Manual and automated methods of pre-charging an empty or partially empty insulated container with CO2 snow are provided. A first location such as a charging location charges CO2 liquid into a container to create a pre-charged container with CO2 snow. The charging location prepares the pre-charged container for delivery to a second location, either by itself, or through a third party. The second location may be a clinical site, which upon receipt of the pre-charged container, loads a perishable item such as a biological sample into the pre-charged container. A user receives the pre-charged container with perishable item and removes the perishable item from the pre-charger container for testing (e.g., biological testing). Depending on the level of depletion of the CO2 snow in the pre-charged container, the user returns the depleted container to the first location or the intermediate location.

Insulation container for the temperature-controlled transport of pharmaceutical products, comprising an outer container with an outer container base and an outer container wall, which are connected to one another in such a way as to form a receiving space open on one side, and wherein the insulation container comprises a lid which is designed to completely cover the receiving space by placing the lid on the outer container, and wherein the insulation container furthermore has a receiving space comprises inserted compartment which separates the receiving space into separate compartments.

A medical contact shock freezer (10) adapted for fast freezing a plurality of individual bags (41-43, 51-53) containing a medical liquid, the individual bags being arranged side by side, adjacent to each other, in which the contact shock freezer comprises a pair of freezing plates comprising an upper freezing plate (21) and a lower freezing plate (22), at least one of the upper and lower freezing plates of the pair being moveable to define i) a loading position in which sufficient separation is provided between the freezing plates to load or unload the individual bags between the freezing plates and ii) a freezing position in which each individual bag is in contact with and is clamped between a contact surface of the upper freezing plate and a contact surface of the lower freezing plate; and in which, in its freezing position, the contact surface of the upper freezing plate is arranged at an angle of at least 2° to the horizontal.

A flexible pouch is placed in a stack provided with two plates forming a protecting body to sandwich and constrain the flexible pouch. At opposite margin portions, the protecting body has slots cooperating with positioning members of an outer shell device belonging to the stack. Between the shell parts, the plates can move during filling of the pouch and the margin portions shrink inwardly in a protecting body plane. Some of the positioning members act as stoppers, in order to have lower clearance range for shrink strokes of the protecting body in a middle part thereof, as compared to a higher clearance range at respective longitudinal end parts of the two opposite margin portions. A higher constraining effect can be obtained in a center of the pouch, to limit maximum thickness of its content, which is of interest for managing freeze/thaw operations of biopharmaceutical materials contained in the pouch.

The invention relates to a cryogenic container for storing and/or transporting a medium, in particular a biochemical and/or medical product. The cryogenic container comprises at least one primary container, which has at least one flexible film bag. The flexible film bag is designed to receive the medium. The cryogenic container furthermore comprises at least one secondary container, which at least partially surrounds the primary container and is preferably at least partially flexible. The secondary container has at least one opening for insertion of the primary container. The secondary container furthermore has at least one preferably at least partially flexible outer sleeve. The secondary container furthermore has at least one heat exchanger space, which is arranged between the outer sleeve and the flexible film bag and receives at least one fluid heat exchange medium.

A portable insulated medicament container is provided herein. The container comprising a housing defining a cavity for receiving medicament for maintaining temperature control of the medicament, the housing comprising an opening for accessing the cavity, and the housing further comprising one or more cooling elements disposed therein. A method for using a portable insulated medicament container is also provided herein. The method includes placing the medicament into the container without the need for a container warming period.

A portable cooling unit for cooling and insulating a vessel. The unit has a thermally insulating envelope that includes a breathable reflective layer, a breathable waterproof layer and an opening for accessing the vessel. A cooling envelope that is arranged to cool and house the thermally insulating envelope and the vessel. The cooling envelope has two water-permeable layers and an opening for accessing the vessel. The unit further has a housing envelope that is arranged to house the vessel, the cooling envelope and the thermally insulating envelope. The housing envelope includes an opening for accessing the vessel and a breathable water-permeable layer that allows moisture to cross the envelope. The two water-permeable layers of the cooling layer are arranged to bound an enclosure containing an absorbent and moisture-wicking material that is arranged to cool the vessel via evaporation of water.

Disclosed is a device for cooling a body or body part for medical or performance-enhancing purposes, said device consisting of one or more cooling elements (11), said cooling element (11) being provided with a cover (1) that is filled with meltable cooling solid (2). The disclosed device is characterized in that an additional apparatus for displacing the already melted portion (8) of the cooling solid (2) from the contact surface (7) to the body is provided inside the cover (1), the expandable member (4, 6) being preferably designed in the form of a filled member (4) of a spring element (6) or of a foamed article. Also disclosed is an additional device which is characterized in that a layer (16) of thermochromic material indicates when a threshold temperature is exceeded, said layer (16) being applied to the bottom side of the expandable member and thus being pressed against the remaining solid portion of the cooling solid, the cover (1) being transparent in this case.

Provided is a compact lightweight transport box in which the internal temperature distribution is minimized and accurate temperature regulation can be performed. The transport box includes an insulating container, an internal heat conducting container mounted in the insulating container, and an insulating cover body with a cover internal side heat conducting plate exposed on an inner surface facing the opening part of the internal heat conducting container, in which, with the opening part of the insulating container closed by the insulating cover body, the cover internal side heat conducting plate is near an opening end of the internal heat conducting container.

A refrigeration device includes a thermal transfer unit with an evaporative region, an adiabatic region, and a condensing region with a reversible valve attached to the adiabatic region. The device includes a container sealed around PCM, with a set of refrigeration coils of a compressor unit in thermal contact with the PCM. A storage region is in thermal contact with the evaporative region of the thermal transfer unit. A controller is operably connected to the reversible valve and the refrigeration compressor unit. The storage region can be used to store cold packs within a predetermined temperature range for medical outreach.