Provides is an anti-obesity composition, including a low-temperature Geumhwagyu extract as an active ingredient. The extract was obtained by adding Geumhwagyu to low-temperature water at 4 to 50° C. and extracting for 1 to 20 hours. The extract increases energy consumption through an increase in expression of adipose triglyceride lipase (ATGL) and hormone-sensitivity lipase (HSL), lipolysis through inhibition of expression of perilipin-1, and thermal generation through an increase in expression of uncoupling protein (UCP). In addition, the extract improves energy metabolism by increasing the expression of phospho-AMP-activated protein kinase (AMPK), inhibits lipid formation and accumulation of adipocytes by inhibiting cell growth of mature adipocytes, and shows anti-obesity activity, thereby being easily used as a pharmaceutical composition and healthy functional food for obesity.

A solvent-free method to extract THCA from cannabis, said method comprising: providing a source of THCA-containing cannabis plant; providing a source of natural oil; combining said source of THCA-containing cannabis and said source of natural oil into a blend; milling said blend; optionally, heating the blend during the milling; and extracting a THCA-containing liquid generated during the milling.

Methods and compositions for use in treating, preventing or improving diseases related to the liver in an animal, including but not limited to nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) or nonalcoholic steatohepatitis (NASH), are described. The compounds of the present invention are gamma-ketoaldehyde scavengers.

The present invention is directed to multiparticulate granulate compositions comprising particles of insulin and particles of an infant nutritional excipient, wherein the multiparticulate granulate is substantially free of layers of insulin and excipient, methods of making thereof, and methods of use thereof.

The use of and a method using a diet composition for enhancing lean body mass/muscle mass is provided. The diet composition includes a fasting-mimicking diet (FMD) component to be administered for a first time period of reduced calorie intake of 24 to 190 hours. The fasting-mimicking diet component provides less than 50% of the normal calorie intake of the subject with both protein restriction and sugar restriction. The diet composition can also include a re-feeding diet component to be administered for a second time period. Characteristically, the re-feeding diet component providing 60-100% of the normal calorie intake of the subject. Advantageously, the fasting-mimicking diet component and the re-feeding diet component are administered for multiple cycles.

A composition, such as a dietary composition is disclosed containing one or more capsaicinoids contained within a lipid matrix. In one embodiment, the composition contains a liquid capsaicin in addition to a capsaicin wax. The composition is formulated such that when is ingested does not break down in the stomach but instead releases the capsaicin in the small intestines for various dietary benefits, including appetite suppression.

The present disclosure relates to a non-therapeutic use of whey protein micelles to enhance muscle protein synthesis in a subject. Further aspects are directed to food compositions comprising whey protein micelles to be administered to children, athletes, or elderly persons.

The present invention refers to nutritional composition comprising sn-1(3) monoacylglycerols for use in the treatment or prevention of maldigestion and/or malabsorption in an infant or young child. It also refers to a nutritional composition comprising sn-1(3) monoacylglycerols for use to increase lipid (e.g. fatty acids) absorption/delivery and/or to increase the energy or the mineral bioavailability in an infant or young child. The infant or young child may have a gut immaturity and/or a reduced enteral feeding tolerance. They may also be pretermand/or low birth weight.

This invention relates to the use of a nutritional composition comprising Fut2-dependent oligosaccharides for promoting brain growth and development in infants in the very early postnatal period. The nutritional composition comprises Fut2-dependent oligosaccharides and Lacto-N-neotetraose and is specifically for use in promoting brain catch-up growth in preterm infants or infants with low-birth weight. The invention further relates to a kit comprising at least two of these nutritional compositions.

The present disclosure relates to a composition for preventing or treating metabolic diseases, in which the composition includes Bacteroides acidifaciens as an active ingredient. In addition, the present disclosure relates to a composition for oxidizing fat or inhibiting DPP-4, in which the composition includes Bacteroides acidifaciens as an active ingredient. In addition, the present disclosure relates to a transformant expressing a lean phenotype, in which an Atg7 gene is deleted in dendritic cells.