The present invention pertains to inter alia therapeutic delivery vesicles, for instance exosomes or microvesicles, comprising polypeptide constructs, methods for producing said therapeutic delivery vesicles, pharmaceutical compositions and medical uses thereof. The therapeutic polypeptide constructs comprised in the extracellular delivery vesicles enable sequestering target molecules of interest, to treat e.g. neuro-inflammatory diseases and cancer.

A single-screw compressor includes a screw rotor with a helical groove, a cylindrical wall rotatably housing the screw rotor, a gap adjuster mechanism, and a gear-shaped gate rotor having a plurality of flat gates. The gate rotor is arranged outside the wall. Some of the gates enter a space inside the wall via an opening formed in the cylindrical wall and mesh with the screw rotor. A fluid is compressed in a compression chamber defined in the helical move by the screw rotor, the gates meshing with the screw rotor, and the wall. The gap adjuster mechanism avoids contact between a front surface of the gate rotor toward the compression chamber and a sealing surface of the wall facing the front surface, by displacing at least one of the gate rotor and the sealing surface of the wall in an axial direction of the gate rotor.

A vane pump includes: a casing forming a pump chamber therein; a rotor arranged inside the casing to rotate eccentrically with respect to the casing; and a plurality of vanes configured to rotate with the rotor and slide on an inner side surface of the casing. At least one of Formula (1): I(b/a)k and Formula (2): I(c/a)j is satisfied, where a represents a height of the pump chamber, b represents a height of the rotor, c represents a height of the vane in a rotation axis direction of the rotor, and where I represents a linear expansion coefficient of the casing in the rotation axis direction, k represents a linear expansion coefficient of the rotor in the rotation axis direction, and j represents a linear expansion coefficient of the vane in the rotation axis direction.

A vane pump includes: a casing forming a pump chamber therein; a rotor arranged inside the casing to rotate eccentrically with respect to the casing; and a plurality of vanes configured to rotate with the rotor and slide on an inner side surface of the casing. At least one of Formula (1): I(b/a)k and Formula (2): I(c/a)j is satisfied, where a represents a height of the pump chamber, b represents a height of the rotor, c represents a height of the vane in a rotation axis direction of the rotor, and where I represents a linear expansion coefficient of the casing in the rotation axis direction, k represents a linear expansion coefficient of the rotor in the rotation axis direction, and j represents a linear expansion coefficient of the vane in the rotation axis direction.

A rotary compressor may include a rotary shaft; a plurality of plates that supports the rotary shaft; a cylinder provided between the plurality of plates to define a compression space, and provided with a vane slot; a roller slidably coupled to the rotary shaft inside of the cylinder, and having a hinge groove on an outer circumferential surface thereof; and a vane, a first end of which is slidably coupled to the vane slot of the cylinder, and a second end of which is rotatably coupled to the hinge groove of the roller. At least one of first and second axial end surfaces of the roller facing the plurality of plates is provided with a dimple portion having a predetermined depth. With this structure, contact surfaces between the roller and the plate may be prevented from being in close contact with each other, preventing the roller or the plate from being damaged or a performance of the compressor from deteriorating due to friction loss, thereby improving reliability and performance of the compressor.

A rotary compressor may include a rotary shaft; a plurality of plates that supports the rotary shaft; a cylinder provided between the plurality of plates to define a compression space, and provided with a vane slot; a roller slidably coupled to the rotary shaft inside of the cylinder, and having a hinge groove on an outer circumferential surface of the roller; and a vane, a first end of which is slidably coupled to the vane slot of the cylinder, and a second end of which is rotatably coupled to the hinge groove of the roller. When an imaginary line passing through an axial center of the rotary shaft and a hinge center of the vane is a first center line, and a radial center line of the vane slot passing through the hinge center of the vane is a second center line, the vane slot is disposed such that the second center line is intersected by a predetermined tilting angle with respect to the first center line. With this structure, a roller reaction force is canceled to suppress an increase in side pressure or side wear between a vane and a vane slot into which the vane is inserted.

A rotary compressor may include a rotary shaft; a plurality of plates that supports the rotary shaft; a cylinder provided between the plurality of plates to define a compression space, and provided with a vane slot; a roller slidably coupled to the rotary shaft inside of the cylinder, and having a hinge groove on an outer circumferential surface thereof; and a vane, a first end which is slidably coupled to the vane slot of the cylinder, and a second end of which is rotatably coupled to the hinge groove of the roller. At least one of axial end surfaces of the roller facing the plurality of plates is provided with a wear avoiding portion having a predetermined depth. Contact surfaces between the roller and the plate may be suppressed from being in close contact with each other to suppress the roller or the plate from being damaged or a performance of the compressor due to friction loss from being deteriorated, thereby improving reliability and performance of the compressor.

A stator-rotor system of an eccentric screw pump including a rotor with a rotor screw and a stator with an internal thread. The stator includes a support element and an elastomer part. The support element surrounds the elastomer part in sections around the whole circumference. The stator-rotor system includes a mechanism for adjusting the stator, having two adjustment elements arranged on the stator-rotor system, which are distance-variable relative to one another. In a first working position the two adjustment elements have a first distance from one another and in a second working position, a second distance. The cross-section and the length of the elastomer part of the stator in the second working position are changed compared to the cross-section and the length of the elastomer part in the first working position.

A scroll compressor is provided that may include a casing; a drive motor provided at an inner space of the casing; a rotational shaft coupled to a rotor of the drive motor, and rotated together with the rotor; a frame provided below the drive motor; a fixed scroll provided below the frame, and having a fixed wrap; and an orbiting scroll provided between the frame and the fixed scroll, having an orbiting wrap so as to form a compression chamber including a suction chamber, an intermediate pressure chamber, and a discharge chamber, by being engaged with the fixed wrap. In a state in which a center of the fixed scroll and a center of the orbiting scroll are substantially the same, an interval between the fixed wrap and the orbiting wrap gradually increases towards the suction chamber from the discharge chamber.

The present invention pertains to inter alia therapeutic delivery vesicles, for instance exosomes or microvesicles, comprising polypeptide constructs, methods for producing said therapeutic delivery vesicles, pharmaceutical compositions and medical uses thereof. The therapeutic polypeptide constructs comprised in the extracellular delivery vesicles enable sequestering target molecules of interest, to treat e.g. neuro-inflammatory diseases and cancer.