A spray drying process and apparatus for drying a spray dryable liquid composition to a spray dried powder is described, in which the spray dryable liquid composition contains no carrier. The spray dryable liquid composition is processed at a solids concentration not exceeding 80% by weight, based on total weight of the spray dryable liquid composition, being atomized to generate an atomized spray of liquid particles of the spray dryable liquid composition into a spray drying chamber, in which the atomized spray is contacted with a stream of drying fluid flowed at temperature not exceeding 100 C. into the spray drying chamber, to form the spray dried powder.

A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated. The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.

A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated. The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.

Spray drying method and systems are disclosed that include one or more single-use components. Single-use spray drying systems can include a drying chamber with an inner surface formed of a polymeric material. The single-use components can be pre-sterilized and sterile packaged to provide improved efficiencies and greater flexibility in spray drying systems.

Spray drying method and systems are disclosed that include one or more single-use components. Single-use spray drying systems can include a drying chamber with an inner surface formed of a polymeric material. The single-use components can be pre-sterilized and sterile packaged to provide improved efficiencies and greater flexibility in spray drying systems.

An electrostatic sprayer operable at high flow rates and low pressures particularly suitable for spray drying. The sprayer includes an elongated body having a downstream spray nozzle assembly through which electrically charged liquid is directed via a central feed tube within the nozzle body and atomizing air is supplied via an annular passage about the liquid feed tube. In one embodiment, the nozzle assembly is an external mix cluster head spray nozzle assembly having a plurality of circumferentially spaced metallic spray tips. In another embodiment, the spray nozzle is an internal mix nozzle assembly having a spray tip with an internal mixing chamber for atomizing liquid prior to discharge.

The present invention provides for a process for producing dry, water-dispersible, non-surface modified nanocellulose particles or a powderous composition r comprising said particles comprising the steps of: i. providing a first suspension of non-surface modified cellulose particles in an first aqueous liquid, which aqueous liquid is non-solubilizing for the non-surface modified nanocellulose particles, ii. exchanging substantially all of the first aqueous liquid of the first suspension for a second solvent, which is miscible with the first aqueous liquid and non-solubilizing for the non-surface modified nanocellulose particles, to form a second suspension of non-surface modified nanocellulose particles in said second solvent, iii. contacting a flow of the second suspension of non-surface modified nanocellulose particles with a flow of a fluid in a supercritical or critical state, which fluid in a supercritical or critical state is miscible with the second solvent and non-solvating for the non-surface modified nanocellulose particles under conditions suitable for the transfer of substantially all of the second solvent into the supercritical fluid, iv. removing the second solvent and the fluid in a supercritical or critical state, preferably by controlling pressure and/or temperature, to form the dry, water-dispersible nanocellulose particles, v. collecting the dry, water-dispersible, non-surface modified nanocellulose particles and/or forming the powderous composition comprising said particles.

The present invention provides for a process for producing dry, water-dispersible, non-surface modified nanocellulose particles or a powderous composition r comprising said particles comprising the steps of: i. providing a first suspension of non-surface modified cellulose particles in an first aqueous liquid, which aqueous liquid is non-solubilizing for the non-surface modified nanocellulose particles, ii. exchanging substantially all of the first aqueous liquid of the first suspension for a second solvent, which is miscible with the first aqueous liquid and non-solubilizing for the non-surface modified nanocellulose particles, to form a second suspension of non-surface modified nanocellulose particles in said second solvent, iii. contacting a flow of the second suspension of non-surface modified nanocellulose particles with a flow of a fluid in a supercritical or critical state, which fluid in a supercritical or critical state is miscible with the second solvent and non-solvating for the non-surface modified nanocellulose particles under conditions suitable for the transfer of substantially all of the second solvent into the supercritical fluid, iv. removing the second solvent and the fluid in a supercritical or critical state, preferably by controlling pressure and/or temperature, to form the dry, water-dispersible nanocellulose particles, v. collecting the dry, water-dispersible, non-surface modified nanocellulose particles and/or forming the powderous composition comprising said particles.

A crystallization apparatus for a crystallization of a preliminary product. The crystallization apparatus includes an inlet for receiving the preliminary product, a rotary drive, and a rotatable receiving unit having, on an upper side thereof, a circular surface and/or an annular surface for the crystallization so that, when the rotatable receiving unit is rotated, the preliminary product received can be recrystallized in a defined manner on the circular surface and/or the annular surface and can be discharged as a crystallized product.

The invention concerns a powder drying system (1) comprising a carbon monoxide (CO) gas detection system adapted for detection of CO gas from smoldering powders in a powder drying system component, such as a spray dryer chamber (200), a fluid bed (500) or a bag filter (400), which CO gas detection system comprises at least one inlet CO gas detector (3) arranged on at least one gas inlet of a powder drying system component such as to provide at least one inlet CO gas content measurement, at least one outlet CO gas detector (3) arranged on at least one gas outlet of a powder drying system component such as to provide at least one outlet CO gas content measurement, and an analyzing unit (5) adapted for receiving the at least one inlet CO gas content measurement, receiving the at least one outlet CO gas content measurement and comparing the sum of the at least one inlet CO gas content measurement and the sum of the at least one outlet CO gas content measurement while compensating for dilution, mixing, and time delay of the outlet CO gas content measurement. At least the at least one outlet CO gas detector (3) comprises an IR laser transmitter and is adapted for detecting over a measurement volume (6) and is arranged on the at least one gas outlet in such a way that said measurement volume (6) extends directly inside a gas flow (20) in said at least one gas outlet.