The present invention relates to a composition for improvement of female menopausal (climacteric) disorders, comprising as an active ingredient a combination of a red clover extract and a hops extract, more specifically a food composition for improvement of women's menopausal disorders or a pharmaceutical composition for prevention or treatment of women's menopausal disorders, comprising as an active ingredient a combination of a red clover extract and a hops extract; and a method for preparing said composition for improvement of women's menopausal disorders.

The present invention relates to a composition for improvement of female menopausal (climacteric) disorders, comprising as an active ingredient a combination of a red clover extract and a hops extract, more specifically a food composition for improvement of women's menopausal disorders or a pharmaceutical composition for prevention or treatment of women's menopausal disorders, comprising as an active ingredient a combination of a red clover extract and a hops extract; and a method for preparing said composition for improvement of women's menopausal disorders.

The disclosure provides the use of a plant in the preparation of medicines and health products for preventing and treating ovarian injury. The application found that seabuckthorn fruit pulp and seabuckthorn seed oil have good preventive and therapeutic effects on ovarian injury. Seabuckthorn fruit pulp and seabuckthorn seed oil can prevent mouse ovarian injury and estrus cycle disorders, and can improve ovarian reserve, etc. Meanwhile, they also have good therapeutic effects on the above-mentioned injuries. This application provides a basis for the prevention and treatment of ovarian injury directly by seabuckthorn fruit pulp and seabuckthorn seed oil.

The disclosure provides the use of a plant in the preparation of medicines and health products for preventing and treating ovarian injury. The application found that seabuckthorn fruit pulp and seabuckthorn seed oil have good preventive and therapeutic effects on ovarian injury. Seabuckthorn fruit pulp and seabuckthorn seed oil can prevent mouse ovarian injury and estrus cycle disorders, and can improve ovarian reserve, etc. Meanwhile, they also have good therapeutic effects on the above-mentioned injuries. This application provides a basis for the prevention and treatment of ovarian injury directly by seabuckthorn fruit pulp and seabuckthorn seed oil.

Provided herein are compounds, such as compounds of Formula I, that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions. ##STR00001##

An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc.

The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.

The present disclosure encompasses solid state forms of Fezolinetant, including salts and cocrystals of Fezolinetant, in embodiments crystalline polymorphs of Fezolinetant, processes for preparation thereof, and pharmaceutical compositions thereof.

The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

Embodiments are directed to secnidazole formulations and the use of a secnidazole formulation for the treatment of trichomoniasis in a subject in need thereof.