Fluidic systems including cartridges comprising vessels, microfluidic channels and related methods for performing chemical and/or biological analyses are generally provided. The systems described herein include, according to certain embodiments, a cartridge comprising a vessel adapted and arranged to contain a fluid and/or reagent for performing a chemical and/or biological analysis. The vessel may be designed to have a particular shape or configuration, such as a tapered cross-sectional shape, e.g., to facilitate manipulation of a fluid and/or reagent within the vessel (e.g., a lyosphere).

Fluidic systems including cartridges with modular components (cassettes) and/or microfluidic channels for performing chemical and/or biological analyses are provided. The systems described herein include a cartridge comprising, in some embodiments, a frame, one or more cassettes which may be inserted into the frame, and a channel system for transporting fluids. In certain embodiments, the one or more cassettes comprise one or more reservoirs or vessels configured to contain and/or receive a fluid (e.g., a stored reagent, a sample). In some cases, the stored reagent may include one or more lyospheres. The systems and methods described herein may be useful for performing chemical and/or biological reactions including polymerase chain reactions (PCR) such as those performed within a laboratory, clinical (e.g., hospital), or research setting.

Devices and related methods for automated processing of nucleic acids are provided herein. In some aspects, the application relates to devices comprising at least two cartridge bays having at least one shared resource which is shared between or among the at least two cartridge bays.

Fluidic systems including cartridges with modular components (cassettes) and/or microfluidic channels for performing chemical and/or biological analyses are provided. The systems described herein include a cartridge comprising, in some embodiments, a frame, one or more cassettes which may be inserted into the frame, and a channel system for transporting fluids. In certain embodiments, the one or more cassettes comprise one or more reservoirs or vessels configured to contain and/or receive a fluid (e.g., a stored reagent, a sample). In some cases, the stored reagent may include one or more lyospheres. The systems and methods described herein may be useful for performing chemical and/or biological reactions including polymerase chain reactions (PCR) such as those performed within a laboratory, clinical (e.g., hospital), or research setting.

Biological analysis system and methods for operating devices of the system are provided. A library preparation device of the biological analysis system may perform a library preparation protocol on a biological sample, where the library preparation protocol is determined based on information from an encoded identifier associated with the biological sample and a resource to be used by the library preparation device. A sequencing device may perform a sequencing process on a library prepared by the library preparation device. Configuration of the sequencing device to perform the process may include receiving sample information generated by the library preparation device and processing the sample information to generate configuration information for the sequencing device. Results from the sequencing process may be analyzed to determine nucleic acid sequences based on the sample information.

A driving power transmission device includes a fluid pressure type clutch device that transmits driving power between two shaft members, and a pump that supplies a fluid to the clutch device. The pump includes a pump that makes a pressure of sucked fluid high; a first flow passage through which the fluid according to a pressure discharged from the pump is supplied to the clutch device during a driving of the pump; a second flow passage through which the fluid discharged from the pump is held during a stop of the pump and a pressing force is applied to the clutch device by the fluid to be held; and a switching valve that is switchable between a normal mode where a discharge port of the pump communicates with the first flow passage and a locking mode where the discharge port of the pump communicates with the second flow passage.

A driving power transmission device includes a fluid pressure type clutch device that transmits driving power between two shaft members, and a pump that supplies a fluid to the clutch device. The pump includes a pump that makes a pressure of sucked fluid high; a first flow passage through which the fluid according to a pressure discharged from the pump is supplied to the clutch device during a driving of the pump; a second flow passage through which the fluid discharged from the pump is held during a stop of the pump and a pressing force is applied to the clutch device by the fluid to be held; and a switching valve that is switchable between a normal mode where a discharge port of the pump communicates with the first flow passage and a locking mode where the discharge port of the pump communicates with the second flow passage.

An oscillating pump system includes a pump operable to circulate a fluid. The pump has a first port stage including an inlet port and an outlet port and a second port stage including a first oscillating port and a second oscillating port. An oscillator disk is disposed between the first port stage and the second port stage. The oscillator disk is rotatable relative to the inlet port, the outlet port, the first oscillating port and the second oscillating port. During rotation, the oscillator disk alternatingly routes the fluid to the inlet port from the first and second oscillating ports and alternatingly routes the fluid from the outlet port to the first and second oscillating ports, thereby generating oscillating fluid flow.

An oscillating pump system includes a pump operable to circulate a fluid. The pump has a first port stage including an inlet port and an outlet port and a second port stage including a first oscillating port and a second oscillating port. An oscillator disk is disposed between the first port stage and the second port stage. The oscillator disk is rotatable relative to the inlet port, the outlet port, the first oscillating port and the second oscillating port. During rotation, the oscillator disk alternatingly routes the fluid to the inlet port from the first and second oscillating ports and alternatingly routes the fluid from the outlet port to the first and second oscillating ports, thereby generating oscillating fluid flow.

A disc valve assembly for control of a flow of hydraulic fluid in a hydraulic fluid system may include a disc element comprising an inlet facing side and a second side opposite to the inlet facing side, and flow pathways configured as a plurality of different pressure zones with the flow pathways extending axially along a longitudinal axis of the disc element from at or adjacent to the inlet facing side to the second side. A valve housing houses the disc element and includes porting configured as part of the plurality of different pressure zones respectively in fluid communication with the flow pathways of the disc element. The disc element is configured to rotate to control a flow of hydraulic fluid through the disc valve assembly. The different pressure zones are isolated from each other using a plurality of annular sealing rings located on the inlet facing side of the disc element.