Fluidic connection assemblies, ports, unions and other components are provided that are well-suited for use in HPLC and UHPLC, as well as in other analytical instrument systems. Such assemblies, ports, unions and components can be biocompatible.

A quick-access hinged lid assembly for flanged riser, having two-part clamp, having an inner face shaped to conform to the surface flanged riser, first clamp ring and second clamp ring are connected by a clamp hinge, a lid having an exterior surface and an interior sealing surface to abut the flanged riser exterior surface, wherein the interior sealing surface includes annular groove, gasket or o-ring positioned therein groove to seal flanged riser exterior surface and interior sealing surface, a lid hinge configured between clamp and lid, lid hinge having a swing bolt slot and pin bolt to provide adjustment of the lid to enable the lid to mate flat with flanged riser, swing bolts positioned on the perimeter and pivotable from the clamp ring with hand operable fasteners to press gasket between interior sealing surface of the lid and flanged riser exterior surface in a closed position.

Described is a coupling seal that includes a polymeric body having a bore extending from a first end to an internal sealing surface and a fluid channel extending from the internal sealing surface to a second end. The bore is configured to receive a tube having a fluid channel so that an endface of the tube engages the internal sealing surface. The second end of the polymeric body is configured to contact a sealing surface of a coupling body that has a fluid channel extending from the sealing surface. A fluidic seal occurs when the coupling seal is compressed between the endface and the sealing surface. A void between an outer surface of the polymeric body and an inner surface of the coupling body receives the deformation of the coupling seal while under compression to thereby prevent the fluid channel of the tube from being crushed or obstructed.

A micro flow device for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The posts are spaced across the width of an expanded collection chamber region in the flow path, extending between the upper and lower surfaces thereof; they have rectilinear surfaces, being curved in cross-sections, e.g. circular or tear-drop shaped, and are randomly arranged so as to disrupt streamlined flow. The device is oriented so that its lower surface is aligned at about 45? to the horizontal. Sequestering agents, such as Abs, which are attached to surfaces of the collection region via a hydrophilic coating, preferably a permeable hydrogel containing isocyanate moieties, are highly effective in capturing cells or other targeted biomolecules while the remainder of the liquid sample exits horizontally.

A micro flow device (11, 71) for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts (23, 81). The posts are spaced across the width of an expanded collection chamber region (17, 75) in the flow path, extending between the upper and lower surfaces thereof; they have rectilinear surfaces, being curved in cross-sections, e.g. circular or tear-drop shaped, and are randomly arranged so as to disrupt streamlined flow. The device is oriented so that its lower surface is aligned at about 45? to the horizontal. Sequestering agents, such as Abs, which are attached to surfaces of the collection region via a hydrophilic coating, preferably a permeable hydrogel containing isocyanate moieties, are highly effective in capturing cells or other targeted biomolecules while the remainder of the liquid sample exits horizontally.

A dual containment fitting may include a primary tubing, a secondary tubing, and a dual containment body. The secondary tubing may surround and be concentric with a first portion of the primary tubing forming a first leak containment space between the primary tubing and the secondary tubing. The dual containment body may include a flare fitting portion and a primary containment nut portion. The flare fitting portion may surround and be concentric with the primary tubing forming a second leak containment space between the primary tubing and the flare fitting portion. The primary containment nut portion may surround and be concentric with the flared end of the primary tubing forming a third leak containment space between the primary tubing and the primary containment nut portion. The primary containment nut portion may include at least one leak passage hole connecting the third leak containment space with the second leak containment space.

A system includes a first body of a fluid-handling component and a second body of a fluid-handling component. The system also includes a fastener configured to couple the first body to the second body, and an annular sleeve configured to surround a portion of the fastener that is positioned at an interface between the first body and the second body when the first body and the second body are coupled to one another.

A fluidic coupling includes a compression screw having an axial bore, a threaded portion configured to engage a threaded bore of a coupling body, and a drive surface, a tube extending through the axial bore of the compression screw, the tube including a body and a fluidic channel extending through the body to a sealing end, the body including a pocket formed at the sealing end having a depth, a collet secured to an outer surface of the tube and having a first end configured to receive the drive surface of the compression screw, and a polymer seal having a channel to pass a fluid, the polymer seal including a flange portion and an insertion portion.

Provided herein is a pipe joint of a relatively small joint diameter for use under ultrahigh pressure conditions. The pipe joint includes first and second joint members having mutually communicating fluid passages; and a gasket interposed between abutting end surfaces of the first and second joint members. The first and second joint members have ring-shaped seal projections formed at the abutting end surfaces thereof. The pipe joint satisfies a coefficient F of 0.4 or less in the following formula (1).

F=(D.sub.3.sup.2D.sub.1.sup.2)/(D.sub.4.sup.2D.sub.2.sup.2), Formula (1):

where D.sub.1 represents the inner diameter of the first and second joint members, D.sub.2 represents the inner diameter of the gasket, D.sub.3 represents the diameter of the seal projections, and D.sub.4 represents the outer diameter of the gasket.

A pipe connection arrangement in a high-pressure fluid line system of a dual fuel engine, having first pipe element with outer sealing cone and conical shoulder adjoining the cone, having further pipe element with inner sealing cone and external thread, having a screw nut element with clamping sleeve region having inner clamping cone and threaded sleeve region having internal thread. The outer sealing cone of the first pipe element is arranged in the inner sealing cone of the further pipe element and the internal thread of the screw nut element is screwed on the external thread of the further pipe element. The inner clamping cone of the screw nut element is pulled against the conical shoulder of the first pipe element such that the outer and inner sealing cones are clamped with one another in a sealing manner, wherein the threaded sleeve region of the screw nut element is conical.