The disclosure provides systems and methods for adjusting a multi-leaf collimator (MLC). The MLC includes a plurality of cross-layer leaf pairs, each cross-layer leaf pair of the plurality of cross-layer leaf pairs includes a first leaf located in a first layer of leaves and a second leaf opposingly located in a second layer of leaves. For at least one cross-layer leaf pair, an effective cross-layer leaf gap to be formed between the first leaf and the second leaf may be determined; at least one of the first leaf or the second leaf may be caused to move to form the effective cross-layer leaf gap; and an in-layer leaf gap may be caused, based on the effective cross-layer leaf gap, to be formed between the first leaf and an opposing first leaf in the first layer. A size of the in-layer leaf gap may be no less than a threshold.

Presented systems and methods enable efficient and effective radiation treatment planning and treatment, including accurate and convenient transmission of the radiation towards a tissue target. In one embodiment, a radiation system includes a particle source, a bremsstrahlung target, and a pinhole collimator. The particle source is configured to produce a particle beam (e.g., an electron beam, etc.). The bremsstrahlung target is configured to receive the particle beam and generate a photon radiation beam. The received particle beam and generated photon radiation beam can correspond to an inflected image. The inflected image can be associated with a tumor/tissue target. The pinhole collimator is configured to receive the photon radiation beam in a pattern that corresponds to the inflected image, invert the photon radiation beam pattern, and forward the results towards a tissue target.

A method for EPID-based verification, correction and minimization of the isocenter of a radiotherapy device includes the following: Positioning a measurement body; applying an irradiation field; capturing a common dose image of the measurement body; creating a dose profile on the basis of the captured dose image; determining an inflection point in a plot of the dose profile; linking positions of the inflection points to bodily limits of the measurement body; determining position of a center point of the measurement body relative to an EPID-center; determining a differential vector from a deviation in position of the center point of the measurement body from the EPID-center and from a deviation in position of the field center point of the irradiation field from the EPID-center; and correcting the current radiological isocenter.

Techniques for particle beam therapy include receiving a target region inside a subject for particle therapy, a minimum dose inside the target region, and a maximum dose inside the subject but outside target region. Multiple beam axis angles are determined, each involving a gantry angle and a couch position. Multiple spots within the target region are determined. For each beam axis angle a pristine particle scan beam (not coaxial with any other particle scan beam) is determined such that a Bragg Peak is directed to a spot, and repeated until every spot is subjected to a Bragg Peak or an intersection of two or more such pristine scan beams. Output data indicating the pristine beamlets is stored for operation of a particle beam therapy apparatus.

A radiotherapy device and a control driving method thereof are provided. The radiotherapy device includes a radiation source apparatus having a plurality of radiation sources, a source carrier and a collimator. The source carrier includes a source box and a source box region conforming to a shape of the source box, the source box is detachably fixed at the source box region, the plurality of radiation sources are mounted in the source box, the source box is provided with a first connecting part, the source carrier is provided with a second connecting part, and the first connecting part is configured to connect the second connecting part.

A system and method for delivering microbeam radiation therapy (MRT) includes a computed tomography scanner (“CT”) configured to generate tomographic images of a subject, or patient, the scanner including an imaging apparatus, a gantry with an opening for positioning the patient therein, an axis of rotation around which the gantry rotates, and an x-ray source mounted to and rotatable with the gantry. The system includes a bed for patient positioning within the gantry opening and a multi-slit collimator removably mounted downstream of the x-ray source for delivering an array of microbeams of MRT to a targeted portion of the patient. Switching between MRT and CT is provided, and MRT modes of operation include a stationary mode, and continuous and step-wise rotational modes.

Disclosed herein are cancer treatment methods.

A leaf for a multi-leaf collimator comprises a leaf portion for delineating a beam of radiation, the leaf portion having first attenuation factor. The leaf also comprises a tail portion having a second attenuation factor, the first attenuation factor being greater than the second attenuation factor.

A leaf assembly for a multi-leaf collimator comprises a leaf and a leaf nut removably mounted within the profile of the leaf, the leaf nut comprising a threaded hole for receiving a leaf actuator screw oriented along a first axis in the plane of the leaf. The leaf nut is mounted within the leaf such that relative movement between the leaf nut and the leaf is prevented both linearly along the first axis and rotationally about the first axis.

The present disclosure provides a collimating body and a multi-source focusing radiation therapy head. The collimating body includes a first collimating portion and a second collimating portion. The first collimating portion and the second collimating portion are arranged side by side and closely fixed. The first collimating portion includes a first collimating hole set, and the second collimating portion includes a second collimating hole set. The first collimating portion and the second collimating portion are able to move oppositely in a direction perpendicular to a side-by-side direction, so as to align or stagger the first collimating hole set and the second collimating hole set.