The disclosure provides a radiotherapy system, comprising: a bed, for supporting the patient; and a bridge, comprising one or more rolling elements for supporting the bed and allowing the bed to be moved along a surface of the bridge. The one or more rolling elements are located at respective fixed positions in the bridge.

Provided are a radiotherapy device and system. The device includes: a fixed machine frame, a rotary machine frame, an imaging device and a treatment couch disposed on a side of the fixed machine frame. The treatment couch can move away from or close to the fixed machine frame along a first direction. The rotary machine frame is rotatably connected to the fixed machine frame provided with a treatment source; and the imaging device includes a ray emitter and a detector which are disposed oppositely, the ray emitter and/or the detector are/is disposed on the fixed machine frame, and rays emitted by the ray emitter are received by the detector after passing the affected part of patient, for capturing images of the affected part of the patient. The imaging device and the radiotherapy device are integrally designed, thereby effectively improving the locating accuracy of radiotherapy device, and improving effects of radiotherapy.

A volumetric radiation dose detector provides radiation sensors distributed along a closed surface presenting surface normals that vary over a range of azimuth and altitude angles to provide accurate dose modeling for radiation received at a comparable range of angles. Concentric layers of surfaces provide volumetric dose information that can be used to directly produce useful dose maps and assessments.

Various approaches for enhancing treatment of target tissue using a source of focused ultrasound while limiting damage to non-target tissue include selecting a frequency of ultrasound waves transmitted from the source of focused ultrasound for generating a focus in the target tissue; providing microbubbles having the first size distribution such that at least 50% of the microbubbles have a radius smaller than a critical radius corresponding to a resonance frequency matching the selected frequency of ultrasound waves; and applying the ultrasound waves at the selected frequency to treat the target tissue.

Various approaches for disrupting target tissue for treatment include identifying a target volume of the target tissue; causing disruption of the target tissue in a region corresponding to the target volume so as to increase tissue permeability therein; computationally generating a tissue permeability map of the target volume; and based on the tissue permeability map, computationally evaluating the disruption of the target tissue within the target volume.

A particle therapy system includes an accelerator 1 which generates a particle beam for extraction, an irradiation apparatus 21 which irradiates the particle beam to an irradiation target 26, a gantry 18 which rotates together with the irradiation apparatus 21, and an MRI apparatus 50 which rotates together with the gantry 18. The MRI apparatus 50 includes a magnetic circuit composed of an iron core 60 and a plurality of coils 61 serving as a magnetic flux source. The iron core 60 includes two oppositely disposed magnetic poles 63A and 63B, and a return yoke 64 for connecting the magnetic poles 63A and 63B. The magnetic poles 63A, 63B have cavities 65A, 65B. The particle beam passing through the cavity 65A is irradiated to the irradiation target 26.

In certain embodiments novel sparse orthogonal collimators (SOCs) for use in radiotherapy are provided. In certain embodiments the SOCs comprise 2 layer 4 bank orthogonal collimators with 2-8 leaves in each of the 4 banks. Instead of using the limited heuristic approach to create jaw-only IMRT, a novel fluence map optimization method is provided based on wavelet decomposition and this method is used for IMRT. An algorithm to simplify the fluence maps with minimal and predictable dose quality compromise is also provided.

Systems and methods provide radiotherapy treatment by focusing an electron beam on an x-ray target (e.g., a tungsten plate) to produce a high-yield x-ray output with improved field shaping. A modified electron beam spatial distribution is employed to scan the x-ray target, such as a 2D periodic beam path, which advantageously lowers the x-ray target temperature compared to the typical compact beam spatial distribution. As a result, the x-ray target can produce a high yield output without sacrificing the x-ray target life span. The use of a 2D periodic beam path allows a much colder x-ray target functioning regime such that more dosage can be applied in a short period of time compared to existing techniques.

Positioning tool (200) for assisting treatment of a subject in an external radiotherapy programme comprising one or more external radiotherapy treatment sessions comprising: an inserter (204) having a proximal (40) and distal (20) end which inserter comprises: an elongated member (210) configured for insertion through an entrance to a canal (602) in connection with bodily tissue (610) of the subject, and provided with an elongated member lumen (214) configured for receiving an effector shaft (310) of a steering guide (300); and a guiding strand (218) for guiding the effector shaft (310) into the lumen (214) from outside the entrance to the canal, wherein the guiding strand (218) is disposed at least partially within the lumen (214) and is restrained at or towards a distal end (20) of the guiding strand (218) to limit or prevent sliding of the guiding strand (218) in a proximal direction relative to the lumen (214), wherein the positioning tool (200) is configured to move and/or fix the canal (602) and the bodily tissue (610) of the subject relative to an ionising radiotherapy beam for the external radiotherapy treatment session.

Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.