Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.

This document describes fluid coupling devices for fluid systems and methods of using the fluid coupling devices. Some fluid coupling devices described herein are configured for use in fluid systems for the purpose of providing a sterile connection. Such a sterile connection can be useful for the delivery and/or processing of therapeutic agents, or ingredients thereof, and other purposes.

This document describes fluid coupling devices for fluid systems and methods of using the fluid coupling devices. Some fluid coupling devices described herein are configured for use in fluid systems for the purpose of providing a sterile connection. Such a sterile connection can be useful for the delivery and/or processing of therapeutic agents, or ingredients thereof, and other purposes.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, disconnection functionality that can substantially limit fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, disconnection functionality that can substantially limit fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other.

This document describes fluid handling couplings. For example, this document describes fluid handling couplings that are genderless, that include manually openable valves, and that are configured for single-use aseptic fluid handling usage.

A device for the contamination-free filling of a tank from a canister is provided.

A device for the contamination-free filling of a tank from a canister is provided.

A coupling member for a blind mate fluid coupling includes a housing and a valve body that is self-centering and alignable relative to the housing. The valve body may include at least two radial shoulder portions or abutments that are configured to engage at least two corresponding radial abutments of the housing to improve self-centering when in a decoupled state. A biasing member may urge the valve body abutments against the corresponding housing abutments to compensate for misalignment and/or provide self-centering in both a decoupled and mated state.

A coupling member for a blind mate fluid coupling includes a housing and a valve body that is self-centering and alignable relative to the housing. The valve body may include at least two radial shoulder portions or abutments that are configured to engage at least two corresponding radial abutments of the housing to improve self-centering when in a decoupled state. A biasing member may urge the valve body abutments against the corresponding housing abutments to compensate for misalignment and/or provide self-centering in both a decoupled and mated state.