A method of forming an encapsulated composition with enhanced solubility and stability. A bicontinuous or Winsor Type III microemulsion is formed using an emulsifier, a solvent and a co-emulsifier. An active composition is added to the microemulsion resulting in a micellar network of the active composition within the microemulsion. The active composition can be either water-soluble or oil-soluble or both.

The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

A self-emulsifying composition contains: 70 to 90% by weight in total of one or more compounds selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 1 to 29% by weight of an emulsifying agent selected from among a polyoxyethylene sorbitan fatty acid ester, a sorbitan fatty acid ester, a glycerin fatty acid ester and a polyoxyl castor oil; and 0.5 to 6% by weight of water when the composition is defined to be 100% by weight as a whole. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.

A self-emulsifying composition contains: 70 to 90% by weight in total of one or more compounds selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 1 to 29% by weight of an emulsifying agent selected from among a polyoxyethylene sorbitan fatty acid ester, a sorbitan fatty acid ester, a glycerin fatty acid ester and a polyoxyl castor oil; and 0.5 to 6% by weight of water when the composition is defined to be 100% by weight as a whole. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.

Disclosed herein is a formulation that can take the form of an emulsion which contains total enteral or parenteral nutrition for a recipient subject. The formulation includes as the sole fat components: (i) medium chain triglycerides; and (ii) very long chain fatty acids selected from (a) very long chain omega-3 polyunsaturated fatty acids; and (b) docosahexaenoic acid and arachidonic acid in a ratio of about 10:1 (v/v or w/w) to about 2000:1 (v/v or w/w). The sole fat components provide about 10% to about 90% total calories of the formulation, and the medium chain triglycerides provide about 25%-95% total fat calories of the formulation. Methods and kits for utilizing the formulation and for treating various disorders and diseases that involve an inflammatory response are also disclosed.

Disclosed herein is a formulation that can take the form of an emulsion which contains total enteral or parenteral nutrition for a recipient subject. The formulation includes as the sole fat components: (i) medium chain triglycerides; and (ii) very long chain fatty acids selected from (a) very long chain omega-3 polyunsaturated fatty acids; and (b) docosahexaenoic acid and arachidonic acid in a ratio of about 10:1 (v/v or w/w) to about 2000:1 (v/v or w/w). The sole fat components provide about 10% to about 90% total calories of the formulation, and the medium chain triglycerides provide about 25%-95% total fat calories of the formulation. Methods and kits for utilizing the formulation and for treating various disorders and diseases that involve an inflammatory response are also disclosed.

An objet of the present invention is to provide an emulsion composition, a powdery matter and a production method of an emulsion composition, each enabling superior stability of the emulsion.

[Means for Resolution]

An emulsion composition according to one embodiment of the present invention contains a coconut oil, a lecithin and a co-emulsifier. The co-emulsifier is preferably a polyhydric alcohol having at least two hydroxyl groups. The co-emulsifier is preferably propylene glycol, glycerol, sorbitol, xylitol, maltitol, mannitol, glucose, galactose, mannose, lactose, fructose, maltose, sucrose, xylose, trehalose or guar gum. The emulsion composition preferably further contains deionized water. The emulsion composition preferably further contains honey, collagen, inositol, glutathione or potassium sorbate. A powdery matter according to another aspect of the present invention contains a coconut oil, a lecithin and a co-emulsifier. The powdery matter is preferably water soluble.

An objet of the present invention is to provide an emulsion composition, a powdery matter and a production method of an emulsion composition, each enabling superior stability of the emulsion.

[Means for Resolution]

An emulsion composition according to one embodiment of the present invention contains a coconut oil, a lecithin and a co-emulsifier. The co-emulsifier is preferably a polyhydric alcohol having at least two hydroxyl groups. The co-emulsifier is preferably propylene glycol, glycerol, sorbitol, xylitol, maltitol, mannitol, glucose, galactose, mannose, lactose, fructose, maltose, sucrose, xylose, trehalose or guar gum. The emulsion composition preferably further contains deionized water. The emulsion composition preferably further contains honey, collagen, inositol, glutathione or potassium sorbate. A powdery matter according to another aspect of the present invention contains a coconut oil, a lecithin and a co-emulsifier. The powdery matter is preferably water soluble.

Disclosed is a method for making a shelf-stable organic compound in a more water-soluble form, the higher-solubility form being provided in liquid and/or powder. The method utilizes a surfactant solution comprising lecithin, water, and at least one polysaccharide into which at least one limited-solubility organic compound is admixed to form a dispersion.