A lyophilization promoting element to facilitate the transfer of heat between a lyophilizer and a pre-lyophilization solution. The element includes a base plate with a plurality of apertures. The base plate is made of a thermally conductive material and the apertures are regularly arranged within the base plate, each aperture being sized to receive a pharmaceutical vial container containing a pre-lyophilization solution. A method of lyophilizing includes inserting one or more pharmaceutical vial containers into the plurality of apertures of the lyophilization promoting element and placing the lyophilization promoting element holding the one or more pharmaceutical vial containers on a shelf of a lyophilizer.

An intelligent drying method and an ultraviolet sterilization container are applied to an ultraviolet sterilization container for drying a sterilized article, the method comprising: that the sterilization container sequentially executes the following steps after receiving a drying instruction: releasing hot air to an article storage cavity; when an initial drying time is reached, collecting the intracavity temperature of the article storage cavity; automatically obtaining an extended drying time corresponding to the intracavity temperature of the article storage cavity; and continuously releasing hot air to the article storage cavity until the extended drying time is reached. The ultraviolet sterilization container includes: an article storage cavity, a heating air duct, a microprocessor, and a memory storing a computer readable program executable by the microprocessor. When the computer readable program is executed by the microprocessor, the sterilization container performs the above steps.

Herein described are an assembly, apparatus and method for lyophilization that utilizes a thermal block made from a conductive material, the block having multiple wells designed and dimensioned to receive containers carrying material to be lyophilized in situ. In preferred embodiments, a vented silicone pad covers the wells and secures the containers therein, and a similarly vented rigid plate in turn secures the silicone pad by fastening it to the thermal block. The assembly can be turned up to 90 degrees resulting in the turning of the containers from an upright position to a horizontal position, a position in which the distance through which sublimation must progress is drastically reduced so as to greatly enhance the efficiency of the lyophilization process.

A dryer attachment for a vehicle, including: a coupler adapted to engage a heating, ventilation, and air conditioning (HVAC) duct of the vehicle; a flexible conduit coupled to the coupler; and a nozzle coupled to the flexible conduit opposite the coupler; wherein the coupler, the flexible conduit, and the nozzle are collectively adapted to deliver an air flow from the HVAC duct of the vehicle to an object disposed adjacent to a port of the nozzle. The coupler is adapted to engage a vent of the HVAC duct of the vehicle. Alternatively, the coupler is adapted to replace a vent of the HVAC duct of the vehicle. Alternatively, the coupler is adapted to engage a dedicated port of the HVAC duct of the vehicle.

An intelligent drying method and an ultraviolet sterilization container are applied to an ultraviolet sterilization container for drying a sterilized article, the method comprising: that the sterilization container sequentially executes the following steps after receiving a drying instruction: releasing hot air to an article storage cavity; when an initial drying time is reached, collecting the intracavity temperature of the article storage cavity; automatically obtaining an extended drying time corresponding to the intracavity temperature of the article storage cavity; and continuously releasing hot air to the article storage cavity until the extended drying time is reached. The ultraviolet sterilization container includes: an article storage cavity, a heating air duct, a microprocessor, and a memory storing a computer readable program executable by the microprocessor. When the computer readable program is executed by the microprocessor, the sterilization container performs the above steps.

A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest includes a base and first and second covers and is configured to support one or more receptacles each supporting one or more substances within interior spaces of the lyophilization nest. The interior spaces may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through the first and second covers. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior spaces when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.

A method for processing demineralized bone fibers, comprising a centrifuging step, and following the centrifuging step hydrated in sterile water to create a slurry; providing a tray to receive said fiber slurry; freezing the tray and fiber slurry; and lyophilizing the fiber slurry to create dried fibers.

A method of preparing a pharmaceutical product in a single multiple chamber flexible bag. A pharmaceutical product is introduced in a liquid state into a first chamber of the flexible bag through a first port. The pharmaceutical product is lyophilized within the first chamber of the flexible bag to provide a lyophilized pharmaceutical product. The flexible bag has a second chamber and the first chamber and the second chamber are separated by a breakable seal. The second chamber further includes a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber. A user may apply pressure to the flexible bag to break the seal and mix the lyophilized pharmaceutical product and the reconstituting solution to order to administer the pharmaceutical product to a patient.

Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.