Hydrogen liquification includes three streams of refrigerant at between 320 to 425 degrees F. A fourth stream has ambient temperature and pressure between 150 to 650 PSIA. Fourth stream cooling flows are cooled by heat exchangers to between 320 to 270 degrees F. A first flow of these cooling flows is reduced across a valve to a two-phase mixture directed to fourth warming flows. A separate fifth stream has ambient temperature and pressure of between 700 and 1200 PSIA. Fifth stream cooling flows have a first flow portion removed by a splitter at between 0 and 60 degrees F., and a second flow portion removed at between 160 and 100 degrees F. The first flow portion and a cooled flow of the second flow portion are feed into expanders that power fifth compressors to reduce a temperature of the fifth stream to serve as the first and second flow portions.

A LNG liquefaction plant system includes concurrent power production, wherein the refrigeration content of the refrigerant or SMR is used to liquefy and sub-cool a natural gas stream in a cold box or cryogenic exchanger. For concurrent power production, the system uses waste heat from refrigerant compression to vaporize and superheat a waste heat working fluid that in turn drives a compressor for refrigerant compression. The refrigerant may be an external SMR or an internal LNG refrigerant working fluid expanded and compressed by a twin compander arrangement.

The disclosure provides a method and system for optimizing production of a natural gas liquefaction process, the method comprising the steps of: selecting at least one manipulated variable (MV) for controlling the liquefaction process; selecting at least one control variable (CV), the at least one control variable at least comprising liquefied natural gas (LNG) throughput; providing at least one model, each model providing a dependency of the at least one control variable (CV) on the at least one manipulated variable (MV); using the at least one model to estimate LNG throughput for at least one of the manipulated variables (MV); obtaining process data from the liquefaction process, the process data at least including observed values of LNG throughput; creating a gain matrix based on said interdependencies; and using the gain matrix to optimize a process control system of the liquefaction process.

Described herein are methods and systems for liquefying natural gas by: cooling and liquefying a natural gas feed stream via indirect heat exchange with at least a first cold refrigerant stream to form a first liquefied natural gas stream and a warmed gaseous refrigerant stream; flashing and separating the first liquefied natural gas stream to form a liquefied natural gas product stream and at least a first flash gas stream; combining and compressing the first flash gas stream and the warmed gaseous refrigerant stream to form a compressed refrigerant stream; and expanding at least a first portion of the compressed refrigerant stream to form the first cold refrigerant stream; wherein the natural gas feed stream is kept separate from and is not combined with either the first flash gas stream or the compressed refrigerant stream.

Herein pipeline pressure, temperature and NGL constituents are manipulated for the transportation and optional storage in a pipeline system of natural gas mixtures or rich mixtures for delivery of chilled Products for downstream applications. Pressure reduction from a last compression section delivers internally chilled Products for reduced capital and operating costs. A high lift compressor station before the pipeline terminus provides pressure differential for Joule-Thompson chilling of the pipeline contents. The chilling step can be retrofitted to existing pipeline systems, and the chilling steep can include a turbo expander or the like for recovery of pipeline pressure energy for power generation. For like throughout, with this higher pressure operation, the effects of enhanced NGL content results in a reduction in diameter of the pipeline by at least one standard size. Substantial overall reduction in energy consumption and associated CO2 emissions is thereby achieved through integrated pipeline/processing applications.

Methods and systems for liquefying natural gas by: cooling and liquefying a natural gas feed stream via indirect heat exchange with at least a first cold refrigerant stream to form a first liquefied natural gas stream and a warmed gaseous refrigerant stream; flashing and separating the first liquefied natural gas stream to form a liquefied natural gas product stream and at least a first flash gas stream; combining and compressing the first flash gas stream and the warmed gaseous refrigerant stream to form a compressed refrigerant stream; and expanding at least a first portion of the compressed refrigerant stream to form the first cold refrigerant stream; wherein the natural gas feed stream is kept separate from and is not combined with either the first flash gas stream or the compressed refrigerant stream.

Techniques for generating a personalized reference sequence construct for an individual to align sequence reads obtained for the individual. The techniques include: obtaining a plurality of sequence reads for an individual; obtaining information identifying a plurality of locations; genotyping the plurality of sequence reads for the plurality of locations to obtain a first set of variants for the individual for at least some of the plurality of locations; identifying a second set of variants associated with the first set of variants; generating a personalized reference sequence construct using the second set of variants; and aligning the plurality of sequence reads to the personalized reference sequence construct.