Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.

Cyclic peptides that are inhibitors of a pathogenic free-living amoeba (e.g., Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii), compositions comprising the same, and their use for inhibiting infections or diseases caused by the pathogenic free-living amoeba.

Cyclic peptides that are inhibitors of a pathogenic free-living amoeba (e.g., Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii), compositions comprising the same, and their use for inhibiting infections or diseases caused by the pathogenic free-living amoeba.