An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.

A device providing a dosed supply of a liquid includes: a pump configured to deliver the liquid and having a pump housing with an inlet and an outlet; an eccentric on the pump housing; and a deformable diaphragm between the pump housing and the eccentric, the deformable diaphragm and the pump housing delimiting a delivery path from the inlet to the outlet and forming a seal of the delivery path. The seal is displaceable along the delivery path, by a movement of the eccentric, in a delivery direction from the inlet to the outlet to deliver the liquid. The pump is configured such that within the pump a friction torque that must be overcome for the eccentric to move is greater than a maximum pressure torque that can be generated by pressurized liquid in the delivery path, so as to prevent movement of the eccentric counter to the delivery direction.

A device providing a dosed supply of a liquid includes: a pump configured to deliver the liquid and having a pump housing with an inlet and an outlet; an eccentric on the pump housing; and a deformable diaphragm between the pump housing and the eccentric, the deformable diaphragm and the pump housing delimiting a delivery path from the inlet to the outlet and forming a seal of the delivery path. The seal is displaceable along the delivery path, by a movement of the eccentric, in a delivery direction from the inlet to the outlet to deliver the liquid. The pump is configured such that within the pump a friction torque that must be overcome for the eccentric to move is greater than a maximum pressure torque that can be generated by pressurized liquid in the delivery path, so as to prevent movement of the eccentric counter to the delivery direction.

The present invention provides such pumping apparatuses that have very little deviation and high stability in pumping flow. A pumping apparatus comprises two members that are set along a longitudinal direction of a tube made of an elastic material with a relation that the space formed by grooves made in the two members holds the tube. The two members have reciprocal motion such that at least one of the two opposing members shuttles in parallel with the other opposing member and has a move-in motion such that at least one of the two opposing members vertically moves to the opposing surfaces of the other opposing member so that surrounding part of the groove thereof moves into an inner space of the groove of the other opposing member, by which motion the liquid in the tube is discharged from the tube by the deformation of tube cross sectional shape.

The present invention provides such pumping apparatuses that have very little deviation and high stability in pumping flow. A pumping apparatus comprises two members that are set along a longitudinal direction of a tube made of an elastic material with a relation that the space formed by grooves made in the two members holds the tube. The two members have reciprocal motion such that at least one of the two opposing members shuttles in parallel with the other opposing member and has a move-in motion such that at least one of the two opposing members vertically moves to the opposing surfaces of the other opposing member so that surrounding part of the groove thereof moves into an inner space of the groove of the other opposing member, by which motion the liquid in the tube is discharged from the tube by the deformation of tube cross sectional shape.

The present disclosure provides apparatuses and methods related to a high pressure processing device that is configured to simplify batch processing. In an embodiment, a high pressure processing device includes a processing module configured to reduce a particle size of a material or achieve a desired liquid processing result for the material, a pump configured to pump the material to an inlet of the processing module, a recirculation pathway configured to recirculate the material from an outlet of the processing module back to the pump, an input device configured to receive at least one user input variable, and a controller configured to (i) determine a number of pump strokes for the pump based on the user input variable, and (ii) control the pump according to the determined number of pump strokes so that the material makes a plurality of passes through the processing module.

A device for performing a microfluidic assay on a chip comprising, a microfluidics chip, one or more fluid receptacles on the chip for receiving a fluid, a plurality of pneumatic pumps arrayed on the chip, each pump having a discharge channel leading to a rectifier on the chip, and a reaction chamber in fluid communication with each of the rectifiers, wherein a pressure on the pressurized fluid source drives fluid from the fluid receptacle into the incoming fluid channel connecting the fluid receptacle to the pump, through the pump and into the discharge channel, through the discharge channel to the rectifier, and through the rectifier into the reaction chamber, wherein the pump is configured to generate droplets of a pre-determined size, wherein the rectifiers prevent backflow of the droplets, and wherein droplets are combined in the reaction chamber, the chamber facilitating an assay being performed on the chip.

An apparatus for creating a flow of gas comprises a frame having a passage defined therethrough. The passage extends a length along a central longitudinal axis from an inlet to an outlet and has a first side and a second side. A flexible pumping membrane is disposed within the passage. The membrane has a first edge coupled to the first side of the passage at a midline thereof and a second edge, disposed opposite the first edge, coupled to the second side of the passage at a midline thereof. The membrane segregates the frame into an upper portion and a lower portion. The apparatus also includes an actuating system which is structured to selectively move portions of the membrane toward either the upper portion or the lower portion of the frame in a manner which causes a wave-like movement in the pumping membrane and creates the flow of gas.

An apparatus for creating a flow of gas comprises a frame having a passage defined therethrough. The passage extends a length along a central longitudinal axis from an inlet to an outlet and has a first side and a second side. A flexible pumping membrane is disposed within the passage. The membrane has a first edge coupled to the first side of the passage at a midline thereof and a second edge, disposed opposite the first edge, coupled to the second side of the passage at a midline thereof. The membrane segregates the frame into an upper portion and a lower portion. The apparatus also includes an actuating system which is structured to selectively move portions of the membrane toward either the upper portion or the lower portion of the frame in a manner which causes a wave-like movement in the pumping membrane and creates the flow of gas.

An electrostatic zipping actuator includes a primary electrode, a secondary electrode overlying the primary electrode, a dielectric layer located between and abutting at least a portion of the primary electrode and the secondary electrode, and a dielectric fluid disposed at least at a junction between the dielectric layer and one of the electrodes, where an average total thickness of the dielectric layer is less than approximately 10 micrometers.