This invention describes a design for a multiwell plate that contains integrated pumps that are used to stir each well of the plate. The device employs microfluidic logic technology to drive each peristaltic pump. This enables the plates to run autonomously, requiring only a static vacuum supply for power. The devices are entirely constructed out of low-cost polymers, with no electronics, and yet contains simple digital logic circuits to control the pumps. A stack of these plates may be run continuously in a standard cell culture incubator, allowing high-throughput culture of organoids.

A conveying device at least for conveying a conveying medium includes at least one conveying space, with at least one conveying space element, which at least partly delimits the conveying space and is embodied in a rigid fashion, and with at least one elastically deformable conveying element which delimits the conveying space together with the conveying space element. The conveying space element includes at least one concave recess for at least partly forming the conveying space, wherein an inner surface of the conveying space element, which delimits the concave recess, forms a wall of the conveying space, wherein the conveying element comprises at least one conveying surface, which is utilizable in targeted fashion for a conveyance of a fluid in the conveying space and/or through the conveying space.

An electric pump includes a transmission unit that transmits rotational drive of a motor unit, a pump unit, and a rotary valve unit. The pump unit expands and contracts a pump chamber to draw in a fluid from an inlet and discharge the fluid from an outlet. The rotary valve unit includes a valve body and a valve cover. The valve body is rotated by the rotational drive force transmitted by the transmission unit. The valve cover includes a valve-side inlet that draws in a fluid and a plurality of fluid outlets that discharges the fluid to the exterior. The rotary valve unit is configured to switch the fluid outlets that come into communication with the inlet in accordance with rotational drive of the valve body. The valve body is intermittently driven by an intermittent drive mechanism that converts continuous drive corresponding to the rotational drive force into intermittent drive.

An infusion device (3) comprises a housing element (30) having a receptacle (301) for receiving a pump module (1), and a pump actuation mechanism (2) having a wobbling device (20) arranged on the housing element (30) and a drive shaft (21) being rotatable about a rotational axis (A). The wobbling device (20) is actuatable, by rotating the drive shaft (21) about the rotational axis (A), to perform a tumbling motion with respect to the receptacle (300) for acting onto the pump module (1) received in the receptacle (300) in order to pump a fluid through the pump module (1). Herein, the wobbling device (20) is displaceable along at least one direction (X, Y) transverse to the rotational axis (A) with respect to the receptacle (300). In this way an infusion device is provided which in an easy and cost-efficient manner allows for improving the positional accuracy of the pump module with respect to the wobbling device of the pump actuation mechanism upon arranging the pump module on the receptacle of the housing element.

An infusion device comprises a pump device (1) having a housing part (103) and a flexible wall section (120) together forming a pump channel (121) through which a fluid is to be pumped, wherein the pump channel (121) has a first end (120A) as inlet for a fluid and a second end (120B) as outlet for a fluid, wherein the pump channel (121) extends along a channel length (C) between the first end (120A) and the second end (120B). The infusion device further comprises a pump actuation mechanism (2) having an actuation device (20) for acting onto the flexible wall section (120) along the channel length (C) of the pump channel (121) for locally depressing the flexible wall section (120) in a vertical direction (Z) in order to pump a fluid through the pump channel (121), the actuation device (20) being displaceable with respect to a housing section (22) of the pump actuation mechanism (2) along the vertical direction (Z). A control device (25) controls the operation of the pump actuation mechanism (2), wherein, for pumping a fluid through the pump channel (121), the actuation device (20) is actuated to depress the flexible wall section (120) at a depression location (A), wherein the depression location (A) during one pump cycle moves along the channel length (C) of the pump channel (121). Herein, for calibrating the infusion device, the position of the actuation device (20) along the vertical direction (Z) during one pump cycle is measured to obtain a measured profile, a difference between the measured profile and a nominal profile prestored in the control device (25) is formed to obtain a difference profile, and from the difference profile a characteristic value for correcting and/or checking the pump operation of the infusion device is calculated.

A diaphragm pump such as a three-chamber diaphragm pump includes a head having an inlet port and an outlet port and defining an inlet side including inlet chambers; and an outlet side having a center outlet chamber. Each of the inlet chambers includes an associated inlet valve. A single shutoff valve controlling fluid flow to the center outlet chamber and a single bypass valve in fluid communication between the center outlet chamber and the inlet side. The single shutoff valve has a plunger with an oval cross-section extending into the center outlet chamber. The single shutoff valve and the single bypass valve have adjustable pressure set points that are adjustable independently of one another.

A rotary pump in a housing which defines an annular chamber with an inlet and outlet port which are located on either side of a partition which extends across the chamber. A flexible annular diaphragm forms one side of the chamber and faces a wall on the housing which forms the second side of the chamber. The diaphragm is sealed at its innermost and outermost edges to the housing and has legs extending away azimuthally around and integral with the diaphragm. A swashplate is connected to the legs of the diaphragm such that in use, movement of the swashplate causes the diaphragm to press precessively against the wall of the housing to force fluid drawn in at the inlet on one side of the partition around the chamber and to expel the fluid at the outlet at the other side of the partition.

A fluid pump comprising a conical body having an apex, a base and defining a lateral surface between the apex and base; a mating surface defined by a pump plate; a flexible membrane having a first face comprising a first part which is attached to at least a portion of the lateral surface of the conical body and a second part which is free, and having a second, opposite face secured around its periphery to the mating surface; and a driver adapted to drive the conical body; wherein the mating surface includes a fluid inlet port and a fluid outlet port, the fluid inlet port being spaced from the fluid outlet port; the driver includes a drive shaft and a drive plate carried by the distal end of the drive shaft, wherein the drive plate is inclined with respect to a plane normal to a longitudinal axis of the drive shaft such that the drive plate drives the conical body to precess about its apex in use such that at any given time the flexible membrane defines a contact portion in contact with the mating surface where the lateral surface of the conical body is adjacent to the mating surface, and defines a non-contact portion which is spaced from the mating surface; a pump chamber is defined by a cavity formed between the non-contact portion of the flexible membrane and the mating surface; the pump chamber rotates about an axis of the mating surface as the conical body precesses about its apex; and fluid is drawn into the pump chamber as it passes the fluid inlet port and the fluid is urged out of the pump chamber as it passes the fluid outlet port.

A diaphragm pump such as a three-chamber diaphragm pump includes a head having an inlet port and an outlet port and defining an inlet side including inlet chambers; and an outlet side having a center outlet chamber. Each of the inlet chambers includes an associated inlet valve. A single shutoff valve controlling fluid flow to the center outlet chamber and a single bypass valve in fluid communication between the center outlet chamber and the inlet side. The single shutoff valve has a plunger with an oval cross-section extending into the center outlet chamber. The single shutoff valve and the single bypass valve have adjustable pressure set points that are adjustable independently of one another.