray photon radiation within the x-ray transmissive pixel source cell interior. An electron beam control system includes a controller configured to control responsive to a treatment plan at least one of the direction and intensity of the electron beam to a particular one of the pixel source cells, and then responsive to the treatment plan to control at least one of the direction and intensity of the electron beam to at least one additional pixel source cell. A method of treating a patient with x-ray photon radiation is also disclosed.

A photocrosslinkable hydrogel may comprise a radioisotope-labeled photocrosslinkable compound or a pharmaceutically acceptable salt thereof, which may be used as a composition for radiotherapy, a composition for radiodiagnostic imaging and a composition for anticancer treatment. The hydrogel is excellent in staying in a local area requiring radiation treatment, so that it can be treated while minimizing damage to surrounding tissues. In addition, it can be used in combination with an anticancer agent and used as a pharmaceutical composition for anticancer treatment, so that cancer can be effectively treated. The hydrogel can be manufactured on site immediately and conveniently using a portable microfluidic system, thereby maximizing the radiation treatment effect.