Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.

A clamp comprising: a first arcuate portion; a second arcuate portion hingedly connected to the first arcuate portion; and a ratchet mechanism for locking the first and second arcuate portions in a closed position; wherein the ratchet mechanism comprises a linear rack provided with the second arcuate portion and a pawl provided with the first arcuate portion for receiving the linear rack; wherein the linear rack comprises one or more asymmetrical teeth and the pawl comprises a finger which is configured to engage with the teeth of the linear rack. The pawl is formed by a module which is detachably connected to the first arcuate portion

An aseptic coupling device includes: a main body defining a front face; a membrane coupled to the front face, the membrane including a first portion coupled to the front face and a second portion folded over on the first portion; and a low friction member positioned between the first and second portions of the membrane.

Disclosed herein is a fluid connection port for forming a working fluid connection between a deformable, flexible tube and a fluid handling device, the fluid connection port comprising a bore extending from an exterior surface of the fluid handling device to an internal fluid handling feature, the bore comprising a narrow diameter bore section adjacent the exterior surface of the fluid handling device, a larger diameter bore section adjacent the internal fluid handling feature, and a shoulder separating the narrow diameter bore section and the larger diameter bore section, wherein the diameter of the bore at the narrow diameter bore section is less than the outside diameter of the deformable, flexible tube.

A flanged sealing ring which is used to seal a pipe connection is produced from a material having a metal fraction distributed substantially homogeneously in the flanged sealing ring. The flanged sealing ring can be used in a device for detecting components of a flanged sealing ring in a pipeline system that includes a plurality of pipes, at least two of which are held against each other at a flange in such a way that sealing is effected by a flanged sealing ring. Using a metal detector and a gate for removing a metal-containing substance from the pipeline, which gate is arranged behind the metal detector in the conveying direction, the flanged sealing ring can then be detected, and therefore, when components of the flanged sealing ring detach, detection can be performed at the metal detector and discharging can be performed at the gate.

Some fluid coupling devices described herein are configured for use in fluid systems. For example, some embodiments described in this document are single-use, aseptic fluid coupling devices that can be coupled to create a sterile flow path therethrough. Some such aseptic couplings are genderless couplings such that two identical aseptic couplings can be coupled together and then latched to form a robust connection between the aseptic couplings.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a sterile connection for drug delivery. In some embodiments, the fluid coupling devices can be implemented as multi-use, sterile fluid coupling devices that are configured to reduce the likelihood of fluid spillage when being disconnected.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, disconnection functionality that can substantially limit fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other.

An aseptic coupling arrangement can include a first coupling device and a second aseptic coupling device. In one embodiment, the first and second coupling devices are substantially similar, each having a main body defining a front face and a fluid passageway therethrough. A first connecting feature disposed on the main body of each coupling device may be provided for aligning and coupling the aseptic devices together. Each coupling device may also include a sealing member received in the main body and a membrane removably coupled to the main body front face to cover the sealing member. The first aseptic coupling device may also include a rotatable protective cover that is removably attached to the main body and connected to the membrane. In one embodiment, the removal of the protective covers away from two coupled main bodies, in a direction parallel to the front faces, causes removal of the membranes.

An adapter configured to allow interconnection of a device input connector (DIC) having a first connector configuration and an consumable end connector (CEC) having a second connector configuration, the adapter including a first end having a first connector mateable with the DIC, a second end configured to receive at least part of the CEC, a locking mechanism configured to lock the CEC to the adapter, and a release mechanism configured to release the CEC from the adapter.