Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

A method for delivering radiation treatment may include defining a preliminary trajectory including a plurality of control points. Each control point may be associated with position parameters of a gantry and a couch. The method may also include generating a treatment plan based on the preliminary trajectory by optimizing an intensity and position parameters of a collimator and MLC leaves for each control point. The method may also include decomposing the treatment plan into a delivery trajectory including the plurality of control points. Each of the plurality of control points may be further associated with the optimized intensity, the optimized position parameters of the collimator and the MLC leaves, an output rate, and a motion parameter of each of the gantry, the couch, the collimator, and the MLC leaves. The method may further include instructing a radiation delivery device to deliver the treatment plan according to the delivery trajectory.

A microwave source used in the radiotherapy device can be provided. The microwave source may include an anode block and one or more cathodes. The cathode of the microwave source may include a cathode support element having a plurality of slots. The plurality of slots can be axially around a circumference of the cathode support element. The microwave source may include a cathode heater including at least one filament. A first part of the at least one filament may be wound around the cathode support element along a first direction and received by a first portion of the plurality of slots, and a second part of the at least one filament may be wound around the cathode support element along a second direction and received by a second portion of the plurality of slots.

The invention provides a radiotherapy system and a method for controlling safety interlock thereof. The radiotherapy system includes a beam generating apparatus, which includes a charged particle beam generating apparatus and a neutron beam generating portion interacting with a charged particle beam generated by the charged particle beam generating apparatus to generate a therapeutic neutron beam to irradiate into a first irradiation chamber. In operation, the radiotherapy system determines whether there is a safety problem by a beam control module according to the received operation data of the charged particle beam generating apparatus or by a system control module according to the received operation data of the radiotherapy system, and the beam control module or the system control module controls the charged particle beam generating apparatus through the beam control module, to generate the charged particle beam or not, or interact with the neutron beam generating portion.

The present disclosure is related to a microwave source. The microwave source may include a cathode heater and a thermionic emitter. The cathode heater may include a first component, and a second component enclosing at least a portion of the first component. The thermionic emitter may be configured to release electrons when the thermionic emitter is heated by the cathode heater. At least a portion of the second component of the cathode heater may be in contact with the thermionic emitter.

A computer-based method of optimizing a radiotherapy treatment plan for a patient is proposed, wherein a complete treatment comprising both external beam therapy and brachytherapy is optimized in one procedure using an optimization problem comprising an objective function designed to optimize the total dose distribution as a combination of a first dose distribution to be provided by a first radiation set and a second dose distribution to be provided by a second radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy. The optimization is based on a total desired dose for the whole treatment, images of the patient before the treatment starts and an estimated image of the patient after the first radiation set has been delivered.

A computer-based method of optimizing a radiotherapy treatment plan for a patient is proposed, wherein a treatment plan to be provided by one radiation set is optimized taking into account a previously delivered dose delivered by a different radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy.

To provide a BNCT treatment system capable of formulating a neutron irradiation mode based on diagnostic data on a subject to be treated. A BNCT treatment system 2, used for performing neutron capture therapy, includes: a Hexatron 3 including first to sixth neutron irradiation devices 3A to 3F which emit neutrons; and a controller 4 configured to control neutron irradiation by the first to sixth neutron irradiation devices 3A to 3F. The BNCT treatment system 2 includes: an HOP 5 configured to formulate a treatment plan (a mode for controlling neutron irradiation of the first to sixth neutron irradiation devices 3A to 3F by the controller 4) based on diagnostic data on a patient PA; an HSP 6 configured to monitor each component member; and a management unit 7 configured to manage the entire system.

These teachings facilitate the administration of therapeutic radiation to a heterogeneous patient volume using a radiation beam source. More particularly, these teachings provide for determining a cross-sectional size of a radiation beam as corresponds to that radiation beam source and also for determining density information corresponding to the aforementioned heterogeneous body. These teachings then provide for generating a three-dimensional radiation dose calculation for the heterogeneous body using a control circuit configured as a convolution/superposition based dose calculator using a three-dimensional energy-spreading kernel. By one approach, these teachings provide for the calculator scaling total energy released per mass as a function of the cross-sectional size and energy of the radiation beam and the aforementioned density information.

Disclosed are a neutron capture therapy apparatus and an operation method of a monitoring system thereof. The neutron capture therapy apparatus includes a neutron beam irradiation system, a measurement system and a monitoring system. The neutron beam irradiation system is used for generating a neutron beam suitable for carrying out neutron irradiation therapy on a sick body, the measurement system is used for measuring real-time irradiation parameters during a neutron beam irradiation therapy process, and the monitoring system is used for controlling the whole neutron beam irradiation process. The monitoring system includes an input section for inputting preset irradiation parameters, a storage section for storing the irradiation parameters, a modification section for modifying some of the irradiation parameters in the storage section, and a display section for displaying the irradiation parameters in real time.