A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.

Described is a device for radiotherapy treatment with a high dose rate of ionizing radiation, comprising an accelerating guide (11) of a medical radiofrequency accelerator, at least two simultaneously thermostated resonant cavities (10) and comprising a first pick-up (12), a second pick-up (12B) in at least two resonant cavities (10) and an optical system (20) of the beam.

Disclosed is a radiation and magnetic field generating apparatus irradiating photon beam radiation to in-body affected tissue of a subject. The apparatus includes a radiation generating unit that irradiates the photon beam radiation to the subject and induces generation of secondary electrons in an area of the subject where the photon beam radiation is irradiated, a magnetic field generating unit that includes an insertion structure for forming a low-density space and forms a magnetic field in an area in which the secondary electrons are generated, and a synchronization control unit that controls formation of the magnetic field and controls the formation of the magnetic field such that the secondary electrons move while avoiding normal tissue adjacent to the affected tissue.

The present invention provides strategies to use and control the delivery of ionizing radiation to carry out therapeutic and industrial irradiation treatments. The present invention uses partial pulse control, component selection, and/or component configuration strategies in order to accurately monitor and terminate irradiation. The strategies are particularly useful to control dosing in the high dose rate and short time scales associated with FLASH technology.

Presented systems and methods facilitate efficient and effective generation and delivery of radiation. In one embodiment, an accelerator system includes a particle source, an acceleration portion, a high intensity target, and a target location control component. The particle source is configured to generate charged particles. The acceleration portion is configured to accelerate the charged particles. The high intensity target is configured to generate Bremsstrahlung radiation in response to impact by the charged particles. The target location control component configured to change the location of charged particle impacts on the high intensity target. In one exemplary implementation the change of location of charged particle impact is based on thermal diffusion and said location of charged particle impacts is moved at a rate greater than a rate of diffusion of detrimental heat impacts on the high intensity target.

Presented systems and methods facilitate efficient and effective generation and delivery of radiation. In one embodiment, a radiation generation component includes a high intensity target that produces Bremsstrahlung radiation in response to impacts by charged particles, wherein the high intensity target is configured with operating limitations based primarily on catastrophic failure mechanisms rather than fatigue failure mechanisms. The high intensity target is configured to be compatible with a loading system of a radiation generation system. The high intensity target can have a catastrophic failure strain percentage in the range of 0.5 to 4.0 percent. The catastrophic failure mechanisms can include at least one selected from the group comprising ultimate tensile strength, fracture strain, and melting point. The high intensity target can have a product life in a low cycle fatigue regime range. The high intensity target can comprise a material with a melting temperature in the range of 800 C to 3,700 C. The high intensity target can be configured to load in an accelerator enclosure. The high intensity target can include an identification feature. Th e Bremsstrahlung radiation can correspond to average dose rates greater than 1.0 greys per second (Gy/s).

A particle therapy system includes: an accelerator that accelerates a particle beam; an irradiation system that applies the beam accelerated by the accelerator to a target; and a controller that controls the accelerator and the irradiation system. The controller has a treatment execution system that generates a control parameter which controls the accelerator and the irradiation system based on a treatment plan and has a treatment execution controller that controls the accelerator and the irradiation system based on the control parameter generated by the treatment execution system. When irradiation to the target by the irradiation system is suspended due to a failure or an artificial manipulation, the treatment execution system calculates an irradiated dose of the particle beam and an unirradiated dose of the particle beam, and the treatment execution system delivers at least the unirradiated dose to the treatment execution controller.

The present invention makes it possible to provide a radiation therapy system capable of not only inhibiting treatment time from increasing more effectively than before but also reducing the loads of fluoroscopic radiation photographing apparatuses. The radiation therapy system has: a therapeutic radiation irradiation apparatus to irradiate a target with therapeutic radiation; two fluoroscopic radiation photographing apparatuses to photograph the target simultaneously from two directions; a target position computation apparatus to compute a three-dimensional position of the target on the basis of photographed fluoroscopic images; a therapeutic radiation irradiation control apparatus to control the irradiation of the therapeutic radiation on the basis of the computed three-dimensional position of the target; and a fluoroscopic radiation photographing control apparatus to control irradiation quantities per unit time of the fluoroscopic radiation photographing apparatuses on the basis of the three-dimensional position of the target.

Disclosed are a neutron capture therapy device and an operation method of a monitoring system. The neutron capture therapy device includes a neutron beam irradiation system, a detection system and the monitoring system. The neutron beam irradiation system generates a neutron beam for performing neutron irradiation therapy on a sick body. The detection system is used for detecting irradiation parameters during a neutron beam irradiation therapy, and the monitoring system is used for controlling the whole neutron beam irradiation process. The monitoring system includes a storage part for storing the irradiation parameters, a control part for executing a therapy plan according to the irradiation parameters stored in the storage part, and a correction part for correcting part of the irradiation parameters stored in the storage part. The disclosure improves the accuracy of the dosage of the neutron beam for irradiating the sick body.

Alkylphosphocholine analogs incorporating a chelating moiety that is chelated to gadolinium are disclosed herein. The alkylphophocholine analogs are compounds having the formula: ##STR00001##
or a salt therof. R.sub.1 includes a chelating agent that is chelated to a gadolinium atom; a is 0 or 1; n is an integer from 12 to 30; m is 0 or 1; Y is —H, —OH, —COOH, —COOX, —OCOX, or —OX, wherein X is an alkyl or an arylalkyl; R.sub.2 is —N.sup.+H.sub.3, —N.sup.+H.sub.2Z, —N.sup.+HZ.sub.2, or —N.sup.+Z.sub.3, wherein each Z is independently an alkyl or an aroalkyl; and b is 1 or 2. The compounds can be used to detect solid tumors or to treat solid tumors. In detection/imaging applications, the gadolinium emits signals that are detectable using magnetic resonance imaging. In therapeutic treatment, the gadolinium emits tumor-targeting charged particles when exposed to epithermal neutrons.