A valve assembly used in a manifold system for processing fluid samples includes a body, a valve member, and a coupling assembly. The body defines a fluid passage and a valve passage in communication with the fluid passage and receiving at least a portion of the valve member therein. The valve member is selectively movable over a range of travel between an open position, in which fluid can flow through the fluid passage, and a closed position, in which the valve member occludes the fluid passage. The coupling assembly includes a coupling member and a retention lug. The retention lug is connected to one of the body and the coupling member. The other of the body and the coupling member defines a lug raceway configured to removably receive the retention lug therein to removably mount the coupling member to the body with the valve member being movably retained therebetween.

A valve arrangement includes a valve body having a stem rotatably attached at least partially within the body, a handle in operable communication with the stem and configured to rotate the stem by turning the handle, and an actuation portion in contact with the stem and configured to move when the handle is turned and the stem rotated. The actuation portion includes a carrier having an inner bore. The inner bore receives at least a portion of the stem. The stem includes first and second thread portions. The first thread portion has a first thread pitch at least partially received within the inner bore. The second thread portion is in communication with a bonnet attached to the body with a second thread pitch and moves the stem with respect to the body. The second pitch is smaller than the first pitch.

A method of controlling flow through a flexible tube includes providing a pinch clamp mechanism including a pinching element and a pinching surface configured to apply a force on the flexible tube when the flexible tube is positioned between the pinching element and the pinching surface. The method also includes displacing the pinching element relative to the pinching surface with a mechanical drive unit and biasing the pinching element toward the pinching surface with a spring.

A failsafe module comprising an input member (310), an output member (312), and a coupling mechanism for coupling the input member to the output member. The coupling mechanism comprises an intermediate member (316a) movable relative to the output member to energise an energy storage device and a latch mechanism (318, 320) to hold the energy storage device in an energised state. When the latch mechanism is engaged, the input and output members are coupled together and the energy storage device is held in an energised state and isolated from the coupling between the input and output members. When the latch mechanism is released, the energy storage device can release its energy to drive the output member to a predetermined position.

A valve cartridge may include an outer cylindrical body and an inner cylindrical body disposed in a channel formed by the outer cylindrical body. The outer cylindrical body may include a wall that defines the channel. The outer cylindrical body may include a ramped slot. The ramped slot may extend angularly from a first angular position on the wall to a second angular position. The ramped slot may extend longitudinally from a first longitudinal position on the wall to a second longitudinal position. The inner cylindrical body may include a handle interface approximate to a first end of the inner cylindrical body. The inner cylindrical body may include a pin extending radially from the inner cylindrical body and into the ramped slot. The inner cylindrical body may include a valve seat at a second end of the inner cylindrical body.

A valve cartridge may include an outer cylindrical body and an inner cylindrical body disposed in a channel formed by the outer cylindrical body. The outer cylindrical body may include a wall that defines the channel. The outer cylindrical body may include a ramped slot. The ramped slot may extend angularly from a first angular position on the wall to a second angular position. The ramped slot may extend longitudinally from a first longitudinal position on the wall to a second longitudinal position. The inner cylindrical body may include a handle interface approximate to a first end of the inner cylindrical body. The inner cylindrical body may include a pin extending radially from the inner cylindrical body and into the ramped slot. The inner cylindrical body may include a valve seat at a second end of the inner cylindrical body.

A valve actuation mechanism comprises a housing, an actuation pin rotatably mounted within the housing and at least one torque spring coupling the actuation pin to the housing for biasing the actuation pin from a first, inoperative rotational position towards a second, operative rotational position. The mechanism further comprises an actuation pin retaining element for selectively retaining the actuation pin in its first position, the retaining element being engageable with the actuation pin and the housing when the retaining element is in a retaining position so as to prevent rotation of the actuation pin towards its second position, and selectively disengageable from the housing to permit rotation of the actuation pin towards its second position. A locking element is provided for selectively preventing disengagement of the retaining element from the housing.

A valve actuation mechanism comprises a housing, an actuation pin rotatably mounted within the housing and at least one torque spring coupling the actuation pin to the housing for biasing the actuation pin from a first, inoperative rotational position towards a second, operative rotational position. The mechanism further comprises an actuation pin retaining element for selectively retaining the actuation pin in its first position, the retaining element being engageable with the actuation pin and the housing when the retaining element is in a retaining position so as to prevent rotation of the actuation pin towards its second position, and selectively disengageable from the housing to permit rotation of the actuation pin towards its second position. A locking element is provided for selectively preventing disengagement of the retaining element from the housing.

A rotational valve includes a valve closure element, a shaft, at least one detection element, at least one detection engagement means, at least one first stop and at least one second stop. The shaft is linked to the valve closure element and the shaft can rotate between a closed position and a fully open position. Each detection element comprises an aperture and an indicator element, the shaft extends through the aperture of at least one detection element, and each detection element is in sliding engagement with the shaft. The shaft can rotate relative to the detection element, each indicator element can move between a first and a second indicator position, each indicator element abuts a first stop when in the first indicator position and abuts a second stop when in the second indicator position.

A rotational valve includes a valve closure element, a shaft, at least one detection element, at least one detection engagement means, at least one first stop and at least one second stop. The shaft is linked to the valve closure element and the shaft can rotate between a closed position and a fully open position. Each detection element comprises an aperture and an indicator element, the shaft extends through the aperture of at least one detection element, and each detection element is in sliding engagement with the shaft. The shaft can rotate relative to the detection element, each indicator element can move between a first and a second indicator position, each indicator element abuts a first stop when in the first indicator position and abuts a second stop when in the second indicator position.